N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles

Journal of Controlled Release

Volumn 72, Issue 1-3, 2001, Pages 71-84

  Leroux, Jean Christophe ^a   Roux, Emmanuelle ^a   Le Garrec, Dorothée ^a   Hong, Keelung ^b   Drummond, Daryl C ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

pH Sensitive liposomes; pH responsive; Photodynamic therapy; Poly(N isopropylacrylamide); Polymeric micelles

Indexed keywords

ANTINEOPLASTIC AGENT; CHLOROALUMINUM PHTHALOCYANINE; COPOLYMER; CREMOPHOR; DOXORUBICIN; LIPOSOME; MACROGOL; N ISOPROPYLACRYLAMIDE COPOLYMMER; PHOSPHATIDYLCHOLINE; POLYMER; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SYNTHESIS; FLUORESCENCE; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; MICELLE; PH; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL;

ACRYLAMIDES; ANIMALS; COLLOIDS; DRUG CARRIERS; HYDROGEN-ION CONCENTRATION; INDOLES; LIPOSOMES; MICE; MICELLES; MOLECULAR WEIGHT; PARTICLE SIZE; PHOTOSENSITIZING AGENTS; POLYMERS; POROSITY; SOLUBILITY; TUMOR CELLS, CULTURED;

EID: 0035858327     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00263-2     Document Type: Article

References (87)

