-
1
-
-
0031027349
-
"In vivo studies with antisense oligonucleotides"
-
Akhtar, S. and Agrawal, S. (1997) "In vivo studies with antisense oligonucleotides", Trends Pharmacol. Sci. 18, 12-18.
-
(1997)
Trends Pharmacol. Sci.
, vol.18
, pp. 12-18
-
-
Akhtar, S.1
Agrawal, S.2
-
2
-
-
0026002671
-
"Stability of antisense DNA oligodeoxynucleotide analogs in cellular extracts and sera"
-
Akhtar, S., Kole, R. and Juliano, R.L. (1991) "Stability of antisense DNA oligodeoxynucleotide analogs in cellular extracts and sera", Life Sci. 49, 1793-1801.
-
(1991)
Life Sci.
, vol.49
, pp. 1793-1801
-
-
Akhtar, S.1
Kole, R.2
Juliano, R.L.3
-
3
-
-
0034739601
-
"The delivery of antisense therapeutics"
-
Akhtar, S., Hughes, M.D., Khan, A., Double, J., Hussain, M., Nawaz, Q., Bibby, M. and Sayyed, P. (2000) "The delivery of antisense therapeutics", Adv. Drug Deliv. Rev. 44, 3-21.
-
(2000)
Adv. Drug Deliv. Rev.
, vol.44
, pp. 3-21
-
-
Akhtar, S.1
Hughes, M.D.2
Khan, A.3
Double, J.4
Hussain, M.5
Nawaz, Q.6
Bibby, M.7
Sayyed, P.8
-
4
-
-
1642273831
-
"An algorithm for selection of functional siRNA sequences"
-
Amarzguioui, M. and Prydz, H. (2004) "An algorithm for selection of functional siRNA sequences", Biochem. Biophys. Res. Commun. 316, 1050-1058.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.316
, pp. 1050-1058
-
-
Amarzguioui, M.1
Prydz, H.2
-
5
-
-
0037440005
-
"Tolerance for mutations and chemical modifications in a siRNA"
-
Amarzguioui, M., Holen, T., Babaie, E. and Prydz, H. (2003) "Tolerance for mutations and chemical modifications in a siRNA" , Nucleic Acids Res. 31, 589-595.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 589-595
-
-
Amarzguioui, M.1
Holen, T.2
Babaie, E.3
Prydz, H.4
-
6
-
-
0036844766
-
"In vivo characteristics of cationic liposomes as delivery vectors for gene therapy"
-
Audouy, S.A., de Leij, L.F., Hoekstra, D. and Molema, G. (2002) "In vivo characteristics of cationic liposomes as delivery vectors for gene therapy", Pharm. Res. 19, 1599-1605.
-
(2002)
Pharm. Res.
, vol.19
, pp. 1599-1605
-
-
Audouy, S.A.1
de Leij, L.F.2
Hoekstra, D.3
Molema, G.4
-
7
-
-
0035930615
-
"Biosynthesis of the linkage region of glycosaminoglycans: Cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6)"
-
Bai, X., Zhou, D., Brown, J.R., Crawford, B.E., Hennet, T. and Esko, J.D. (2001) "Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6)", J. Biol. Chem. 276, 48189-48195.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 48189-48195
-
-
Bai, X.1
Zhou, D.2
Brown, J.R.3
Crawford, B.E.4
Hennet, T.5
Esko, J.D.6
-
8
-
-
0347444723
-
"MicroRNAs: Genomics, biogenesis, mechanism, and function"
-
Bartel, D.P. (2004) "MicroRNAs: genomics, biogenesis, mechanism, and function", Cell 116, 281-297.
-
(2004)
Cell
, vol.116
, pp. 281-297
-
-
Bartel, D.P.1
-
9
-
-
0035942783
-
"RNA interference. The short answer"
-
Bass, B.L. (2001) "RNA interference. The short answer", Nature 411, 428-429.
-
(2001)
Nature
, vol.411
, pp. 428-429
-
-
Bass, B.L.1
-
10
-
-
1842588051
-
"Gene silencing nucleic acids designed by scanning arrays: Anti-EGFR activity of siRNA, ribozyme and DNA enzymes targeting a single hybridization-accessible region using the same delivery system"
-
Beale, G., Hollins, A.J., Benboubetra, M., Sohail, M., Fox, S.P., Benter, I. and Akhtar, S. (2003) "Gene silencing nucleic acids designed by scanning arrays: anti-EGFR activity of siRNA, ribozyme and DNA enzymes targeting a single hybridization-accessible region using the same delivery system", J. Drug Target. 11, 449-456.
-
(2003)
J. Drug Target.
, vol.11
, pp. 449-456
-
-
Beale, G.1
Hollins, A.J.2
Benboubetra, M.3
Sohail, M.4
Fox, S.P.5
Benter, I.6
Akhtar, S.7
-
11
-
-
84957608064
-
"Basics of siRNA design and chemical synthesis"
-
Sohail, M., ed., (CRC press, Florida, USA)
-
Boese, Q., Reynolds, A. and Marshall, W.A. (2004) "Basics of siRNA design and chemical synthesis", In: Sohail, M., ed., Gene Silencing by RNA Interference: Technology and Application (CRC press, Florida, USA), pp 15-35.
-
(2004)
Gene Silencing By RNA Interference: Technology and Application
, pp. 15-35
-
-
Boese, Q.1
Reynolds, A.2
Marshall, W.A.3
-
12
-
-
0038521255
-
"The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript"
-
Bohula, E.A., Salisbury, A.J., Sohail, M., Playford, M.P., Riedemann, J., Southern, E.M. and Macaulay, V.M. (2003) "The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript", J. Biol. Chem. 278, 15991-15997.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 15991-15997
-
-
Bohula, E.A.1
Salisbury, A.J.2
Sohail, M.3
Playford, M.P.4
Riedemann, J.5
Southern, E.M.6
Macaulay, V.M.7
-
13
-
-
0037180775
-
"Glucose transporter recycling in response to insulin is facilitated by myosin Myolc"
-
Bose, A., Guilherme, A., Robida, S.I., Nicoloro, S.M., Zhou, Q.L., Jiang, Z.Y., Pomerleau, D.P. and Czech, M.P. (2002) "Glucose transporter recycling in response to insulin is facilitated by myosin Myolc", Nature 420, 821-824.
-
(2002)
Nature
, vol.420
, pp. 821-824
-
-
Bose, A.1
Guilherme, A.2
Robida, S.I.3
Nicoloro, S.M.4
Zhou, Q.L.5
Jiang, Z.Y.6
Pomerleau, D.P.7
Czech, M.P.8
-
14
-
-
0029160083
-
"A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine"
-
Boussif, O., Lezoualc'h, F., Zanta, M.A., Mergny, M.D., Scherman, D., Demeneix, B. and Behr, J.P. (1995) "A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine", Proc. Natl Acad. Sci. USA 92, 7297-7301.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 7297-7301
-
-
Boussif, O.1
Lezoualc'h, F.2
Zanta, M.A.3
Mergny, M.D.4
Scherman, D.5
Demeneix, B.6
Behr, J.P.7
-
15
-
-
0035113736
-
"Locked nucleic acid (LNA): Fine-tuning the recognition of DNA and RNA"
-
Braasch, D.A. and Corey, D.R. (2001) "Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA", Chem. Biol. 8, 1-7.
-
(2001)
Chem. Biol.
, vol.8
, pp. 1-7
-
-
Braasch, D.A.1
Corey, D.R.2
-
16
-
-
0038385504
-
"RNA interference in mammalian cells by chemically-modified RNA"
-
Braasch, D.A., Jensen, S., Liu, Y., Kaur, K., Arar, K., White, M.A. and Corey, D.R. (2003) "RNA interference in mammalian cells by chemically-modified RNA", Biochemistry 42, 7967-7975.
