Long-circulating poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles with modulated surface charge

Journal of Controlled Release

Volumn 77, Issue 1-2, 2001, Pages 27-38

  Yamamoto, Yuji ^a   Nagasaki, Yukio ^b   Kato, Yukio ^a   Sugiyama, Yuichi ^a   Kataoka, Kazunori ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Biodistribution; Block copolymer micelles; Peptidyl ligand; Poly(D,L lactide); Poly(ethylene glycol)

Indexed keywords

COPOLYMER; FUNCTIONAL GROUP; GLUTAMIC ACID; LIGAND; MACROGOL; PEPTIDE; POLY(ETHYLENE GLYCOL) POLY(LACTIDE) TYROSINE CONJUGATE; POLY(ETHYLENE GLYCOL) POLY(LACTIDE) TYROSYLGLUTAMIC ACID CONJUGATE; POLYLACTIDE; TYROSINE; UNCLASSIFIED DRUG;

AMINATION; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CIRCULATION; CONJUGATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GEL FILTRATION; LIVER FUNCTION; MALE; MICELLE; MOUSE; NONHUMAN; ORGAN BLOOD FLOW; PRIORITY JOURNAL; SPLEEN FUNCTION; SURFACE CHARGE; SUSTAINED DRUG RELEASE;

DRUG CARRIERS; MICELLES; MOLECULAR WEIGHT; POLYESTERS; POLYETHYLENE GLYCOLS; TISSUE DISTRIBUTION;

EID: 0035834269     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00451-5     Document Type: Article

References (56)

1. The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles: Micelles as microcontainers for drug targeting
2. Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer
3. Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood
4. Block copolymer micelles as vehicles for drug delivery
5. Biodistribution of micelle-forming polymer-drug conjugate
6. Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxide-aspartate) block copolymer-adriamycin conjugate
7. Selective delivery of adriamycin to a solid tumor using a polymeric micelle carrier system
8. Block copolymer micelles for drug delivery: Design, characterization and biological significance
9. A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
10. PEG-poly(lysine) block copolymer as a novel type of synthetic gene vector with supramolecular structure
11. Characterization of vector for gene therapy formed by self-assembly of DNA with synthetic block co-polymer
12. Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer
13. Water-soluble block polycations as carriers for oligonucleotide delivery
14. Spontaneous formation of polyion complex micelles with narrow distribution from antisence oligonucleotide and cationic block copolymer in physiological saline
15. Novel polyion complex micelles entrapping enzyme molecules in the core: Preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block copolymer in aqueous medium
16. Peptide drug carrier: Studies on incorporation of vasopressin into nano-associates comprising poly(ethylene glycol)-poly(L-aspartic acid) block copolymer
17. Preparation and characterization of self-assembled polymer-metal complex micelles from cis-dichlorodiammineplatinum(II) and poly(ethylene glycol)-poly(αβ-aspartic acid) block copolymer in an aqueous medium
18. Synthesis and properties of biodegradable ABA triblock copolymers consisting of poly(L-lactic acid) or poly(L-lactic-co-glycolic acid) A-blocks attached to central poly(oxyethylene) B-blocks
19. Novel PDLLA/PEG copolymer micelles as drug carriers
20. Effect of PEO surface density on long-circulating PLA-PEO nanoparticles which are very low complement activators
21. Development of amphiphilic diblock copolymers as micellar carriers of taxol
22. PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics
23. Association and surface properties of diblock copolymers of ethylene oxide and DL-lactide in aqueous solution
24. Preparation of nanoparticles consisted of poly(L-lactide)-poly(ethylene glycol)-poly(L-lactide) and their evaluation in vitro
25. Colloidal stability and drug incorporation aspects of micellar-like PLA-PEG nanoparticles
26. Preparation and characterization of polymer micelles from poly(ethylene glycol)-poly(D,L-lactide) block polymers as potential drug carrier
27. Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers
28. Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system
29. Polylactide-poly(ethylene glycol) copolymers as drug delivery systems. 1. Characterization of water dispersible micelle-forming system
30. Evaluation of long-circulating nanoparticles using biodegradable ABA triblock copolymers containing of poly(L-lactic acid) A-blocks attached to central poly(oxyethylene) B-blocks in vivo
31. Development of copolymers of poly(D,L-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel
32. Biodegradable long-circulating polymeric nanospheres
33. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposome
34. Liposomes for the sustained drug release in vivo
35. Liposome containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
36. Sodium naphthalene. I. A new method for the preparation of addition compounds of alkali metals and polycyclic aromatic hydrocarbons
37. A novel reactive polymeric micelle with aldehyde groups on its surface
38. The reactive polymeric micelle based on an aldehyde-ended poly(ethylene glycol)/poly(lactide) block copolymer
39. Surface charge modulation of poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles: Conjugation of charged peptide
40. Direct determination of plasma, cell, and organ-blood volumes in normal and hypervolemic mice
41. Sterically stabilized liposomes: Improvements in pharmacokinetics and antitumor therapeutic efficacy
42. Pharmacokinetics of stealth versus conventional liposomes: Effect of dose
43. Versatility in lipid composition showing prolonged circulation with sterically stabilized liposome
44. Transport of molecules in the tumor intestitium: A review
45. Determinants of tumor blood flow: A review
46. Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice
47. Size and shape of globular micelles formed in aqueous solution by n-alkyl polyoxyethylene ethers
48. Light-scattering study of the association behavior of styrene-ethylene oxide block copolymers in aqueous solution
49. Effect of molecular weight in amphipatic polyethyleneglycol on prolonging the circulation time of large unilamellar liposomes
50. Disposition characteristics of macromolecules in tumor-bearing mice
51. Macromolecular carrier systems for targeted drug delivery: Pharmacokinetic considerations on biodistribution
52. w) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats
53. A study of micelles in a base lubricating oil by gel permeation chromatography
54. The effect of solute size and shape on the elution volume in size exclusion chromatography
55. Size-exclusion chromatography of micellar solutions of poly(oxyethylene) n-alkyl ethers