A novel tumor-targeted delivery system with hydrophobized hyaluronic acid-spermine conjugates (HHSCs) for efficient receptor-mediated siRNA delivery

International Journal of Pharmaceutics

Volumn 414, Issue 1-2, 2011, Pages 233-243

  Shen, Yan ^a   Wang, Buhai ^b   Lu, Yang ^c   Ouahab, Ammar ^a   Li, Qian ^a   Tu, Jiasheng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NORTHERN JIANGSU PEOPLE S HOSPITAL   (China)

^c BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

HA receptor; HA receptor mediated endocytosis; Hyaluronic acid; Small interfering RNA; Tumor targeted

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYCLOOXYGENASE 2; FLUORESCEIN ISOTHIOCYANATE; HEPARIN; HERMES ANTIGEN; HYALURONIC ACID; LIPOFECTAMINE; NUCLEASE; RECEPTOR; SMALL INTERFERING RNA; SPERMINE;

ARTICLE; CAVEOLA; COMPLEX FORMATION; CONJUGATE; CONTROLLED STUDY; DEGRADATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROPHOBICITY; LYSOSOME; MICELLE; PRIORITY JOURNAL;

ANTIGENS, CD44; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ENDOCYTOSIS; GENE SILENCING; GENE THERAPY; HUMANS; HYALURONIC ACID; INHIBITORY CONCENTRATION 50; MOLECULAR TARGETED THERAPY; NEOPLASMS; RNA, SMALL INTERFERING; SPERMINE; TRANSFECTION;

EID: 79959742514     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.04.049     Document Type: Article

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