Adriamycin loaded pullulan acetate/sulfonamide conjugate nanoparticles responding to tumor pH: pH-dependent cell interaction, internalization and cytotoxicity in vitro

Journal of Controlled Release

Volumn 87, Issue 1-3, 2003, Pages 3-13

  Na, Kun ^a   Lee, Eun Seong ^b   Bae, You Han ^a  

^a UNIVERSITY OF UTAH   (United States)

^b Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

Cytotoxicity; Extracellular tumor pH; Internalization; Pullulan acetate; Sulfonamide

Indexed keywords

ACETIC ACID DERIVATIVE; DOXORUBICIN; NANOPARTICLE; PULLULAN ACETATE; SULFONAMIDE; UNCLASSIFIED DRUG;

BIOLOGICAL MODEL; BREAST TUMOR; CELL CULTURE; CELL INTERACTION; CELL LINE; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; CONFOCAL LASER MICROSCOPY; CONJUGATE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; IONIZATION; PH; PRIORITY JOURNAL; SURFACE PROPERTY; TUMOR CELL;

EID: 0037459003     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00345-0     Document Type: Conference Paper

References (21)

1. Matsumura Y., Maeda H. A new concept for macromolecular therapeutic in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46:1986;6387-6392.
2. Yasugi K., Nagasaki Y., Kato M., Kataoka K. Preparation and characterization of polymer micelles from poly(ethylene glycol)-poly(D,L-lactide) block copolymers as potential drug carrier. J. Controlled Release. 62:1999;89-100.
3. Nishikawa T., Akiyoshi K., Sunamoto J. Macromolecular complexation between bovine serum albumin and self-aggregated hydrogel nanoparticle of hydrophobized polysaccharide. J. Am. Chem. Soc. 118:1996;6110-6115.
4. Weinstein J.M., Leserman L.D. Liposome as drug carriers in cancer chemotherapy. Pharmacol. Ther. 24:1984;207-233.
5. Gref R., Minamitake Y., Peracchia M.T., Trubetskoy V., Torchilin V., Langer R. Biodegradable long-circulating polymeric nanospheres. Science. 263:1994;1600-1603.
6. Peracchia M.T., Gref R., Minamitake Y., Domb A., Loah N., Langer R. PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics. J. Controlled Release. 46:1997;223-231.
7. Maeda H., Wu J., Sawa T., Matsumura Y., Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J. Controlled Release. 65:2000;271-284.
8. Drummond D.C., Meyer O., Hong K., Kirpotin D.B., Papahadjopoulos D. Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. Pharmacol. Rev. 51:1999;691-743.
9. Chung J.E., Yokoyama M., Okano T. Inner core segment design for delivery control of thermo-responsive polymeric micelles. J. Controlled Release. 65:2000;93-103.
10. Chung J.E., Yokoyama M., Yamato M., Aoyagi T., Sakurai Y., Okano T. Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate). J. Controlled Release. 62:1999;115-127.
11. Yokoyama M., Okano T. Targetable drug carriers: present status and a future perspective. Adv. Drug Deliv. Rev. 21:1996;77-80.
12. Tannock I.F., Rotin D. Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res. 49:1989;4373-4384.
13. Stubbs M., McSheehy P.M.J., Griffiths J.R., Bashford C.L. Causes and consequences of tumor acidity and implications for treatment. Mol. Med. Today. 6:2000;15-19.
14. Park S.Y., Bae Y.H. Novel pH-sensitive polymers containing sulfonamide groups. Macromol. Rapid Commun. 20:1999;269-273.
15. Kang S.I., Bae Y.H. pH-Induced volume-phase transition by reversible crystal formation. Macromolecules. 34:2001;8173-8178.
16. Kang S.I., Na K., Bae Y.H. Sulfonamide containing polymers: A new class of pH-sensitive polymers and gels. Macromol. Symp. 172:2001;149-156.
17. Kang S.I., Bae Y.H. pH-Induced solubility transition of sulfonamide based polymers. J. Controlled Release. 80:2002;145-155.
18. Na K., Bae Y.H. Self-assembled hydrogel nanoparticles responsive to tumor extracellular pH from pullulan derivative/sulfonamide conjugate: Characterization, aggregation and adriamycin release in vitro. Pharmacol. Res. 19:2002;681-687.
19. Meschini S., Molinari A., Calcabrini A., Citro G., Arancia G. Intracellular localization of the antitumour drug adriamycin in living cultured cells: a conforcal microscopy study. J. Microsc. 176:1994;204-210.
20. Skalko N., Peschka R., Altenschmid U., Lung A., Schubert R. pH-sensitive liposomes for receptor-mediated delivery to chicken hepatoma (LMH) cells. FEBS Lett. 434:1998;351-356.
21. Lai B.-T., Gao J.-P., Lanks K.W. Mechanism of action and spectrum of cell lines sensitive to a doxorubicin-transferrin conjugate. Cancer Chemother. Pharmacol. 41:1998;155-160.