-
(2003)
Biochemistry
, vol.42
, pp. 7967-7975
-
-
Braasch, D.A.1
Jensen, S.2
Liu, Y.3
Kaur, K.4
Arar, K.5
White, M.A.6
Corey, D.R.7
-
17
-
-
1242316928
-
"Biodistribution of phosphodiester and phosphorothioate siRNA"
-
Braasch, D.A., Paroo, Z., Constantinescu, A., Ren, G., Oz, O.K., Mason, R.P. and Corey, D.R. (2004) "Biodistribution of phosphodiester and phosphorothioate siRNA", Bioorg. Med. Chem. Lett. 14, 1139-1143.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 1139-1143
-
-
Braasch, D.A.1
Paroo, Z.2
Constantinescu, A.3
Ren, G.4
Oz, O.K.5
Mason, R.P.6
Corey, D.R.7
-
18
-
-
0038419800
-
"Induction of an interferon response by RNAi vectors in mammalian cells"
-
Bridge, A.J., Pebernard, S., Ducraux, A., Nicoulaz, A.L. and Iggo, R. (2003) "Induction of an interferon response by RNAi vectors in mammalian cells", Nat. Genet. 34, 263-264.
-
(2003)
Nat. Genet.
, vol.34
, pp. 263-264
-
-
Bridge, A.J.1
Pebernard, S.2
Ducraux, A.3
Nicoulaz, A.L.4
Iggo, R.5
-
19
-
-
0036467758
-
"A new approach to the inhibition of gene expression"
-
Caplen, N.J. (2002) "A new approach to the inhibition of gene expression", Trends Biotechnol. 20, 49-51.
-
(2002)
Trends Biotechnol.
, vol.20
, pp. 49-51
-
-
Caplen, N.J.1
-
20
-
-
0036839458
-
"Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference"
-
Capodici, J., Kariko, K. and Weissman, D. (2002) "Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference", J. Immunol. 169, 5196-5201.
-
(2002)
J. Immunol.
, vol.169
, pp. 5196-5201
-
-
Capodici, J.1
Kariko, K.2
Weissman, D.3
-
21
-
-
0036792769
-
"Fragile X-related protein and VIG associate with the RNA interference machinery"
-
Caudy, A.A., Myers, M., Hannon, G.J. and Hammond, S.M. (2002) "Fragile X-related protein and VIG associate with the RNA interference machinery", Genes Dev. 16, 2491-2496.
-
(2002)
Genes Dev.
, vol.16
, pp. 2491-2496
-
-
Caudy, A.A.1
Myers, M.2
Hannon, G.J.3
Hammond, S.M.4
-
22
-
-
0141843655
-
"A micrococcal nuclease homologue in RNAi effector complexes"
-
Caudy, A.A., Ketting, R.F., Hammond, S.M., Denli, A.M., Bathoorn, A.M., Tops, B.B., Silva, J.M., Myers, M.M., Hannon, G.J. and Plasterk, R.H. (2003) "A micrococcal nuclease homologue in RNAi effector complexes", Nature 425, 411-414.
-
(2003)
Nature
, vol.425
, pp. 411-414
-
-
Caudy, A.A.1
Ketting, R.F.2
Hammond, S.M.3
Denli, A.M.4
Bathoorn, A.M.5
Tops, B.B.6
Silva, J.M.7
Myers, M.M.8
Hannon, G.J.9
Plasterk, R.H.10
-
23
-
-
0038798081
-
"Genomewide view of gene silencing by small interfering RNAs"
-
Chi, J.T., Chang, H.Y., Wang, N.N., Chang, D.S., Dunphy, N. and Brown, P.O. (2003) "Genomewide view of gene silencing by small interfering RNAs", Proc. Natl Acad. Sci. USA 100, 6343-6346.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 6343-6346
-
-
Chi, J.T.1
Chang, H.Y.2
Wang, N.N.3
Chang, D.S.4
Dunphy, N.5
Brown, P.O.6
-
24
-
-
0036752785
-
"RNAi in human cells: Basic structural and functional features of small interfering RNA"
-
Chiu, Y.L. and Rana, T.M. (2002) "RNAi in human cells: basic structural and functional features of small interfering RNA", Mol. Cell 10, 549-561.
-
(2002)
Mol. Cell
, vol.10
, pp. 549-561
-
-
Chiu, Y.L.1
Rana, T.M.2
-
25
-
-
0041331496
-
"siRNA function in RNAi: A chemical modification analysis"
-
Chiu, Y.L. and Rana, T.M. (2003) "siRNA function in RNAi: a chemical modification analysis", RNA 9, 1034-1048.
-
(2003)
RNA
, vol.9
, pp. 1034-1048
-
-
Chiu, Y.L.1
Rana, T.M.2
-
26
-
-
0041845266
-
"CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle"
-
Chung, H.K., Yi, Y.W., Jung, N.C., Kim, D., Suh, J.M., Kim, H., Park, K.C., Song, J.H., Kim, D.W., Hwang, E.S., Yoon, S.H., Bae, Y.S., Kim, J.M., Bae, I. and Shong, M. (2003) "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle", J. Biol. Chem. 278, 28079-28088.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 28079-28088
-
-
Chung, H.K.1
Yi, Y.W.2
Jung, N.C.3
Kim, D.4
Suh, J.M.5
Kim, H.6
Park, K.C.7
Song, J.H.8
Kim, D.W.9
Hwang, E.S.10
Yoon, S.H.11
Bae, Y.S.12
Kim, J.M.13
Bae, I.14
Shong, M.15
-
27
-
-
0029812567
-
"A nonantisense sequence-selective effect of a phosphorothioate oligodeoxynucleotide directed against the epidermal growth factor receptor in A431 cells"
-
Coulson, J.M., Poyner, D.R., Chantry, A., Irwin, W.J. and Akhtar, S. (1996) "A nonantisense sequence-selective effect of a phosphorothioate oligodeoxynucleotide directed against the epidermal growth factor receptor in A431 cells", Mol. Pharmacol. 50, 314-325.
-
(1996)
Mol. Pharmacol.
, vol.50
, pp. 314-325
-
-
Coulson, J.M.1
Poyner, D.R.2
Chantry, A.3
Irwin, W.J.4
Akhtar, S.5
-
28
-
-
0038606999
-
"Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells"
-
Czauderna, F., Fechtner, M., Dames, S., Aygun, H., Klippel, A., Pronk, G.J., Giese, K. and Kaufmann, J. (2003) "Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells", Nucleic Acids Res. 31, 2705-2716.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 2705-2716
-
-
Czauderna, F.1
Fechtner, M.2
Dames, S.3
Aygun, H.4
Klippel, A.5
Pronk, G.J.6
Giese, K.7
Kaufmann, J.8
-
29
-
-
0037249141
-
"Modified microplex vector enhances transfection of cells in culture while maintaining tumour-selective gene delivery in-vivo"
-
Dass, C.R. and Burton, M.A. (2003) "Modified microplex vector enhances transfection of cells in culture while maintaining tumour-selective gene delivery in-vivo", J. Pharm. Pharmacol. 55, 19-25.
-
(2003)
J. Pharm. Pharmacol.
, vol.55
, pp. 19-25
-
-
Dass, C.R.1
Burton, M.A.2
-
30
-
-
0012756249
-
"RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase"
-
Donze, O. and Picard, D. (2002) "RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase", Nucleic Acids Res. 30, e46.
-
(2002)
Nucleic Acids Res.
, vol.30
-
-
Donze, O.1
Picard, D.2
-
31
-
-
10344261343
-
"siRNA relieves chronic neuropathic
-
Dorn, G., Patel, S., Wotherspoon, G., Hemmings-Mieszczak, M., Barclay, J., Natt, F.J., Martin, P., Bevan, S., Fox, A., Ganju, P., Wish M.W. and Hall, J. (2004) "siRNA relieves chronic neuropathic pain", Nucleic Acids Res. 32, e49.
-
(2004)
Pain" Nucleic Acids Res.
, vol.32
-
-
Dorn, G.1
Patel, S.2
Wotherspoon, G.3
Hemmings-Mieszczak, M.4
Barclay, J.5
Natt, F.J.6
Martin, P.7
Bevan, S.8
Fox, A.9
Ganju, P.10
Wish, M.W.11
Hall, J.12
-
32
-
-
3242677639
-
"siRNAs: Applications in functional genomics and potential as therapeutics"
-
Dorsett, Y. and Tuschl, T. (2004) "siRNAs: applications in functional genomics and potential as therapeutics", Nat. Rev. Drug Discov. 3, 318-329.