1. pH-sensitive nanoparticles: An effective means to improve the oral delivery of HIV-1 protease inhibitors in dogs
2. Electrically erodible polymer gel for controlled release of drugs
3. Liposomes and hyperthermia in mice: Increased tumor uptake and therapeutic efficacy of doxorubicin in sterically stabilized liposomes
4. Ultrasound-enhanced polymer degradation and release of incorporated substances
5. Cytosolic drug delivery using pH- and light-sensitive liposomes
6. pH-sensitive liposomes: Possible clinical implications
7. pH-induced destabilization of phosphatidylethanolamine-containing liposomes: Role of bilayer contact
8. Proton-induced fusion of oleic acid-phosphatidylethanolamine liposomes
9. pH-sensitive liposomes mediate cytoplasmic delivery of encapsulated macromolecules
10. Modifications of the acid-base status of the internal milieu of tumors
11. Extracellular pH distribution in human tumours
12. pH-sensitive immunoliposomes mediate target-cell-specific delivery and controlled expression of a foreign gene in mouse
13. Phosphatidylethanolamine liposomes: Drug delivery, gene transfer and immunodiagnostic applications
14. Cytotoxicity of diphteria toxin A fragment to toxin-resistant murine cells delivered by pH-sensitive immunoliposomes
15. Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer
16. Endocytosis of liposomes and intracellular fate of encapsulated molecules: Encounter with a low pH compartment after internalization in coated vesicles
17. Interactions of immunoliposomes with target cells
18. Effects of ammonium chloride and chloroquine on endocytic uptake of liposomes by kupffer cells in vitro
19. Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes
20. Generation of pH-sensitive liposomes: Use of large unilamellar vesicles containing N-succinyldioleoylphosphatidylethanolamine
21. pH-sensitive immunoliposomes as an efficient and target-specific carrier for antitumor drugs
22. Efficiency of cytoplasmic delivery by pH-sensitive liposomes to cells in culture
23. pH-sensitive liposomes provide an efficient means of sensitizing target cells to class I restricted CTL recognition of a soluble protein
24. Delivery of macromolecules into cytosol using liposomes containing hemolysin from Listeria monocytogenes
25. pH-sensitive liposomes: An intelligent system for the delivery of antisense oligonucleotides
26. pH-sensitive, cationic liposomes: A new synthetic virus-like vector
27. Role of cholesterol in the stability of pH-sensitive, large unilamellar liposomes prepared by the detergent-dialysis method
28. Biodistribution of immunoliposomes
29. Small, but not large, unilamellar liposomes composed of dioleoylphosphatidylethanolamine and oleic acid can be stabilized by human plasma
30. Interactions of serum proteins with small unilamellar liposomes composed of dioleoylphosphatidylethanolamine and oleic acid: High density lipoproteins, apoliporotein A1, and amphipatic peptides stabilize liposomes
31. pH-dependent stability and fusion of liposomes combining protonatable double-chain amphiphiles with phosphatidylethanolamine
32. Structural and functional comparisons of pH-sensitive liposomes composed of phosphatidylethanolamine and three different diacylsuccinylglycerols
33. Proton-induced permeability and fusion of large unilamellar vesicles by covalently conjugated poly(2-ethylacrylic acid)
34. Temperature-sensitive liposomes: Liposomes bearing poly(N-isopropylacrylamide)
35. pH-sensitization of phospholipid vesicles via complexation with synthetic poly(carboxylic acid)
36. +-induced release of contents of phosphatidylcholine vesicles bearing surface-bound polyelectrolyte chains
37. Preparation and characterization of pH-responsive polymeric micelles for the delivery of anticancer photosensitizing drugs
38. Polymeric micelles - A new generation of colloidal drug carriers
39. Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxide-aspartate) block copolymer-adriamycin conjugates
40. New macromolecular carriers for drugs. I. Preparation and characterization of poly(oxyethylene-β-isoprene-β-oxyethylene) block copolymer aggregates
41. Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate)
42. Solution properties of poly(N-isopropylacrylamide)
43. Temperature-controlled release property of phospholipid vesicles bearing a thermo-sensitive polymer
44. Temperature-sensitivity of liposomal lipid bilayers mixed with poly(N-isopropylacrylamide)
45. Volume-phase transitions of ionized N-isopropylacrylamide gels
46. Graft polymers that exibit temperature-induced phase transitions over a wide range of pH
47. A novel approach for preparation of pH-sensitive hydrogels for enteric drug delivery
48. Pulsatile local delivery of thrombolytic and antithrombotic agents using poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels
49. pH/Temperature-sensitive polymers for macromolecular drug loading and release
50. In vitro characterization of a novel pH-sensitive liposome system
51. Amphiphilic poly(N-isopropylacrylamides) prepared by using a lipophilic radical initiator: Synthesis and solution properties in water
52. pH-responsive liposomes which contain amphiphiles prepared by using lipophilic radical initiator
53. Inverse thermally-reversible gelation of aqueous N-isopropylacrylamide copolymer solutions
54. Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes
55. Copolymers of N-isopropylacrylamide can trigger pH sensitivity to stable liposomes
56. 2-macroglobulin
57. Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapement of amphipathic weak bases
58. Poly(styrene-ethylene oxide) block copolymer micelle formation in water: A fluorescence probe study
59. Critical micellization phenomena in block polyelectrolyte solutions
60. An improved colorimetric assay for interleukin 2
61. Effect of molecular architecture of hydrophobically modified poly(N-isopropylacrylamide) on the formation of thermoresponsive core-shell micellar drug carriers
62. Molecular mechanism of the lipid vesicle longevity in vivo
63. Poly(ethylene glycol) on the liposome surface: On the mechanism of polymer-coated liposome longevity
64. A polymeric 'flippase' for surface-differentiated dipalmitoylphosphatidylcholine liposomes
65. Serum-induced leakage of liposome contents
66. Modification of liposomes with N-substituted polyacrylamides: Identification of proteins adsorbed from plasma
67. pH-sensitive gel phase liposomes
68. Sterically stabilized liposomes: A hypothesis on the molecular origin of the extended circulation times
69. The use of glycolipids and hydrophilic polymers in avoiding rapid uptake of liposomes by the mononuclear phagocyte systems
70. Polymer-grafted liposomes: Physical basis for the 'stealth' properties
71. On the molecular mechanism of steric stabilization of liposomes in biological fluids
72. Sterically stabilized liposomes: Improvement in pharmacokinetics and antitumor therapeutic efficacy
73. Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors
74. Sterically stabilized liposomes: Physical and biological properties
75. Some negatively charged phospholipid derivatives prolong the liposome circulation in vivo
76. Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection
77. Versatility in lipid compositions showing prolonged circulation with sterically stabilized liposomes
78. Sterically stabilized liposomes
79. Controlled destabilization of a liposomal drug delivery system enhances mitoxantrone antitumor activity
80. Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents
81. Endocytosis of liposomes by macrophages: Binding, acidification and leakage of liposomes monitored by a new fluorescence assay
82. Hydrophobically-modified poly(N-isopropylacrylamides) in water: Probing of the microdomain composition by nonradiative energy transfer
83. Polycaprolactone-β-poly(ethylene oxide) block copolymer micelles as a novel drug delivery vehicle for neutrotrophic agents KK506 and L-685,818
84. Preparation and characterization of the micelle-forming polymeric drug indomethacin-incorporated poly(ethylene oxide)-poly(β-benzyl l-aspartate) block copolymer micelles
85. 44 block copolymer micelles
86. Photodynamic efficiency of protoporphyrin IX: Comparison of endogenous protoporphyrin IX induced by 5-aminolevulinic acid and exogenous porphyrin IX
87. In vitro and in vivo evaluation of pH-responsive polymeric micelles in a cancer photodynamic therapy model