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Volumn 11, Issue 1, 2011, Pages 59-67

RNA interference in the clinic: Challenges and future directions

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; MACROGOL; NANOPARTICLE; RNA; SMALL INTERFERING RNA;

EID: 78650624101     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2966     Document Type: Review
Times cited : (718)

References (99)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
    • DOI 10.1038/35888
    • Fire, A. et al. Potent and specific genetic interference by double-strandedRNA in Caenorhabditis elegans. Nature 391, 806-811 (1998). (Pubitemid 28099681)
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 2
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker, B. J. et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N. Engl. J. Med. 355, 2408-2417 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 2408-2417
    • Druker, B.J.1
  • 3
    • 33845914783 scopus 로고    scopus 로고
    • 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: A randomised controlled trial
    • Smith, I. et al. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 369, 29-36 (2007).
    • (2007) Lancet , vol.369 , pp. 29-36
    • Smith, I.1
  • 4
    • 27944467785 scopus 로고    scopus 로고
    • New-clear functions of PDK1: Beyond a master kinase in the cytosol?
    • Kikani, C. K., Dong, L. Q. & Liu, F. "New"-clear functions of PDK1: beyond a master kinase in the cytosol? J. Cell. Biochem. 96, 1157-1162 (2005).
    • (2005) J. Cell. Biochem. , vol.96 , pp. 1157-1162
    • Kikani, C.K.1    Dong, L.Q.2    Liu, F.3
  • 5
    • 48849089827 scopus 로고    scopus 로고
    • FERM control of FAK function: Implications for cancer therapy
    • Lim, S. T., Mikolon, D., Stupack, D. G. & Schlaepfer, D. D. FERM control of FAK function: implications for cancer therapy. Cell Cycle 7, 2306-2314 (2008).
    • (2008) Cell Cycle , vol.7 , pp. 2306-2314
    • Lim, S.T.1    Mikolon, D.2    Stupack, D.G.3    Schlaepfer, D.D.4
  • 6
    • 42949176742 scopus 로고    scopus 로고
    • Survival of cancer cells is maintained by EGFR independent of its kinase activity
    • Weihua, Z. et al. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell 13, 385-393 (2008).
    • (2008) Cancer Cell , vol.13 , pp. 385-393
    • Weihua, Z.1
  • 7
    • 77951132901 scopus 로고    scopus 로고
    • Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
    • Davis, M. E. et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 464, 1067-1070 (2010). This is the first report of using targeted nanoparticles for siRNA delivery in humans.
    • (2010) Nature , vol.464 , pp. 1067-1070
    • Davis, M.E.1
  • 9
    • 33845755467 scopus 로고    scopus 로고
    • Illuminating the silence: Understanding the structure and function of small RNAs
    • Rana, T. M. Illuminating the silence: understanding the structure and function of small RNAs. Nature Rev. Mol. Cell Biol. 8, 23-36 (2007).
    • (2007) Nature Rev. Mol. Cell Biol. , vol.8 , pp. 23-36
    • Rana, T.M.1
  • 10
    • 70349461193 scopus 로고    scopus 로고
    • Regulating the regulators: Posttranslational modifications of RNA silencing factors
    • Heo, I. & Kim, V. N. Regulating the regulators: posttranslational modifications of RNA silencing factors. Cell 139, 28-31 (2009).
    • (2009) Cell , vol.139 , pp. 28-31
    • Heo, I.1    Kim, V.N.2
  • 11
    • 4644350944 scopus 로고    scopus 로고
    • Unlocking the potential of the human genome with RNA interference
    • Hannon, G. J. & Rossi, J. J. Unlocking the potential of the human genome with RNA interference. Nature 431, 371-378 (2004).
    • (2004) Nature , vol.431 , pp. 371-378
    • Hannon, G.J.1    Rossi, J.J.2
  • 12
    • 4644223259 scopus 로고    scopus 로고
    • Mechanisms of gene silencing by double-stranded RNA
    • Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. Nature 431, 343-349 (2004).
    • (2004) Nature , vol.431 , pp. 343-349
    • Meister, G.1    Tuschl, T.2
  • 13
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • Martinez, J., Patkaniowska, A., Urlaub, H., Lührmann, R. & Tuschl, T. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 110, 565-574 (2002).