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 318-329
-
-
Dorsett, Y.1
Tuschl, T.2
-
33
-
-
0042232110
-
"Studies on the internalization mechanism of cationic cell-penetrating peptides"
-
Drin, G., Cottin, S., Blanc, E., Rees, A.R. and Temsamani, J. (2003) "Studies on the internalization mechanism of cationic cell-penetrating peptides", J. Biol. Chem. 278, 31192-31201.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 31192-31201
-
-
Drin, G.1
Cottin, S.2
Blanc, E.3
Rees, A.R.4
Temsamani, J.5
-
34
-
-
0242493171
-
"RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity"
-
Duxbury, M.S., Ito, H., Benoit, E., Zinner, M.J., Ashley, S.W. and Whang, E.E. (2003) "RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity", Biochem. Biophys. Res. Commun. 311, 786-792.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.311
, pp. 786-792
-
-
Duxbury, M.S.1
Ito, H.2
Benoit, E.3
Zinner, M.J.4
Ashley, S.W.5
Whang, E.E.6
-
35
-
-
0037686295
-
"Killing the messenger: Short RNAs that silence gene expression"
-
Dykxhoorn, D.M., Novina, C.D. and Sharp, P.A. (2003) "Killing the messenger: short RNAs that silence gene expression", Nat. Rev. Mol. Cell Biol. 4, 457-467.
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 457-467
-
-
Dykxhoorn, D.M.1
Novina, C.D.2
Sharp, P.A.3
-
36
-
-
0035942736
-
"Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells"
-
Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K. and Tuschl, T. (2001a) "Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells", Nature 411, 494-498.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
37
-
-
0035863097
-
"RNA interference is mediated by 21- and 22-nucleotide RNAs"
-
Elbashir, S.M., Lendeckel, W. and Tuschl, T. (2001b) "RNA interference is mediated by 21- and 22-nucleotide RNAs", Genes Dev. 15, 188-200.
-
(2001)
Genes Dev.
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
38
-
-
0035803583
-
"Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate"
-
Elbashir, S.M., Martinez, J., Patkaniowska, A., Lendeckel, W. and Tuschl, T. (2001c) "Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate", EMBO J. 20, 6877-6888.
-
(2001)
EMBO J.
, vol.20
, pp. 6877-6888
-
-
Elbashir, S.M.1
Martinez, J.2
Patkaniowska, A.3
Lendeckel, W.4
Tuschl, T.5
-
39
-
-
0036351317
-
"Analysis of gene function in somatic mammalian cells using small interfering RNAs"
-
Elbashir, S.M., Harborth, J., Weber, K. and Tuschl, T. (2002) "Analysis of gene function in somatic mammalian cells using small interfering RNAs", Methods 26, 199-213.
-
(2002)
Methods
, vol.26
, pp. 199-213
-
-
Elbashir, S.M.1
Harborth, J.2
Weber, K.3
Tuschl, T.4
-
40
-
-
0026497428
-
"Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity"
-
Farhood, H., Bottega, R., Epand, R.M. and Huang, L. (1992) "Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity", Biochim. Biophys. Acta 1111, 239-246.
-
(1992)
Biochim. Biophys. Acta
, vol.1111
, pp. 239-246
-
-
Farhood, H.1
Bottega, R.2
Epand, R.M.3
Huang, L.4
-
41
-
-
0028054797
-
"Tat-mediated delivery of heterologous proteins into cells"
-
Fawell, S., Seery, J., Daikh, Y., Moore, C., Chen, L.L., Pepinsky, B. and Barsoum, J. (1994) "Tat-mediated delivery of heterologous proteins into cells", Proc. Natl Acad. Sci. USA 91, 664-668.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 664-668
-
-
Fawell, S.1
Seery, J.2
Daikh, Y.3
Moore, C.4
Chen, L.L.5
Pepinsky, B.6
Barsoum, J.7
-
42
-
-
0030844046
-
"Cellular uptake properties of a 2′-amino/2′-O-methyl-modified chimeric hammerhead ribozyme targeted to the epidermal growth factor receptor mRNA"
-
Fell, P.L., Hudson, A.J., Reynolds, M.A., Usman, N. and Akhtar, S. (1997) "Cellular uptake properties of a 2′-amino/2′-O-methyl-modified chimeric hammerhead ribozyme targeted to the epidermal growth factor receptor mRNA", Antisense Nucleic Acid Drug Dev. 7, 319-326.
-
(1997)
Antisense Nucleic Acid Drug Dev.
, vol.7
, pp. 319-326
-
-
Fell, P.L.1
Hudson, A.J.2
Reynolds, M.A.3
Usman, N.4
Akhtar, S.5
-
43
-
-
0030670810
-
"Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells"
-
Filion, M.C. and Phillips, N.C. (1997) "Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells", Biochim. Biophys. Acta 1329, 345-356.
-
(1997)
Biochim. Biophys. Acta
, vol.1329
, pp. 345-356
-
-
Filion, M.C.1
Phillips, N.C.2
-
44
-
-
0042173218
-
"SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth"
-
Filleur, S., Courtin, A., Ait-Si-Ali, S., Guglielmi, J., Merle, C., Harel-Bellan, A., Clezardin, P. and Cabon, F. (2003) "SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth", Cancer Res. 63, 3919-3922.
-
(2003)
Cancer Res.
, vol.63
, pp. 3919-3922
-
-
Filleur, S.1
Courtin, A.2
Ait-Si-Ali, S.3
Guglielmi, J.4
Merle, C.5
Harel-Bellan, A.6
Clezardin, P.7
Cabon, F.8
-
45
-
-
0032545933
-
"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans"
-
Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E. and Mello, C.C. (1998) "Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans", Nature 391, 806-811.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
46
-
-
0141446039
-
"Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins"
-
Fittipaldi, A., Ferrari, A., Zoppe, M., Arcangeli, C., Pellegrini, V., Beltram, F. and Giacca, M. (2003) "Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins", J. Biol. Chem. 278, 34141-34149.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34141-34149
-
-
Fittipaldi, A.1
Ferrari, A.2
Zoppe, M.3
Arcangeli, C.4
Pellegrini, V.5
Beltram, F.6
Giacca, M.7
-
47
-
-
0345708273
-
"CD46 is a cellular receptor for group B adenoviruses"
-
Gaggar, A., Shayakhmetov, D.M. and Lieber, A. (2003) "CD46 is a cellular receptor for group B adenoviruses", Nat. Med. 9, 1408-1412.
-
(2003)
Nat. Med.
, vol.9
, pp. 1408-1412
-
-
Gaggar, A.1
Shayakhmetov, D.M.2
Lieber, A.3
-
48
-
-
0037114679
-
"Specific interference with gene expression and gene function mediated by long dsRNA in neural cells"
-
Gan, L., Anton, K.E., Masterson, B.A., Vincent, V.A., Ye, S. and Gonzalez-Zulueta, M. (2002) "Specific interference with gene expression and gene function mediated by long dsRNA in neural cells" , J. Neurosci. Methods 121, 151-157.
-
(2002)
J. Neurosci. Methods
, vol.121
, pp. 151-157
-
-
Gan, L.1
Anton, K.E.2
Masterson, B.A.3
Vincent, V.A.4
Ye, S.5
Gonzalez-Zulueta, M.6
-
49
-
-
0035043324
-
"Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides"
-
Geary, R.S., Yu, R.Z. and Levin, A.A. (2001) "Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides", Curr. Opin. Investig. Drugs 2, 562-573.
-
(2001)
Curr. Opin. Investig. Drugs
, vol.2
, pp. 562-573
-
-
Geary, R.S.1
Yu, R.Z.2
Levin, A.A.3
-
50
-
-
0346873025
-
"Small interfering RNA inhibits hepatitis B virus replication in mice"
-
Giladi, H., Ketzinel-Gilad, M., Rivkin, L., Felig, Y., Nussbaum, O. and Galun, E. (2003) "Small interfering RNA inhibits hepatitis B virus replication in mice", Mol. Ther 8, 769-776.
-
(2003)
Mol. Ther.
, vol.8
, pp. 769-776
-
-
Giladi, H.1
Ketzinel-Gilad, M.2
Rivkin, L.3
Felig, Y.4
Nussbaum, O.5
Galun, E.6
-
51
-
-
0027655718
-
"Polyamidoamine cascade polymers mediate efficient transfection of cells in culture"
-
Haensler, J. and Szoka, F.C., Jr. (1993) "Polyamidoamine cascade polymers mediate efficient transfection of cells in culture" , Bioconjug. Chem. 4, 372-379.
