Systemic delivery of siRNA by actively targeted polyion complex micelles for silencing the E6 and E7 human papillomavirus oncogenes

Journal of Controlled Release

Volumn 231, Issue , 2016, Pages 29-37

  Nishida, Haruka ^a   Matsumoto, Yoko ^a   Kawana, Kei ^a   Christie, R James ^a   Naito, Mitsuru ^a   Kim, Beob Soo ^b   Toh, Kazuko ^a   Min, Hyun Su ^b   Yi, Yu ^b   Matsumoto, Yu ^a   Kim, Hyun Jin ^a   Miyata, Kanjiro ^a,b   Taguchi, Ayumi ^a   Tomio, Kensuke ^a   Yamashita, Aki ^a   Inoue, Tomoko ^a   Nakamura, Hiroe ^a   Fujimoto, Asaha ^a   Sato, Masakazu ^a   Yoshida, Mitsuyo ^a   Adachi, Katsuyuki ^a   Arimoto, Takahide ^a   Wada Hiraike, Osamu ^a   Oda, Katsutoshi ^a   Nagamatsu, Takeshi ^a   Nishiyama, Nobuhiro ^c,d   Kataoka, Kazunori ^a,b,d   Osuga, Yutaka ^a   Fujii, Tomoyuki ^a   more..

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^d KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION   (Japan)

Author keywords

Cervical cancer; Drug delivery system; Human papillomavirus (HPV) E6 E7; Polyion complex (PIC) micelle; Small interfering RNA (siRNA)

Indexed keywords

CELL CULTURE; CELLS; DISEASES; FLUORESCENCE; MAMMALS; MICELLES; RNA; TUMORS;

CERVICAL CANCERS; DRUG DELIVERY SYSTEM; HUMAN PAPILLOMAVIRUS; POLYION COMPLEX MICELLES; SMALL INTERFERING RNA (SIRNA);

ONCOGENIC VIRUSES;

CASPASE 3; CASPASE 7; DRUG CARRIER; FLUORESCENT DYE; POLYION COMPLEX MICELLE; POLYMER; PROTEIN E6; PROTEIN E7; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 16; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 18; E7 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 18; MACROGOL DERIVATIVE; ONCOGENE PROTEIN E7, HUMAN PAPILLOMAVIRUS TYPE 16; ONCOPROTEIN; POLYLYSINE; REPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; CELL PROLIFERATION; CELL VIABILITY ASSAY; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; FLUORESCENCE IMAGING; GENE SILENCING; HELA CELL LINE; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; IN VITRO STUDY; IN VIVO STUDY; MICELLE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA EXTRACTION; UTERINE CERVIX CANCER; VIRUS ONCOGENE; WART VIRUS; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; GENE EXPRESSION; GENETICS; METABOLISM; NUDE MOUSE; PAPILLOMAVIRIDAE; PATHOLOGY; SCID MOUSE; TUMOR CELL LINE; UTERINE CERVIX TUMOR; VIROLOGY; XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; DRUG CARRIERS; FEMALE; GENE EXPRESSION; GENE SILENCING; HETEROGRAFTS; HUMANS; MICE, INBRED BALB C; MICE, NUDE; MICE, SCID; MICELLES; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS E7 PROTEINS; POLYETHYLENE GLYCOLS; POLYLYSINE; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53; UTERINE CERVICAL NEOPLASMS;

EID: 84977955875     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.03.016     Document Type: Article

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