    • (2002) Cell , vol.110 , pp. 565-574
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Lührmann, R.4    Tuschl, T.5
  • 14
    • 4444368187 scopus 로고    scopus 로고
    • Argonaute2 is the catalytic engine of mammalian RNAi
    • Liu, J. et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science 305, 1437-1441 (2004).
    • (2004) Science , vol.305 , pp. 1437-1441
    • Liu, J.1
  • 15
    • 3242736704 scopus 로고    scopus 로고
    • Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
    • Meister, G. et al. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol. Cell 15, 185-197 (2004).
    • (2004) Mol. Cell , vol.15 , pp. 185-197
    • Meister, G.1
  • 16
    • 18344369543 scopus 로고    scopus 로고
    • MicroRNA biogenesis: Coordinated cropping and dicing
    • Kim, V. N. MicroRNA biogenesis: coordinated cropping and dicing. Nature Rev. Mol. Cell Biol. 6, 376-385 (2005).
    • (2005) Nature Rev. Mol. Cell Biol. , vol.6 , pp. 376-385
    • Kim, V.N.1
  • 17
    • 1642499415 scopus 로고    scopus 로고
    • Exportin-5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs
    • Bohnsack, M. T., Czaplinski, K. & Gorlich, D. Exportin-5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 10, 185-191 (2004).
    • (2004) RNA , vol.10 , pp. 185-191
    • Bohnsack, M.T.1    Czaplinski, K.2    Gorlich, D.3
  • 18
    • 33745894330 scopus 로고    scopus 로고
    • Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54
    • Chu, C. & Rana, T. M. Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PLoS Biol. 4, e210 (2006).
    • (2006) PLoS Biol. , vol.4
    • Chu, C.1    Rana, T.M.2
  • 19
    • 77954065909 scopus 로고    scopus 로고
    • Beyond genomics: Interpreting the 93% of the human genome that does not encode proteins
    • Fabbri, M. & Calin, G. A. Beyond genomics: interpreting the 93% of the human genome that does not encode proteins. Curr. Opin. Drug Discov. Devel. 13, 350-358.
    • Curr. Opin. Drug Discov. Devel. , vol.13 , pp. 350-358
    • Fabbri, M.1    Calin, G.A.2
  • 20
  • 21
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • Soutschek, J. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432, 173-178 (2004).
    • (2004) Nature , vol.432 , pp. 173-178
    • Soutschek, J.1
  • 22
    • 0038606999 scopus 로고    scopus 로고
    • Structural variations and stabilizing modifications of synthetic siRNAs in mammalian cells
    • Czauderna, F. et al. Structural variations and stabilizing modifications of synthetic siRNAs in mammalian cells. Nucleic Acids Res. 31, 2705-2716 (2003).
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2705-2716
    • Czauderna, F.1
  • 23
    • 33847036990 scopus 로고    scopus 로고
    • Strategies for silencing human disease using RNA interference
    • Kim, D. H. & Rossi, J. J. Strategies for silencing human disease using RNA interference. Nature Rev. Genet. 8, 173-184 (2007).
    • (2007) Nature Rev. Genet. , vol.8 , pp. 173-184
    • Kim, D.H.1    Rossi, J.J.2
  • 24
    • 51049108389 scopus 로고    scopus 로고
    • Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution
    • Dobrovolskaia, M. A., Aggarwal, P., Hall, J. B. & McNeil, S. E. Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. Mol. Pharm. 5, 487-495 (2008).
    • (2008) Mol. Pharm. , vol.5 , pp. 487-495
    • Dobrovolskaia, M.A.1    Aggarwal, P.2    Hall, J.B.3    McNeil, S.E.4
  • 25
    • 0025255160 scopus 로고
    • Microvascular architecture of experimental colon tumors in the rat
    • Skinner, S. A., Tutton, P. J. & O'Brien, P. E. Microvascular architecture of experimental colon tumors in the rat. Cancer Res. 50, 2411-2417 (1990).
    • (1990) Cancer Res. , vol.50 , pp. 2411-2417
    • Skinner, S.A.1    Tutton, P.J.2    O'Brien, P.E.3
  • 26
    • 33645985153 scopus 로고    scopus 로고
    • The effective dispersion of nanovectors within the tumor microvasculature
    • Decuzzi, P., Causa, F., Ferrari, M. & Netti, P. A. The effective dispersion of nanovectors within the tumor microvasculature. Ann. Biomed. Eng. 34, 633-641 (2006).