-
(1993)
Bioconjug. Chem.
, vol.4
, pp. 372-379
-
-
Haensler, J.1
Szoka Jr., F.C.2
-
52
-
-
3042762351
-
"Unravelling the general properties of siRNAs strength in numbers and lessons from the past"
-
Hall, J. (2004) "Unravelling the general properties of siRNAs strength in numbers and lessons from the past", Nat. Rev. Genet. 5, 552-557.
-
(2004)
Nat. Rev. Genet.
, vol.5
, pp. 552-557
-
-
Hall, J.1
-
53
-
-
0034673638
-
"An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells"
-
Hammond, S.M., Bernstein, E., Beach, D. and Hannon, G.J. (2000) "An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells", Nature 404, 293-296.
-
(2000)
Nature
, vol.404
, pp. 293-296
-
-
Hammond, S.M.1
Bernstein, E.2
Beach, D.3
Hannon, G.J.4
-
54
-
-
0035839109
-
"Argonaute2, a link between genetic and biochemical analyses of RNAi"
-
Hammond, S.M., Boettcher, S., Candy, A.A., Kobayashi, R. and Hannon, G.J. (2001) "Argonaute2, a link between genetic and biochemical analyses of RNAi", Science 293, 1146-1150.
-
(2001)
Science
, vol.293
, pp. 1146-1150
-
-
Hammond, S.M.1
Boettcher, S.2
Candy, A.A.3
Kobayashi, R.4
Hannon, G.J.5
-
55
-
-
24344500241
-
"Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing"
-
Harborth, J., Elbashir, S.M., Vandenburgh, K., Manninga, H., Scaringe, S.A., Weber, K. and Tuschl, T. (2003) "Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing", Antisense Nucleic Acid Drug Dev. 13, 83-105.
-
(2003)
Antisense Nucleic Acid Drug Dev.
, vol.13
, pp. 83-105
-
-
Harborth, J.1
Elbashir, S.M.2
Vandenburgh, K.3
Manninga, H.4
Scaringe, S.A.5
Weber, K.6
Tuschl, T.7
-
56
-
-
0037134623
-
"RNA interference (RNA(i)) induction with various types of synthetic oligonucleotide duplexes in cultured human cells"
-
Hohjoh, H. (2002) "RNA interference (RNA(i)) induction with various types of synthetic oligonucleotide duplexes in cultured human cells", FEBS Lett. 521, 195-199.
-
(2002)
FEBS Lett.
, vol.521
, pp. 195-199
-
-
Hohjoh, H.1
-
57
-
-
0037089135
-
"Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor"
-
Holen, T., Amarzguioui, M., Wiiger, M.T., Babaie, E. and Prydz, H. (2002) "Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor", Nucleic Acids Res. 30, 1757-1766.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 1757-1766
-
-
Holen, T.1
Amarzguioui, M.2
Wiiger, M.T.3
Babaie, E.4
Prydz, H.5
-
58
-
-
1542511346
-
"Evaluation of generation 2 and 3 poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor"
-
Hollins, A.J., Benboubetra, M., Omidi, Y., Zinselmeyer, B.H., Schatzlein, A.G., Uchegbu, I.F. and Akhtar, S. (2004) "Evaluation of generation 2 and 3 poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor", Pharm. Res. 21, 458-466.
-
(2004)
Pharm. Res.
, vol.21
, pp. 458-466
-
-
Hollins, A.J.1
Benboubetra, M.2
Omidi, Y.3
Zinselmeyer, B.H.4
Schatzlein, A.G.5
Uchegbu, I.F.6
Akhtar, S.7
-
59
-
-
0037428508
-
"Erbin suppresses the MAP kinase pathway"
-
Huang, Y.Z., Zang, M., Xiong, W.C., Luo, Z. and Mei, L. (2003) "Erbin suppresses the MAP kinase pathway", J. Biol. Chem. 278, 1108-1114.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 1108-1114
-
-
Huang, Y.Z.1
Zang, M.2
Xiong, W.C.3
Luo, Z.4
Mei, L.5
-
60
-
-
1842538716
-
"Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells"
-
Huang, H., Zegarra-Moro, O.L., Benson, D. and Tindall, D.J. (2004) "Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells", Oncogene 23, 2161-2176.
-
(2004)
Oncogene
, vol.23
, pp. 2161-2176
-
-
Huang, H.1
Zegarra-Moro, O.L.2
Benson, D.3
Tindall, D.J.4
-
61
-
-
0032945789
-
"Cellular delivery of hammerhead ribozymes conjugated to a transferrin receptor antibody"
-
Hudson, A.J., Normand, N., Ackroyd, J. and Akhtar, S. (1999) "Cellular delivery of hammerhead ribozymes conjugated to a transferrin receptor antibody", Int. J. Pharm. 182, 49-58.
-
(1999)
Int. J. Pharm.
, vol.182
, pp. 49-58
-
-
Hudson, A.J.1
Normand, N.2
Ackroyd, J.3
Akhtar, S.4
-
62
-
-
0033990408
-
"In vitro transport and delivery of antisense oligonucleotides"
-
Hughes, J., Astriab, A., Yoo, H., Alahari, S., Liang, E., Sergueev, D., Shaw, B.R. and Juliano, R.L. (2000) "In vitro transport and delivery of antisense oligonucleotides", Methods Enzymol. 313, 342-358.
-
(2000)
Methods Enzymol.
, vol.313
, pp. 342-358
-
-
Hughes, J.1
Astriab, A.2
Yoo, H.3
Alahari, S.4
Liang, E.5
Sergueev, D.6
Shaw, B.R.7
Juliano, R.L.8
-
63
-
-
0035282789
-
"Cellular delivery of antisense oligonucleotides and ribozymes"
-
Hughes, M.D., Hussain, M., Nawaz, Q., Petch, A.K., Sayyed, P. and Akhtar, S. (2001) "Cellular delivery of antisense oligonucleotides and ribozymes", Drug Discov. Today 6, 303-315.
-
(2001)
Drug Discov. Today
, vol.6
, pp. 303-315
-
-
Hughes, M.D.1
Hussain, M.2
Nawaz, Q.3
Petch, A.K.4
Sayyed, P.5
Akhtar, S.6
-
64
-
-
0036791671
-
"A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins"
-
Ishizuka, A., Siomi, M.C. and Siomi, H. (2002) "A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins", Genes Dev. 16, 2497-2508.
-
(2002)
Genes Dev.
, vol.16
, pp. 2497-2508
-
-
Ishizuka, A.1
Siomi, M.C.2
Siomi, H.3
-
65
-
-
0034057326
-
"Studies on uptake, sub-cellular trafficking and efflux of antisense oligodeoxynucleotides in glioma cells using self-assembling cationic lipoplexes as delivery systems"
-
Islam, A., Handley, S.L., Thompson, K.S. and Akhtar, S. (2000) "Studies on uptake, sub-cellular trafficking and efflux of antisense oligodeoxynucleotides in glioma cells using self-assembling cationic lipoplexes as delivery systems", J. Drug Target. 7, 373-382.
-
(2000)
J. Drug Target.
, vol.7
, pp. 373-382
-
-
Islam, A.1
Handley, S.L.2
Thompson, K.S.3
Akhtar, S.4
-
66
-
-
0037685280
-
"Expression profiling reveals off-target gene regulation by RNAi"
-
Jackson, A.L., Bartz, S.R., Schelter, J., Kobayashi, S.V., Burchard, J., Mao, M., Li, B., Cavet, G. and Linsley, P.S. (2003) "Expression profiling reveals off-target gene regulation by RNAi", Nat. Biotechnol. 21, 635-637.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
Bartz, S.R.2
Schelter, J.3
Kobayashi, S.V.4
Burchard, J.5
Mao, M.6
Li, B.7
Cavet, G.8
Linsley, P.S.9
-
67
-
-
0141537250
-
"Enhanced gene silencing by the application of multiple specific small interfering RNAs"
-
Ji, J., Wernli, M., Klimkait, T. and Erb, P. (2003) "Enhanced gene silencing by the application of multiple specific small interfering RNAs", FEBS Lett. 552, 247-252.
-
(2003)
FEBS Lett.
