Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b- poly(D,L-lactide-co-glycolide) with varying compositions

Biomaterials

Volumn 26, Issue 24, 2005, Pages 5064-5074

  Liu, S Q ^a,b   Tong, Y W ^b   Yang, Yi Yan ^a  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Doxorubicin; Drug release; P(NIPAAm co DMAAm); PLGA; Thermally sensitive micelles

Indexed keywords

BLOCK COPOLYMERS; DRUG PRODUCTS; LIGHT SCATTERING; NUCLEAR MAGNETIC RESONANCE; SYNTHESIS (CHEMICAL); TOXICITY; TRANSMISSION ELECTRON MICROSCOPY; TUMORS;

CRITICAL ASSOCIATION CONCENTRATION (CAC); DOXORUBICIN; LOWER CRITICAL SOLUTION TEMPERATURE (LCST); PHOSPHATE-BUFFERED SOLUTION (PBS);

MICELLES;

BUFFER; CARBON; DOXORUBICIN; DRUG CARRIER; PHOSPHATE; POLY(N ISOPROPYLACRYLAMIDE CO N, N DIMETHYLACRYLAMIDE) B POLY(DEXTRO,LEVO LACTIDE CO GLYCOLIDE); POLYGLACTIN; POLYLACTIDE; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL NUCLEUS; CONFOCAL LASER MICROSCOPY; CYTOPLASM; CYTOTOXICITY; DEGRADATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENDOCYTOSIS; LIGHT SCATTERING; MICELLE; MOLECULE; MORPHOLOGY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SERUM; SYNTHESIS; TEMPERATURE; TRANSMISSION ELECTRON MICROSCOPY;

ACRYLAMIDES; ACRYLIC RESINS; ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; COATED MATERIALS, BIOCOMPATIBLE; DELAYED-ACTION PREPARATIONS; DIFFUSION; DOXORUBICIN; LACTIC ACID; MATERIALS TESTING; MICE; MICELLES; POLYGLYCOLIC ACID; POLYMERS;

EID: 14844341106     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2005.01.030     Document Type: Article

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