    • (2006) Ann. Biomed. Eng. , vol.34 , pp. 633-641
    • Decuzzi, P.1    Causa, F.2    Ferrari, M.3    Netti, P.A.4
  • 27
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong, R. T. et al. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 64, 3731-3736 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 3731-3736
    • Tong, R.T.1
  • 28
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura, Y. & Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46, 6387-6392 (1986).
    • (1986) Cancer Res. , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 29
    • 77952575335 scopus 로고    scopus 로고
    • Tumor-selective delivery of macromolecular drugs via the EPR effect: Background and future prospects
    • Maeda, H. Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects. Bioconjug. Chem. 21, 797-802 (2010).
    • (2010) Bioconjug. Chem. , vol.21 , pp. 797-802
    • Maeda, H.1
  • 30
    • 43849112187 scopus 로고    scopus 로고
    • The receptor-mediated endocytosis of nonspherical particles
    • Decuzzi, P. & Ferrari, M. The receptor-mediated endocytosis of nonspherical particles. Biophys. J. 94, 3790-3797 (2008).
    • (2008) Biophys. J. , vol.94 , pp. 3790-3797
    • Decuzzi, P.1    Ferrari, M.2
  • 31
    • 77951168054 scopus 로고    scopus 로고
    • Breaking down the barriers: SiRNA delivery and endosome escape
    • Dominska, M. & Dykxhoorn, D. M. Breaking down the barriers: siRNA delivery and endosome escape. J. Cell Sci. 123, 1183-1189 (2010).
    • (2010) J. Cell Sci. , vol.123 , pp. 1183-1189
    • Dominska, M.1    Dykxhoorn, D.M.2
  • 32
    • 34547095748 scopus 로고    scopus 로고
    • Pancreatic cancer microenvironment
    • Kleeff, J. et al. Pancreatic cancer microenvironment. Int. J. Cancer 121, 699-705 (2007).
    • (2007) Int. J. Cancer , vol.121 , pp. 699-705
    • Kleeff, J.1
  • 33
    • 41149086686 scopus 로고    scopus 로고
    • Extracellular barriers to in Vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver
    • Burke, R. S. & Pun, S. H. Extracellular barriers to in Vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver. Bioconjug. Chem. 19, 693-704 (2008).
    • (2008) Bioconjug. Chem. , vol.19 , pp. 693-704
    • Burke, R.S.1    Pun, S.H.2
  • 34
    • 55249103122 scopus 로고    scopus 로고
    • 3-D tissue culture systems for the evaluation and optimization of nanoparticle-based drug carriers
    • Goodman, T. T., Ng, C. P. & Pun, S. H. 3-D tissue culture systems for the evaluation and optimization of nanoparticle-based drug carriers. Bioconjug. Chem. 19, 1951-1959 (2008).
    • (2008) Bioconjug. Chem. , vol.19 , pp. 1951-1959
    • Goodman, T.T.1    Ng, C.P.2    Pun, S.H.3
  • 35
    • 1542287347 scopus 로고    scopus 로고
    • Neutrophil extracellular traps kill bacteria
    • Brinkmann, V. et al. Neutrophil extracellular traps kill bacteria. Science 303, 1477-1478 (2004).
    • (2004) Science , vol.303 , pp. 1477-1478
    • Brinkmann, V.1
  • 36
    • 74849119169 scopus 로고    scopus 로고
    • Phagocytosis independent extracellular nanoparticle clearance by human immune cells
    • Bartneck, M., Keul, H. A., Zwadlo-Klarwasser, G. & Groll, J. Phagocytosis independent extracellular nanoparticle clearance by human immune cells. Nano Lett. 10, 59-63 (2010).
    • (2010) Nano Lett. , vol.10 , pp. 59-63
    • Bartneck, M.1    Keul, H.A.2    Zwadlo-Klarwasser, G.3    Groll, J.4
  • 37
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge, A. D. et al. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nature Biotech. 23, 457-462 (2005).
    • (2005) Nature Biotech. , vol.23 , pp. 457-462
    • Judge, A.D.1
  • 38
    • 44649137559 scopus 로고    scopus 로고
    • Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses
    • Forsbach, A. et al. Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses. J. Immunol. 180, 3729-3738 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 3729-3738
    • Forsbach, A.1
  • 39
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
    • Jackson, A. L. & Linsley, P. S. Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nature Rev. Drug Discov. 9, 57-67 (2010).
    • (2010) Nature Rev. Drug Discov. , vol.9 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 41
    • 41649115210 scopus 로고    scopus 로고
    • Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
    • Kleinman, M. E. et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 452, 591-597 (2008).
    • (2008) Nature , vol.452 , pp. 591-597
    • Kleinman, M.E.1
  • 42
    • 3242813113 scopus 로고    scopus 로고
    • The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    • Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nature Immunol. 5, 730-737 (2004).
    • (2004) Nature Immunol. , vol.5 , pp. 730-737
    • Yoneyama, M.1
  • 43
    • 77953686812 scopus 로고    scopus 로고
    • Enabling individualized therapy through nanotechnology
    • Sakamoto, J. H. et al. Enabling individualized therapy through nanotechnology. Pharmacol. Res. 1-31 (2010).
    • (2010) Pharmacol. Res. , pp. 1-31
    • Sakamoto, J.H.1
  • 44
    • 16244362066 scopus 로고    scopus 로고
    • Cationic lipids enhance siRNA-mediated interferon response in mice
    • Ma, Z. et al. Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem. Biophys. Res. Commun. 330, 755-759 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.330 , pp. 755-759
    • Ma, Z.1
  • 45
    • 24644504130 scopus 로고    scopus 로고
    • Toxicogenomics of cationic lipid-based vectors for gene therapy: Impact of microarray technology
    • Omidi, Y., Barar, J. & Akhtar, S. Toxicogenomics of cationic lipid-based vectors for gene therapy: impact of microarray technology. Curr. Drug Deliv. 2, 429-441 (2005).
    • (2005) Curr. Drug Deliv. , vol.2 , pp. 429-441
    • Omidi, Y.1    Barar, J.2    Akhtar, S.3
  • 46
    • 0034096243 scopus 로고    scopus 로고
    • Oxygen radical-mediated pulmonary toxicity induced by some cationic liposomes
    • Dokka, S., Toledo, D., Shi, X., Castranova, V. & Rojanasakul, Y. Oxygen radical-mediated pulmonary toxicity induced by some cationic liposomes. Pharm. Res. 17, 521-525 (2000).
    • (2000) Pharm. Res. , vol.17 , pp. 521-525
    • Dokka, S.1    Toledo, D.2    Shi, X.3    Castranova, V.4    Rojanasakul, Y.5
  • 47
    • 0242719919 scopus 로고    scopus 로고
    • Cellular pharmacology of P-ethoxy antisense oligonucleotides targeted to Bcl-2 in a follicular lymphoma cell line
    • Gutierrez-Puente, Y. et al. Cellular pharmacology of P-ethoxy antisense oligonucleotides targeted to Bcl-2 in a follicular lymphoma cell line. Leuk. Lymphoma 44, 1979-1985 (2003).
    • (2003) Leuk. Lymphoma , vol.44 , pp. 1979-1985
    • Gutierrez-Puente, Y.1
  • 48
    • 23044506285 scopus 로고    scopus 로고
    • Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery
    • Landen, C. N. et al. Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. Cancer Res. 65, 6910-6918 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 6910-6918
    • Landen, C.N.1
  • 49
    • 77955530763 scopus 로고    scopus 로고
    • SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer
    • Ahmed, A. A. et al. SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer. Cancer Cell 18, 109-121 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 109-121
    • Ahmed, A.A.1
  • 51
    • 46549085779 scopus 로고    scopus 로고
    • Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer
    • Kim, S. H., Jeong, J. H., Lee, S. H., Kim, S. W. & Park, T. G. Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. J. Control. Release 129, 107-116 (2008).
    • (2008) J. Control. Release , vol.129 , pp. 107-116
    • Kim, S.H.1    Jeong, J.H.2    Lee, S.H.3    Kim, S.W.4    Park, T.G.5
  • 52
    • 35148815670 scopus 로고    scopus 로고
    • Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
    • Wolfrum, C. et al. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nature Biotech. 25, 1149-1157 (2007).
    • (2007) Nature Biotech. , vol.25 , pp. 1149-1157
    • Wolfrum, C.1
  • 53
    • 43049176170 scopus 로고    scopus 로고
    • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
    • Akinc, A. et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nature Biotech. 26, 561-569 (2008).