, vol.552
, pp. 247-252
-
-
Ji, J.1
Wernli, M.2
Klimkait, T.3
Erb, P.4
-
68
-
-
1842450468
-
"Design, syntheses and in vitro gene delivery efficacies of novel mono-, di- and trilysinated cationic lipids: A structure-activity investigation"
-
Karmali, P.P., Kumar, V.V. and Chaudhuri, A. (2004) "Design, syntheses and in vitro gene delivery efficacies of novel mono-, di- and trilysinated cationic lipids: a structure-activity investigation", J. Med. Chem. 47, 2123-2132.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 2123-2132
-
-
Karmali, P.P.1
Kumar, V.V.2
Chaudhuri, A.3
-
69
-
-
0027479864
-
"Uniformly modified 2′-deoxy-2′-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets"
-
Kawasaki, A.M., Casper, M.D., Freier, S.M., Lesnik, E.A., Zounes, M.C., Cummins, L.L., Gonzalez, C. and Cook, P.D. (1993) "Uniformly modified 2′-deoxy-2′-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets", J. Med. Chem. 36, 831-841.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 831-841
-
-
Kawasaki, A.M.1
Casper, M.D.2
Freier, S.M.3
Lesnik, E.A.4
Zounes, M.C.5
Cummins, L.L.6
Gonzalez, C.7
Cook, P.D.8
-
70
-
-
1342346710
-
"A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans"
-
Kennedy, S., Wang, D. and Ruvkun, G. (2004) "A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans", Nature 427, 645-649.
-
(2004)
Nature
, vol.427
, pp. 645-649
-
-
Kennedy, S.1
Wang, D.2
Ruvkun, G.3
-
71
-
-
0032443021
-
"Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway"
-
Kennerdell, J.R. and Carthew, R.W. (1998) "Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway", Cell 95, 1017-1026.
-
(1998)
Cell
, vol.95
, pp. 1017-1026
-
-
Kennerdell, J.R.1
Carthew, R.W.2
-
72
-
-
0034471699
-
"Site-specific administration of antisense oligonucleotides using biodegradable polymer microspheres provides sustained delivery and improved subcellular biodistribution in the neostriatum of the rat brain"
-
Khan, A., Sommer, W., Fuxe, K. and Akhtar, S. (2000) "Site-specific administration of antisense oligonucleotides using biodegradable polymer microspheres provides sustained delivery and improved subcellular biodistribution in the neostriatum of the rat brain", J. Drug Target. 8, 319-334.
-
(2000)
J. Drug Target.
, vol.8
, pp. 319-334
-
-
Khan, A.1
Sommer, W.2
Fuxe, K.3
Akhtar, S.4
-
73
-
-
4644293047
-
"Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: In vitro and in vivo studies"
-
in press
-
Khan, A., Benboubetra, M., Wooi, K.N., Fox, S., Beck, G. and Akhtar, S. (2004) "Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies", J. Drug Target., in press.
-
(2004)
J. Drug Target
-
-
Khan, A.1
Benboubetra, M.2
Wooi, K.N.3
Fox, S.4
Beck, G.5
Akhtar, S.6
-
74
-
-
0142165224
-
"Functional siRNAs and miRNAs exhibit strand bias"
-
Khvorova, A., Reynolds, A. and Jayasena, S.D. (2003) "Functional siRNAs and miRNAs exhibit strand bias", Cell 115, 209-216.
-
(2003)
Cell
, vol.115
, pp. 209-216
-
-
Khvorova, A.1
Reynolds, A.2
Jayasena, S.D.3
-
75
-
-
0042161890
-
"The activity of siRNA in mammalian cells is related to structural target accessibility: A comparison with antisense oligonucleotides"
-
Kretschmer-Kazemi Far, R. and Sczakiel, G. (2003) "The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides", Nucleic Acids Res. 31, 4417-4424.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 4417-4424
-
-
Kretschmer-Kazemi Far, R.1
Sczakiel, G.2
-
76
-
-
0037015041
-
"RNAi functions in cultured mammalian neurons"
-
Krichevsky, A.M. and Kosik, K.S. (2002) "RNAi functions in cultured mammalian neurons", Proc. Natl Acad. Sci. USA 99, 11926-11929.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 11926-11929
-
-
Krichevsky, A.M.1
Kosik, K.S.2
-
77
-
-
0142092529
-
"High-throughput selection of effective RNAi probes for gene silencing"
-
Kumar, R., Conklin, D.S. and Mittal, V. (2003) "High-throughput selection of effective RNAi probes for gene silencing", Genome Res. 13, 2333-2340.
-
(2003)
Genome Res.
, vol.13
, pp. 2333-2340
-
-
Kumar, R.1
Conklin, D.S.2
Mittal, V.3
-
78
-
-
0042674380
-
"Recapitulation of the cellular xeroderma pigmentosum-variant phenotypes using short interfering RNA for DNA polymerase H"
-
Laposa, R.R., Feeney, L. and Cleaver, J.E. (2003) "Recapitulation of the cellular xeroderma pigmentosum-variant phenotypes using short interfering RNA for DNA polymerase H", Cancer Res. 63, 3909-3912.
-
(2003)
Cancer Res.
, vol.63
, pp. 3909-3912
-
-
Laposa, R.R.1
Feeney, L.2
Cleaver, J.E.3
-
79
-
-
0037119943
-
"DEDD regulates degradation of intermediate filaments during apoptosis"
-
Lee, J.C., Schickling, O., Stegh, A.H., Oshima, R.G., Dinsdale, D., Cohen, G.M. and Peter, M.E. (2002) "DEDD regulates degradation of intermediate filaments during apoptosis", J. Cell Biol. 158, 1051-1066.
-
(2002)
J. Cell Biol.
, vol.158
, pp. 1051-1066
-
-
Lee, J.C.1
Schickling, O.2
Stegh, A.H.3
Oshima, R.G.4
Dinsdale, D.5
Cohen, G.M.6
Peter, M.E.7
-
80
-
-
0036311178
-
"Gene silencing in mammalian cells by preformed small RNA duplexes"
-
Leirdal, M. and Sioud, M. (2002) "Gene silencing in mammalian cells by preformed small RNA duplexes", Biochem. Biophys. Res. Commun. 295, 744-748.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.295
, pp. 744-748
-
-
Leirdal, M.1
Sioud, M.2
-
81
-
-
0141988726
-
"Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation"
-
Len, Y.W., Rahmatpanah, F., Shi, H., Wei, S.H., Liu, J.C., Yan, P.S. and Huang, T.H. (2003) "Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation", Cancer Res. 63, 6110-6115.
-
(2003)
Cancer Res.
, vol.63
, pp. 6110-6115
-
-
Len, Y.W.1
Rahmatpanah, F.2
Shi, H.3
Wei, S.H.4
Liu, J.C.5
Yan, P.S.6
Huang, T.H.7
-
82
-
-
0031689425
-
"Development of a sustained-release biodegradable polymer system for site-specific delivery of oligonucleotides: Characterization of P(LA-GA) copolymer microspheres in vitro"
-
Lewis, K.J., Irwin, W.J. and Akhtar, S. (1998) "Development of a sustained-release biodegradable polymer system for site-specific delivery of oligonucleotides: characterization of P(LA-GA) copolymer microspheres in vitro", J. Drug Target. 5, 291-302.
-
(1998)
J. Drug Target.
, vol.5
, pp. 291-302
-
-
Lewis, K.J.1
Irwin, W.J.2
Akhtar, S.3
-
83
-
-
0036727416
-
"Efficient delivery of siRNA for inhibition of gene expression in postnatal mice"
-
Lewis, D.L., Hagstrom, J.E., Loomis, A.G., Wolff, J.A. and Herweijer, H. (2002) "Efficient delivery of siRNA for inhibition of gene expression in postnatal mice", Nat. Genet. 32, 107-108.
-
(2002)
Nat. Genet.
, vol.32
, pp. 107-108
-
-
Lewis, D.L.1
Hagstrom, J.E.2
Loomis, A.G.3
Wolff, J.A.4
Herweijer, H.5
-
84
-
-
0141569812
-
"Interfering with disease: Opportunities and roadblocks to harnessing RNA interference"
-
Lieberman, J., Song, E., Lee, S.K. and Shankar, P. (2003) "Interfering with disease: opportunities and roadblocks to harnessing RNA interference", Trends Mol. Med. 9, 397-403.
-
(2003)
Trends Mol. Med.
, vol.9
, pp. 397-403
-
-
Lieberman, J.1
Song, E.2
Lee, S.K.3
Shankar, P.4
-
85
-
-
0002034191
-
"Cell-penetrating peptides"
-
Lindgren, M., Hallbrink, M., Prochiantz, A. and Langel, U. (2000) "Cell-penetrating peptides", Trends Pharmacol. Sci. 21, 99-103.
-
(2000)
Trends Pharmacol. Sci.
, vol.21
, pp. 99-103
-
-
Lindgren, M.1
Hallbrink, M.2
Prochiantz, A.3
Langel, U.4
-
86
-
-
0345359925
-
"Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain"
-
Lingel, A., Simon, B., Izaurralde, E. and Sattler, M. (2003) "Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain", Nature 426, 465-469.
-
(2003)
Nature
, vol.426
, pp. 465-469
-
-
Lingel, A.1
Simon, B.2
Izaurralde, E.3
Sattler, M.4
-
87
-
-
0141868916
-
"R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway"
-
Liu, Q., Rand, T.A., Kalidas, S., Du, F., Kim, H.E., Smith, D.P. and Wang, X. (2003) "R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway", Science 301, 1921-1925.
-
(2003)
Science
, vol.301
, pp. 1921-1925
-
-
Liu, Q.1
Rand, T.A.2
Kalidas, S.3
Du, F.4
Kim, H.E.5
Smith, D.P.6
Wang, X.7
-
88
-
-
0024199289
-
"Delivery of c-myc antisense phosphorothioate oligodeoxy-nucleotides to hematopoictic cells in culture by liposome fusion: Specific reduction in c-myc protein expression correlates with inhibition of cell growth and DNA synthesis"
-
Loke, S.L., Stein, C., Zhang, X., Avigan, M., Cohen, J. and Neckers, L.M. (1988) "Delivery of c-myc antisense phosphorothioate oligodeoxy-nucleotides to hematopoictic cells in culture by liposome fusion: specific reduction in c-myc protein expression correlates with inhibition of cell growth and DNA synthesis", Curr. Top. Microbiol. Immunol. 141, 282-289.
-
(1988)
Curr. Top. Microbiol. Immunol.
, vol.141
, pp. 282-289
-
-
Loke, S.L.1
Stein, C.2
Zhang, X.3
Avigan, M.4
Cohen, J.5
Neckers, L.M.6
-
89
-
-
0141942113
-
"A brief introduction to cell-penetrating peptides"
-
Lundberg, P. and Langel, U. (2003) "A brief introduction to cell-penetrating peptides", J. Mol. Recognit. 16, 227-233.
-
(2003)
J. Mol. Recognit.
, vol.16
, pp. 227-233
-
-
Lundberg, P.1
Langel, U.2
-
90
-
-
1942488998
-
"The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region"
-
Luo, K.Q. and Chang, D.C. (2004) "The gene-silencing efficiency of siRNA is strongly dependent on the local structure of mRNA at the targeted region", Biochem. Biophys. Res. Commun. 318, 303-310.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.318
, pp. 303-310
-
-
Luo, K.Q.1
Chang, D.C.2
-
91
-
-
0037038758
-
"Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake"
-
Makimura, H., Mizuno, T.M., Mastaitis, J.W., Agami, R. and Mobbs, C.V. (2002) "Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake", BMC Neurosci. 3, 18.
-
(2002)
BMC Neurosci.
, vol.3
, pp. 18
-
-
Makimura, H.1
Mizuno, T.M.2
Mastaitis, J.W.3
Agami, R.4
Mobbs, C.V.5
-
92
-
-
0037031576
-
"Single-stranded antisense siRNAs guide target RNA cleavage in RNAi"
-
Martinez, J., Patkaniowska, A., Urlaub, H., Luhrmann, R. and Tuschl, T. (2002) "Single-stranded antisense siRNAs guide target RNA cleavage in RNAi", Cell 110, 563-574.
-
(2002)
Cell
, vol.110
, pp. 563-574
-
-
Martinez, J.1
Patkaniowska, A.2
Urlaub, H.3
Luhrmann, R.4
Tuschl, T.5
-
93
-
-
2442495329
-
"RISC is a 5′ phosphomonoester-producing RNA endonuclease"
-
Martinez, J. and Tuschl, T. (2004) "RISC is a 5′ phosphomonoester-producing RNA endonuclease", Genes Dev. 18, 975-980.
-
(2004)
Genes Dev.
, vol.18
, pp. 975-980
-
-
Martinez, J.1
Tuschl, T.2
-
94
-
-
4644302416
-
"Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice"
-
in press
-
Massaro, D., Massaro, G.D. and Clerch, L.B. (2004) "Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice", Am. J. Physiol. Lung Cell. Mol. Physiol., in press.
-
(2004)
Am. J. Physiol. Lung Cell Mol. Physiol.
-
-
Massaro, D.1
Massaro, G.D.2
Clerch, L.B.3
-
95
-
-
0033591465
-
"Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure"
-
Mathews, D.H., Sabina, J., Zuker, M. and Turner, D.H, (1999) "Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure", J. Mol. Biol. 288, 911-940.
-
(1999)
J. Mol. Biol.
, vol.288
, pp. 911-940
-
-
Mathews, D.H.1
Sabina, J.2
Zuker, M.3
Turner, D.H.4
-
96
-
-
0037310947
-
"The Tudor domain Royal Family: Tudor, plant Agenet, Chromo, PWWP and MBT domains"
-
Maurer-Stroh, S., Dickens, N.J., Hughes-Davies, L., Kouzarides, T., Eisenhaber, F. and Pouting, C.P. (2003) "The Tudor domain Royal Family: Tudor, plant Agenet, Chromo, PWWP and MBT domains", Trends Biochem. Sci. 28, 69-74.
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 69-74
-
-
Maurer-Stroh, S.1
Dickens, N.J.2
Hughes-Davies, L.3
Kouzarides, T.4
Eisenhaber, F.5
Pouting, C.P.6
-
97
-
-
0037019339
-
"RNA interference in adult mice"
-
McCaffrey, A.P., Meuse, L., Pham, T.T., Conklin, D.S., Hannon, G.J. and Kay, M.A. (2002) "RNA interference in adult mice", Nature 418, 38-39.
-
(2002)
Nature
, vol.418
, pp. 38-39
-
-
McCaffrey, A.P.1
Meuse, L.2
Pham, T.T.3
Conklin, D.S.4
Hannon, G.J.5
Kay, M.A.6
-
98
-
-
0036788304
-
"Gene silencing in mammals by small interfering RNAs"
-
McManus, M.T. and Sharp, P.A. (2002) "Gene silencing in mammals by small interfering RNAs", Nat. Rev. Genet. 3, 737-747.
-
(2002)
Nat. Rev. Genet.
, vol.3
, pp. 737-747
-
-
McManus, M.T.1
Sharp, P.A.2
-
99
-
-
0037111232
-
"Small interfering RNA-mediated gene silencing in T lymphocytes"
-
McManus, M.T., Haines, B.B., Dillon, C.P., Whitehurst, C.E., van Parijs, L., Chen, J. and Sharp, P.A. (2002) "Small interfering RNA-mediated gene silencing in T lymphocytes", J. Immunol. 169, 5754-5760.
-
(2002)
J. Immunol.
, vol.169
, pp. 5754-5760
-
-
McManus, M.T.1
Haines, B.B.2
Dillon, C.P.3
Whitehurst, C.E.4
van Parijs, L.5
Chen, J.6
Sharp, P.A.7
-
100
-
-
3042704068
-
"Optimizing RNA interference for application in mammalian cells"
-
in press
-
Medema, R.H. (2004) "Optimizing RNA interference for application in mammalian cells", Biochem. J., in press.
-
(2004)
Biochem. J.
-
-
Medema, R.H.1
-
101
-
-
1842530980
-
"Generation of an shRNAi expression library against the whole human transcripts"
-
Miyagishi, M., Matsumoto, S. and Taira, K. (2004) "Generation of an shRNAi expression library against the whole human transcripts", Virus Res. 102, 117-124.
-
(2004)
Virus Res.
, vol.102
, pp. 117-124
-
-
Miyagishi, M.1
Matsumoto, S.2
Taira, K.3
-
102
-
-
0041328844
-
"In vivo gene silencing in Plasmodium berghei - A mouse malaria model"
-
Mohmmed, A., Dasaradhi, P.V., Bhatnagar, R.K., Chauhan, V.S. and Malhotra, P. (2003) "In vivo gene silencing in Plasmodium berghei - a mouse malaria model", Biochem. Biophys. Res. Commun. 309, 506-511.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.309
, pp. 506-511
-
-
Mohmmed, A.1
Dasaradhi, P.V.2
Bhatnagar, R.K.3
Chauhan, V.S.4
Malhotra, P.5
-
103
-
-
0027168725
-
"Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression"
-
Monia, B.P., Lesnik, E.A., Gonzalez, C., Lima, W.F., McGee, D., Guinosso, C.J., Kawasaki, A.M., Cook, P.D. and Freier, S.M. (1993) "Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression", J. Biol. Chem. 268, 14514-14522.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 14514-14522
-
-
Monia, B.P.1
Lesnik, E.A.2
Gonzalez, C.3
Lima, W.F.4
McGee, D.5
Guinosso, C.J.6
Kawasaki, A.M.7
Cook, P.D.8
Freier, S.M.9
-
104
-
-
0029977448
-
"Antitumor activity of a phosphorothioate antisense oligodeoxy-nucleotide targeted against C-raf kinase"
-
Monia, B.P., Johnston, J.F., Geiger, T., Muller, M. and Fabbro, D. (1996) "Antitumor activity of a phosphorothioate antisense oligodeoxy-nucleotide targeted against C-raf kinase", Nat. Med. 2, 668-675.
-
(1996)
Nat. Med.
, vol.2
, pp. 668-675
-
-
Monia, B.P.1
Johnston, J.F.2
Geiger, T.3
Muller, M.4
Fabbro, D.5
-
105
-
-
0030804766
-
"A new peptide vector for efficient delivery of oligonucleotides into mammalian cells"
-
Morris, M.C., Vidal, P., Chaloin, L., Heitz, F. and Divita, G. (1997) "A new peptide vector for efficient delivery of oligonucleotides into mammalian cells", Nucleic Acids Res. 25, 2730-2736.
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 2730-2736
-
-
Morris, M.C.1
Vidal, P.2
Chaloin, L.3
Heitz, F.4
Divita, G.5
-
106
-
-
0033199787
-
"A novel potent strategy for gene delivery using a single peptide vector as a carrier"
-
Morris, M.C., Chaloin, L., Mery, J., Heitz, F. and Divita, G. (1999) "A novel potent strategy for gene delivery using a single peptide vector as a carrier", Nucleic Acids Res. 27, 3510-3517.
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 3510-3517
-
-
Morris, M.C.1
Chaloin, L.2
Mery, J.3
Heitz, F.4
Divita, G.5
-
107
-
-
0842346326
-
"Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells"
-
Muratovska, A. and Eccles, M.R. (2004) "Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells", FEBS Lett. 558, 63-68.
-
(2004)
FEBS Lett.
, vol.558
, pp. 63-68
-
-
Muratovska, A.1
Eccles, M.R.2
-
108
-
-
0034658666
-
"Toxicity of cationic liposome-DNA complex in lung isografts"
-
Nagahiro, I., Mora, B.N., Boasquevisque, C.H., Scheule, R.K. and Patterson, G.A. (2000) "Toxicity of cationic liposome-DNA complex in lung isografts", Transplantation 69, 1802-1805.
-
(2000)
Transplantation
, vol.69
, pp. 1802-1805
-
-
Nagahiro, I.1
Mora, B.N.2
Boasquevisque, C.H.3
Scheule, R.K.4
Patterson, G.A.5
-
109
-
-
0042326510
-
"Improved transfection efficiency of cultured human cells"
-
Nikcevic, G., Kovacevic-Grujicic, N. and Stevanovic, M. (2003) "Improved transfection efficiency of cultured human cells", Cell Biol. Int. 27, 735-737.
-
(2003)
Cell Biol. Int.
, vol.27
, pp. 735-737
-
-
Nikcevic, G.1
Kovacevic-Grujicic, N.2
Stevanovic, M.3
-
110
-
-
0037291214
-
"The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase"
-
North, B.J., Marshall, B.L., Borra, M.T., Denu, J.M. and Verdin, E. (2003) "The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase", Mol. Cell 11, 437-444.
-
(2003)
Mol. Cell
, vol.11
, pp. 437-444
-
-
North, B.J.1
Marshall, B.L.2
Borra, M.T.3
Denu, J.M.4
Verdin, E.5
-
111
-
-
0035798415
-
"ATP requirements and small interfering RNA structure in the RNA interference pathway"
-
Nykanen, A., Haley, B. and Zamore, P.D. (2001) "ATP requirements and small interfering RNA structure in the RNA interference pathway", Cell 107, 309-321.
-
(2001)
Cell
, vol.107
, pp. 309-321
-
-
Nykanen, A.1
Haley, B.2
Zamore, P.D.3
-
112
-
-
0342626578
-
"The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling"
-
Oelgeschlager, M., Larrain, J., Geissert, D. and De Robertis, E.M. (2000) "The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling", Nature 405, 757-763.
-
(2000)
Nature
, vol.405
, pp. 757-763
-
-
Oelgeschlager, M.1
Larrain, J.2
Geissert, D.3
De Robertis, E.M.4
-
113
-
-
0347756922
-
"Toxicogenomics of non-viral vectors for gene therapy: A microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells"
-
Omidi, Y., Hollins, A.J., Benboubetra, M., Drayton, R., Benter, I.F. and Akhtar, S. (2003) "Toxicogenomics of non-viral vectors for gene therapy: a microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells", J. Drug Target. 11, 311-323.
-
(2003)
J. Drug Target.
, vol.11
, pp. 311-323
-
-
Omidi, Y.1
Hollins, A.J.2
Benboubetra, M.3
Drayton, R.4
Benter, I.F.5
Akhtar, S.6
-
114
-
-
0033634682
-
"Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference"
-
Parrish, S., Fleenor, J., Xu, S., Mello, C. and Fire, A. (2000) "Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference", Mol. Cell 6, 1077-1087.
-
(2000)
Mol. Cell
, vol.6
, pp. 1077-1087
-
-
Parrish, S.1
Fleenor, J.2
Xu, S.3
Mello, C.4
Fire, A.5
-
115
-
-
0035946624
-
"Cationic lipid-DNA complexes in gene delivery: From biophysics to biological applications"
-
Pedroso de Lima, M.C., Simoes, S., Pires, P., Faneca, H. and Duzgunes, N. (2001) "Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications", Adv. Drug Deliv. Rev. 47, 277-294.
-
(2001)
Adv. Drug Deliv. Rev.
, vol.47
, pp. 277-294
-
-
Pedroso de Lima, M.C.1
Simoes, S.2
Pires, P.3
Faneca, H.4
Duzgunes, N.5
-
116
-
-
0347623204
-
"Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)"
-
Persengiev, S.P., Zhu, X. and Green, M.R. (2004) "Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)", RNA 10, 12-18.
-
(2004)
RNA
, vol.10
, pp. 12-18
-
-
Persengiev, S.P.1
Zhu, X.2
Green, M.R.3
-
117
-
-
0041428216
-
"Messenger RNA expression profiling of genes involved in epidermal growth factor receptor signalling in human cancer cells treated with scanning array-designed antisense oligonucleotides"
-
Petch, A.K., Sohail, M., Hughes, M.D., Benter, I., Darling, J., Southern, E.M. and Akhtar, S. (2003) "Messenger RNA expression profiling of genes involved in epidermal growth factor receptor signalling in human cancer cells treated with scanning array-designed antisense oligonucleotides", Biochem. Pharmacol. 66, 819-830.
-
(2003)
Biochem. Pharmacol.
, vol.66
, pp. 819-830
-
-
Petch, A.K.1
Sohail, M.2
Hughes, M.D.3
Benter, I.4
Darling, J.5
Southern, E.M.6
Akhtar, S.7
-
118
-
-
1842766252
-
"A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila"
-
Pham, J.W., Pellino, J.L., Lee, Y.S., Carthew, R.W. and Sontheimer, E.J. (2004) "A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila", Cell 117, 83-94.
-
(2004)
Cell
, vol.117
, pp. 83-94
-
-
Pham, J.W.1
Pellino, J.L.2
Lee, Y.S.3
Carthew, R.W.4
Sontheimer, E.J.5
-
119
-
-
0034774810
-
"Efficiency and toxicity of liposome-mediated gene transfer to corneal endothelial cells"
-
Pleyer, U., Groth, D., Hinz, B., Keil, O., Bertelmann, E., Rieck, P. and Reszka, R. (2001) "Efficiency and toxicity of liposome-mediated gene transfer to corneal endothelial cells", Exp. Eye Res. 73, 1-7.
-
(2001)
Exp. Eye Res.
, vol.73
, pp. 1-7
-
-
Pleyer, U.1
Groth, D.2
Hinz, B.3
Keil, O.4
Bertelmann, E.5
Rieck, P.6
Reszka, R.7
-
120
-
-
0031754150
-
"Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo"
-
Pooga, M., Soomets, U., Hallbrink, M., Valkna, A., Saar, K., Rezaei, K., Kahl, U., Hao, J.X., Xu, X.J., Wiesenfeld-Hallin, Z., Hokfelt, T., Bartfai, T. and Langel, U. (1998) "Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo", Nat. Biotechnol. 16, 857-861.
-
(1998)
Nat. Biotechnol.
, vol.16
, pp. 857-861
-
-
Pooga, M.1
Soomets, U.2
Hallbrink, M.3
Valkna, A.4
Saar, K.5
Rezaei, K.6
Kahl, U.7
Hao, J.X.8
Xu, X.J.9
Wiesenfeld-Hallin, Z.10
Hokfelt, T.11
Bartfai, T.12
Langel, U.13
-
121
-
-
0037193461
-
"Human Speedy: A novel cell cycle regulator that enhances proliferation through activation of Cdk2"
-
Porter, L.A., Dellinger, R.W., Tynan, J.A., Barnes, E.A., Kong, M., Lenormand, J.L. and Donoghue, D.J. (2002) "Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2", J. Cell Biol. 157, 357-366.
-
(2002)
J. Cell Biol.
, vol.157
, pp. 357-366
-
-
Porter, L.A.1
Dellinger, R.W.2
Tynan, J.A.3
Barnes, E.A.4
Kong, M.5
Lenormand, J.L.6
Donoghue, D.J.7
-
122
-
-
0041529844
-
"11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1"
-
Potente, M., Fisslthaler, B., Busse, R. and Fleming, I. (2003) "11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1", J. Biol. Chem. 278, 29619-29625.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 29619-29625
-
-
Potente, M.1
Fisslthaler, B.2
Busse, R.3
Fleming, I.4
-
123
-
-
0142169015
-
"A recombinant H1 histone-based system for efficient delivery of nucleic acids"
-
Puebla, I., Esseghir, S., Mortlock, A., Brown, A., Crisanti, A. and Low, W. (2003) "A recombinant H1 histone-based system for efficient delivery of nucleic acids", J. Biotechnol. 105, 215-226.
-
(2003)
J. Biotechnol.
, vol.105
, pp. 215-226
-
-
Puebla, I.1
Esseghir, S.2
Mortlock, A.3
Brown, A.4
Crisanti, A.5
Low, W.6
-
124
-
-
0038748037
-
"Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model"
-
Reich, S.J., Fosnot, J., Kuroki, A., Tang, W., Yang, X., Maguire, A.M., Bennett, J. and Tolentino, M.J. (2003) "Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model", Mol. Vis. 9, 210-216.
-
(2003)
Mol. Vis.
, vol.9
, pp. 210-216
-
-
Reich, S.J.1
Fosnot, J.2
Kuroki, A.3
Tang, W.4
Yang, X.5
Maguire, A.M.6
Bennett, J.7
Tolentino, M.J.8
-
125
-
-
1542336952
-
"Rational siRNA design for RNA interference"
-
Reynolds, A., Leake, D., Boese, Q., Scaringe, S., Marshall, W.S. and Khvorova, A. (2004) "Rational siRNA design for RNA interference", Nat. Biotechnol. 22, 326-330.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 326-330
-
-
Reynolds, A.1
Leake, D.2
Boese, Q.3
Scaringe, S.4
Marshall, W.S.5
Khvorova, A.6
-
126
-
-
0346460957
-
"Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake"
-
Richard, J.P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M.J., Chernomordik, L.V. and Lebleu, B. (2003) "Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake", J. Biol. Chem. 278, 585-590.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 585-590
-
-
Richard, J.P.1
Melikov, K.2
Vives, E.3
Ramos, C.4
Verbeure, B.5
Gait, M.J.6
Chernomordik, L.V.7
Lebleu, B.8
-
127
-
-
0030987371
-
"Cell-surface perturbations of the epidermal growth factor and vascular endothelial growth factor receptors by phosphorothioate oligodeoxynucleotides"
-
Rockwell, P., O'Connor, W.J., King, K., Goldstein, N.I., Zhang, L.M. and Stein, C.A. (1997) "Cell-surface perturbations of the epidermal growth factor and vascular endothelial growth factor receptors by phosphorothioate oligodeoxynucleotides", Proc. Natl Acad. Sci. USA 94, 6523-6528.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 6523-6528
-
-
Rockwell, P.1
O'Connor, W.J.2
King, K.3
Goldstein, N.I.4
Zhang, L.M.5
Stein, C.A.6
-
128
-
-
0028241377
-
"Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate"
-
Sands, H., Gorey-Feret, L.J., Cocuzza, A.J., Hobbs, F.W., Chidester, D. and Trainor, G.L. (1994) "Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate", Mol. Pharmacol. 45, 932-943.
-
(1994)
Mol. Pharmacol.
, vol.45
, pp. 932-943
-
-
Sands, H.1
Gorey-Feret, L.J.2
Cocuzza, A.J.3
Hobbs, F.W.4
Chidester, D.5
Trainor, G.L.6
-
129
-
-
1642498310
-
"Pharmaceutical prospects for RNA interference"
-
Schiffelers, R.M., Woodle, M.C. and Scaria, P. (2004) "Pharmaceutical prospects for RNA interference", Pharm. Res. 21, 1-7.
-
(2004)
Pharm. Res.
, vol.21
, pp. 1-7
-
-
Schiffelers, R.M.1
Woodle, M.C.2
Scaria, P.3
-
130
-
-
0036752955
-
"Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways"
-
Schwarz, D.S., Hutvagner, G., Haley, B. and Zamore, P.D. (2002) "Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways", Mol. Cell 10, 537-548.
-
(2002)
Mol. Cell
, vol.10
, pp. 537-548
-
-
Schwarz, D.S.1
Hutvagner, G.2
Haley, B.3
Zamore, P.D.4
-
131
-
-
10744225153
-
"Asymmetry in the assembly of the RNAi enzyme complex"
-
Schwarz, D.S., Hutvagner, G., Du, T., Xu, Z., Aronin, N. and Zamore, P.D. (2003) "Asymmetry in the assembly of the RNAi enzyme complex", Cell 115, 199-208.
-
(2003)
Cell
, vol.115
, pp. 199-208
-
-
Schwarz, D.S.1
Hutvagner, G.2
Du, T.3
Xu, Z.4
Aronin, N.5
Zamore, P.D.6
-
132
-
-
2342626647
-
"The RNA-induced silencing complex is a Mg2+-dependent endonuclease"
-
Schwarz, D.S., Tomari, Y. and Zamore, P.D. (2004) "The RNA-induced silencing complex is a Mg2+-dependent endonuclease", Curr. Biol. 14, 787-791.
-
(2004)
Curr. Biol.
, vol.14
, pp. 787-791
-
-
Schwarz, D.S.1
Tomari, Y.2
Zamore, P.D.3
-
133
-
-
0038121109
-
"Specificity of short interfering RNA determined through gene expression signatures"
-
Semizarov, D., Frost, L., Sarthy, A., Kroeger, P., Halbert, D.N. and Fesik, S.W. (2003) "Specificity of short interfering RNA determined through gene expression signatures", Proc. Natl Acad. Sci. USA 100, 6347-6352.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 6347-6352
-
-
Semizarov, D.1
Frost, L.2
Sarthy, A.3
Kroeger, P.4
Halbert, D.N.5
Fesik, S.W.6
-
134
-
-
0026040132
-
"Mechanism of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkages"
-
Shoji, Y., Akhtar, S., Periasamy, A., