Methotrexate esters of poly(ethylene oxide)-block-poly(2-hydroxyethyl-L- aspartamide). Part I: Effects of the level of methotrexate conjugation on the stability of micelles and on drug release

Pharmaceutical Research

Volumn 17, Issue 5, 2000, Pages 607-611

  Li, Yu ^a   Kwon, Glen S ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Block copolymer; Drug delivery; Methotrexate; Micelles; Polymeric conjugate; Unimers

Indexed keywords

ASPARTIC ACID; ESTER; MACROGOL; METHOTREXATE DERIVATIVE;

ARTICLE; DISSOCIATION; DRUG CONJUGATION; DRUG RELEASE; DRUG STRUCTURE; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; LIGHT SCATTERING; MICELLE; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; ASPARTIC ACID; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; METHOTREXATE; MICELLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; SOLUBILITY;

EID: 0034096245     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007529218802     Document Type: Article

References (15)

1. 1. C. Allen, Y. Yu, D. Maysinger, and A. Eisenberg. Polycaprolactone-b-poly(ethylene oxide) block copolymer micelles as a novel drug delivery vehicle for neurotrophic agents FK506 and L-685,818. Bioconjugate Chem. 9:564-572 (1998).
2. 2. K. Kataoka, G. S. Kwon, M. Yokoyama, T. Okano, and Y. Sakurai. Block copolymer micelles as vehicles for drug delivery. J. Controlled Release. 24:119-132 (1993).
3. 3. X. Zhang, J. K. Jackson, and H. M. Burt. Development of amphiphilic diblock copolymers as micellar carriers of taxol. Int. J. Pharm. 132:195-206 (1996).
4. 4. G. S. Kwon, M. Naito, M. Yokoyama, T. Okano, Y. Sakurai, and K. Kataoka. Micelles based on ab block copolymers of poly(ethylene oxide) and poly(β-benzyl l-aspartate). Langmuir 9:945-949 (1993).
5. 5. K. Kataoka. Targetable polymeric drugs. In K. Park (ed.) Controlled Drug Delivery: Challenges and Strategies, American Chemical Society, Washington, D.C., 1997, pp. 49-71 (1997).
6. 6. M. Y. Gorshkova and L. L. Stotskaya. Micelle-like macromolecular systems for controlled release of daunomycin. Polymers for Advanced Technologies 9:362-367 (1998).
7. 7. M. Yokoyama, T. Sugiyama, T. Okano, Y. Sakurai, M. Naito, and K. Kataoka. Analysis of micelle formation of an adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer by gel permeation chromatography. Pharm. Res. 10:895-899 (1993).
8. 8. R. Nagarajan, M. Barry, and E. Ruckenstein. Unusual selectivity in solubilization by block copolymer micelles. Langmuir 2:210-215 (1986).
9. 9. G. S. Kwon, M. Y. Suwa, T. Okano, Y. Sakurai, and K. Kataoka. Physical entrapment of adriamycin in ab block copolymer micelles. Pharm. Res. 12:192-195 (1995).
10. 10. M. Yokoyama, T. Okano, Y. Sakurai, H. Ekimoto, C. Skibazaki, and K. Kataoka. Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res. 29:17-23 (1991).
11. 11. Y. Li and G. S. Kwon. Micelle-like structures of poly(ethylene oxide)-block-poly(2-hydroxyethyl aspartamide)-methotrexate conjugates. Colloids Surf. B: Biointerfaces 16:217-226 (1999).
12. 12. M. Yokoyama, S. Inoue, K. Kataoka, N. Yui, and Y. Sakurai. Preparation of adriamycin-conjugated poly(ethylene glycol)-poly-(aspartic acid) block copolymer: a new type of polymeric anticancer drug. Macromol. Chem. Rapid Commun. 8:431-435 (1987).
13. 13. L. Zhang, H. Shen, and A. Eisenberg. Phase separation behavior and crew cut micelle formation of polystyrene-b-poly(acrylic acid) copolymer in solutions. Macromolecules 30:1001-1011 (1997).
14. 14. P. Tancrede, J. Barwicz, S. Jutras, and I. Gruda. The effect of surfactants on the aggregation state of amphotericin B. Biochim.-Biophys. Acta 1030:289-295 (1990).
15. 15. N. J. Yurro, M. Gratzel, and A. M. Braun. Photochemical processes in micellar system Angew. Chem. Int. Ed. Engl. 19:675-696 (1980).