    • (2008) Nature Biotech. , vol.26 , pp. 561-569
    • Akinc, A.1
  • 54
    • 76649098887 scopus 로고    scopus 로고
    • Lipid-like materials for low-dose, in vivo gene silencing
    • Love, K. T. et al. Lipid-like materials for low-dose, in vivo gene silencing. Proc. Natl Acad. Sci. USA 107, 1864-1869 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 1864-1869
    • Love, K.T.1
  • 55
    • 33751404700 scopus 로고    scopus 로고
    • Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity
    • Hunter, A. C. Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity. Adv. Drug Deliv. Rev. 58, 1523-1531 (2006).
    • (2006) Adv. Drug Deliv. Rev. , vol.58 , pp. 1523-1531
    • Hunter, A.C.1
  • 56
    • 77953702051 scopus 로고    scopus 로고
    • Dendrimer toxicity: Let's meet the challenge
    • Jain, K., Kesharwani, P., Gupta, U. & Jain, N. K. Dendrimer toxicity: let's meet the challenge. Int. J. Pharm. 394, 122-142 (2010).
    • (2010) Int. J. Pharm. , vol.394 , pp. 122-142
    • Jain, K.1    Kesharwani, P.2    Gupta, U.3    Jain, N.K.4
  • 57
    • 33846169452 scopus 로고    scopus 로고
    • Intravenous delivery of anti-RhoA small interfering RNA Loaded in nanoparticles of chitosan in mice: Safety and efficacy in xenografted aggressive breast cancer
    • Pille, J. Y. et al. Intravenous delivery of anti-RhoA small interfering RNA Loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer. Hum. Gene Ther. 17, 1019-1026 (2006).
    • (2006) Hum. Gene Ther. , vol.17 , pp. 1019-1026
    • Pille, J.Y.1
  • 58
    • 77955113615 scopus 로고    scopus 로고
    • Targeted gene silencing using RGD-labeled chitosan nanoparticles
    • Han, H. D. et al. Targeted gene silencing using RGD-labeled chitosan nanoparticles. Clin. Cancer Res. 16, 3910-3922 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3910-3922
    • Han, H.D.1
  • 59
    • 77955541508 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by EZH2
    • Lu, C. et al. Regulation of tumor angiogenesis by EZH2. Cancer Cell 18, 185-197 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 185-197
    • Lu, C.1
  • 60
    • 34347272315 scopus 로고    scopus 로고
    • Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA
    • Heidel, J. D. et al. Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA. Proc. Natl Acad. Sci. USA 104, 5715-5721 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 5715-5721
    • Heidel, J.D.1
  • 61
    • 24744464786 scopus 로고    scopus 로고
    • Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo
    • Takeshita, F. et al. Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. Proc. Natl Acad. Sci. USA 102, 12177-12182 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 12177-12182
    • Takeshita, F.1
  • 62
    • 0037685280 scopus 로고    scopus 로고
    • Expression profiling reveals off-target gene regulation by RNAi
    • Jackson, A. L. et al. Expression profiling reveals off-target gene regulation by RNAi. Nature Biotech. 21, 635-637 (2003).
    • (2003) Nature Biotech. , vol.21 , pp. 635-637
    • Jackson, A.L.1
  • 63
    • 33745612464 scopus 로고    scopus 로고
    • Off-target transcript silencing mediated by seed region sequence complementarity
    • Jackson, A. L. et al. Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA 12, 1179-1187 (2006).
    • (2006) RNA , vol.12 , pp. 1179-1187
    • Jackson, A.L.1    Widespread Sirna, E.2
  • 64
    • 29144505309 scopus 로고    scopus 로고
    • The widespread impact of mammalian MicroRNAs on mRNA repression and evolution
    • Farh, K. K. et al. The widespread impact of mammalian MicroRNAs on mRNA repression and evolution. Science 310, 1817-1821 (2005).
    • (2005) Science , vol.310 , pp. 1817-1821
    • Farh, K.K.1
  • 65
    • 33745614074 scopus 로고    scopus 로고
    • Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing
    • Jackson, A. L. et al. Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA 12, 1197-1205 (2006).
    • (2006) RNA , vol.12 , pp. 1197-1205
    • Jackson, A.L.1
  • 66
    • 58049213696 scopus 로고    scopus 로고
    • Dicer, Drosha, and outcomes in patients with ovarian cancer
    • Merritt, W. M. et al. Dicer, Drosha, and outcomes in patients with ovarian cancer. N. Engl. J. Med. 359, 2641-2650 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 2641-2650
    • Merritt, W.M.1
  • 67
    • 33745299723 scopus 로고    scopus 로고
    • Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
    • Grimm, D. et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441, 537-541 (2006).
    • (2006) Nature , vol.441 , pp. 537-541
    • Grimm, D.1
  • 68
    • 34548548614 scopus 로고    scopus 로고
    • Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC
    • Castanotto, D. et al. Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC. Nucleic Acids Res. 35, 5154-5164 (2007).
    • (2007) Nucleic Acids Res. , vol.35 , pp. 5154-5164
    • Castanotto, D.1
  • 69
    • 67149115119 scopus 로고    scopus 로고
    • Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
    • Khan, A. A. et al. Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nature Biotech. 27, 549-555 (2009).
    • (2009) Nature Biotech. , vol.27 , pp. 549-555
    • Khan, A.A.1
  • 70
    • 3042602447 scopus 로고    scopus 로고
    • Kinetic analysis of the RNAi enzyme complex
    • Haley, B. & Zamore, P. D. Kinetic analysis of the RNAi enzyme complex. Nature Struct. Mol. Biol. 11, 599-606 (2004).
    • (2004) Nature Struct. Mol. Biol. , vol.11 , pp. 599-606
    • Haley, B.1    Zamore, P.D.2
  • 72
    • 34748924187 scopus 로고    scopus 로고
    • Chemically modified siRNA prolonged RNA interference in renal disease
    • Takabatake, Y. et al. Chemically modified siRNA prolonged RNA interference in renal disease. Biochem. Biophys. Res. Commun. 363, 432-437 (2007).
    • (2007) Biochem. Biophys. Res. Commun. , vol.363 , pp. 432-437
    • Takabatake, Y.1
  • 73
    • 31544456413 scopus 로고    scopus 로고
    • Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging
    • Bartlett, D. W. & Davis, M. E. Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res. 31, 322-333 (2006).
    • (2006) Nucleic Acids Res. , vol.31 , pp. 322-333
    • Bartlett, D.W.1    Davis, M.E.2
  • 74
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • Duncan, R. The dawning era of polymer therapeutics. Nature Rev. Drug Discov. 2, 347-360 (2003).
    • (2003) Nature Rev. Drug Discov. , vol.2 , pp. 347-360
    • Duncan, R.1
  • 75
    • 68049144915 scopus 로고    scopus 로고
    • Dual targeting of EphA2 and FAK in ovarian carcinoma
    • Shahzad, M. M. K. et al. Dual targeting of EphA2 and FAK in ovarian carcinoma. Cancer Biol. Ther. 8, 1027-1034 (2009).
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 1027-1034
    • Shahzad, M.M.K.1
  • 76
    • 33746786005 scopus 로고    scopus 로고
    • Chemically modified short interfering hybrids (siHYBRIDS): Nanoimmunoliposome delivery in vitro and in vivo for RNAi of HER-2
    • Hogrefe, R. I. et al. Chemically modified short interfering hybrids (siHYBRIDS): nanoimmunoliposome delivery in vitro and in vivo for RNAi of HER-2. Nucleosides Nucleotides Nucleic Acids 25, 889-907 (2006).
    • (2006) Nucleosides Nucleotides Nucleic Acids , vol.25 , pp. 889-907
    • Hogrefe, R.I.1
  • 77
    • 77949632782 scopus 로고    scopus 로고
    • Frontiers in cancer nanomedicine: Directing mass transport through biological barriers
    • Ferrari, M. Frontiers in cancer nanomedicine: directing mass transport through biological barriers. Trends Biotech. 28, 181-188 (2010).
    • (2010) Trends Biotech. , vol.28 , pp. 181-188
    • Ferrari, M.1
  • 78
    • 77953448762 scopus 로고    scopus 로고
    • Nanoparticle-aptamer conjugates for cancer cell targeting and detection
    • Estévez, M. C. et al. Nanoparticle-aptamer conjugates for cancer cell targeting and detection. Methods Mol. Biol. 624, 235-248 (2010).
    • (2010) Methods Mol. Biol. , vol.624 , pp. 235-248
    • Estévez, M.C.1
  • 79
    • 31544448890 scopus 로고    scopus 로고
    • Comparative evaluation of target-specific GFP gene silencing efficiencies for antisense ODN, synthetic siRNA, and siRNA plasmid complexed with PEI-PEG-FOL conjugate
    • Kim, S. H., Mok, H., Jeong, J. H., Kim, S. W. & Park, T. G. Comparative evaluation of target-specific GFP gene silencing efficiencies for antisense ODN, synthetic siRNA, and siRNA plasmid complexed with PEI-PEG-FOL conjugate. Bioconjug. Chem. 17, 241-244 (2006).
    • (2006) Bioconjug. Chem. , vol.17 , pp. 241-244
    • Kim, S.H.1    Mok, H.2    Jeong, J.H.3    Kim, S.W.4    Park, T.G.5
  • 80
    • 77953171176 scopus 로고    scopus 로고
    • Targeted nanoparticles that deliver a sustained, specific release of paclitaxel to irradiated tumors
    • Passarella, R. J. et al. Targeted nanoparticles that deliver a sustained, specific release of paclitaxel to irradiated tumors. Cancer Res. 70, 4550-4559 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 4550-4559
    • Passarella, R.J.1
  • 81
    • 77951699994 scopus 로고    scopus 로고
    • Sustained small interfering RNA delivery by mesoporous silicon particles
    • Tanaka, T. et al. Sustained small interfering RNA delivery by mesoporous silicon particles. Cancer Res. 70, 3687-3696 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 3687-3696
    • Tanaka, T.1
  • 82
    • 36049049737 scopus 로고    scopus 로고
    • Design maps for nanoparticles targeting the diseased microvasculature
    • Decuzzi, P. & Ferrari, M. Design maps for nanoparticles targeting the diseased microvasculature. Biomaterials 29, 377-384 (2008).
    • (2008) Biomaterials , vol.29 , pp. 377-384
    • Decuzzi, P.1    Ferrari, M.2
  • 83
    • 38849102949 scopus 로고    scopus 로고
    • The mathematical engines of nanomedicine
    • Ferrari, M. The mathematical engines of nanomedicine. Small 4, 20-25 (2008).
    • (2008) Small , vol.4 , pp. 20-25
    • Ferrari, M.1
  • 84
    • 33750715409 scopus 로고    scopus 로고
    • Mathematical modeling of cancer progression and response to chemotherapy
    • Sanga, S. et al. Mathematical modeling of cancer progression and response to chemotherapy. Expert Rev. Anticancer Ther. 6, 1361-1376 (2006).
    • (2006) Expert Rev. Anticancer Ther. , vol.6 , pp. 1361-1376
    • Sanga, S.1
  • 85
    • 0034996764 scopus 로고    scopus 로고
    • Long-circulating and target-specific nanoparticles: Theory to practice
    • Moghimi, S. M., Hunter, A. C. & Murray, J. C. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev. 53, 283-318 (2001).
    • (2001) Pharmacol. Rev. , vol.53 , pp. 283-318
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 86
    • 51049092308 scopus 로고    scopus 로고
    • Factors affecting the clearance and biodistribution of polymeric nanoparticles
    • Alexis, F., Pridgen, E., Molnar, L. K. & Farokhzad, O. C. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharm. 5, 505-515 (2008).
    • (2008) Mol. Pharm. , vol.5 , pp. 505-515
    • Alexis, F.1    Pridgen, E.2    Molnar, L.K.3    Farokhzad, O.C.4
  • 87
    • 4444272419 scopus 로고    scopus 로고
    • Dose-finding based on efficacy-toxicity trade-offs
    • Thall, P. F. & Cook, J. D. Dose-finding based on efficacy-toxicity trade-offs. Biometrics 60, 684-693 (2004).
    • (2004) Biometrics , vol.60 , pp. 684-693
    • Thall, P.F.1    Cook, J.D.2
  • 88
    • 0012392952 scopus 로고    scopus 로고
    • Semiconductor nanocrystals as fluorescent biological labels
    • Bruchez, M. J., Moronne, M., Gin, P., Weiss, S. & Alivisatos, A. P. Semiconductor nanocrystals as fluorescent biological labels. Science 281, 2013-2016 (1998).
    • (1998) Science , vol.281 , pp. 2013-2016
    • Bruchez, M.J.1    Moronne, M.2    Gin, P.3    Weiss, S.4    Alivisatos, A.P.5
  • 89
    • 33845975678 scopus 로고    scopus 로고
    • Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference
    • Tan, W. B., Jiang, S. & Zhang, Y. Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference. Biomaterials 28, 1565-1571 (2007).
    • (2007) Biomaterials , vol.28 , pp. 1565-1571
    • Tan, W.B.1    Jiang, S.2    Zhang, Y.3
  • 90
    • 79951814213 scopus 로고    scopus 로고
    • Quantum dots as contrast agents for in vivo tumor imaging: Progress and issues
    • Jul doi:10.1007/s00216-010-4010-3
    • Tavares, A. J., Chong, L., Petryayeva, E., Algar, W. R. & Krull, U. J. Quantum dots as contrast agents for in vivo tumor imaging: progress and issues. Anal. Bioanal. Chem. 25 Jul 2010 (doi:10.1007/ s00216-010-4010-3).
    • (2010) Anal. Bioanal. Chem , vol.25
    • Tavares, A.J.1    Chong, L.2    Petryayeva, E.3    Algar, W.R.4    Krull, U.J.5
  • 91
    • 75749154476 scopus 로고    scopus 로고
    • In vivo imaging of RNA interference
    • Hong, H., Zhang, Y. & Cai, W. In vivo imaging of RNA interference. J. Nucl. Med. 51, 169-172 (2010).
    • (2010) J. Nucl. Med. , vol.51 , pp. 169-172
    • Hong, H.1    Zhang, Y.2    Cai, W.3
  • 92
    • 0033760396 scopus 로고    scopus 로고
    • Telomerase RNA as a detection marker in the serum of breast cancer patients
    • Chen, X. Q. et al. Telomerase RNA as a detection marker in the serum of breast cancer patients. Clin. Cancer Res. 6, 3823-3826 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 3823-3826
    • Chen, X.Q.1
  • 93
    • 0032802166 scopus 로고    scopus 로고
    • Detection of tumor messenger RNA in the serum of patients with malignant melanoma
    • Kopreski, M. S., Benko, F. A., Kwak, L. W. & Gocke, C. D. Detection of tumor messenger RNA in the serum of patients with malignant melanoma. Clin. Cancer Res. 5, 1961-1965 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1961-1965
    • Kopreski, M.S.1    Benko, F.A.2    Kwak, L.W.3    Gocke, C.D.4
  • 94
    • 33847129200 scopus 로고    scopus 로고
    • Circulating (cell-free) nucleic acids - A promising non-invasive tool for early detection of several human diseases
    • Swarup, V. & Rajeswari, M. R. Circulating (cell-free) nucleic acids - a promising, non-invasive tool for early detection of several human diseases. FEBS J. 581, 795-799 (2007).
    • (2007) FEBS J. , vol.581 , pp. 795-799
    • Swarup, V.1    Rajeswari, M.R.2
  • 95
    • 70349633095 scopus 로고    scopus 로고
    • RNAi and iTRAQ reagents united: Targeted quantitation of siRNA-mediated protein silencing in human cells
    • Abdrakhmanova, A. et al. RNAi and iTRAQ reagents united: targeted quantitation of siRNA-mediated protein silencing in human cells. Anal. Bioanal. Chem. 395, 773-785 (2009).
    • (2009) Anal. Bioanal. Chem. , vol.395 , pp. 773-785
    • Abdrakhmanova, A.1
  • 96
    • 33846631884 scopus 로고    scopus 로고
    • Common genetic variants account for differences in gene expression among ethnic groups
    • Spielman, R. S. et al. Common genetic variants account for differences in gene expression among ethnic groups. Nature Genet. 39, 226-231 (2007).
    • (2007) Nature Genet. , vol.39 , pp. 226-231
    • Spielman, R.S.1
  • 97
    • 77950822671 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility
    • Nicoloso, M. S. et al. Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. Cancer Res. 70, 2789-2798 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 2789-2798
    • Nicoloso, M.S.1
  • 98
    • 77950843538 scopus 로고    scopus 로고
    • The dicey role of Dicer: Implications for RNAi therapy
    • Merritt, W. M., Bar-Eli, M. & Sood, A. K. The dicey role of Dicer: implications for RNAi therapy. Cancer Res. 70, 2571-2574 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 2571-2574
    • Merritt, W.M.1    Bar-Eli, M.2    Sood, A.K.3
  • 99
    • 48249097174 scopus 로고    scopus 로고
    • Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites
    • Diederichs, S. et al. Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites. Proc. Natl Acad. Sci. USA 105, 9284-9289 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 9284-9289
    • Diederichs, S.1


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