The effect of kinetic stability on biodistribution and anti-tumor efficacy of drug-loaded biodegradable polymeric micelles

Biomaterials

Volumn 34, Issue 12, 2013, Pages 3132-3140

  Ebrahim Attia, Amalina B ^a   Yang, Chuan ^a   Tan, Jeremy P K ^a   Gao, Shujun ^a   Williams, David F ^b   Hedrick, James L ^c   Yang, Yi Yan ^a  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c IBM ALMADEN RESEARCH CENTER   (United States)

Author keywords

Anti tumor activity; Biodistribution; Functional polycarbonates; Kinetic stability; Micelles

Indexed keywords

ANTI-TUMOR ACTIVITIES; ANTI-TUMOR EFFICACY; ANTICANCER DRUG; BIODISTRIBUTIONS; BODY WEIGHT; BREAST CANCER MODELS; BURST RELEASE; CARDIOTOXICITY; DOXORUBICIN; IN-VITRO; IN-VIVO; KINETIC STABILITY; LOADING LEVEL; MACROINITIATORS; METHOXY; MIXED MICELLES; NARROW SIZE DISTRIBUTIONS; ORGANOCATALYTIC; POLYDISPERSITY INDICES; POLYMERIC MICELLE; SELF ASSEMBLY PROCESS; TUMOR GROWTH;

BLOCK COPOLYMERS; DRUG PRODUCTS; HYDROGEN BONDS; KINETICS; MANGANESE; METABOLISM; MICELLES; POLYCARBONATES; POLYETHYLENE OXIDES; SIZE DISTRIBUTION; STABILITY; TUMORS; UREA;

POLYETHYLENE GLYCOLS;

AMINE; DOXORUBICIN; HYDROGEN; MACROGOL; POLYCARBONATE; POLYMER; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CATALYSIS; CELL LINE; CELL STRAIN HEPG2; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG STABILITY; HYDROGEN BOND; HYDROPHOBICITY; MICELLE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; RING OPENING; SUSTAINED DRUG RELEASE;

ANTINEOPLASTIC AGENTS; BIOCOMPATIBLE MATERIALS; CELL LINE, TUMOR; DOXORUBICIN; DRUG CARRIERS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MICELLES; NEOPLASMS, EXPERIMENTAL; PARTICLE SIZE; TISSUE DISTRIBUTION;

EID: 84873453625     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.01.042     Document Type: Article

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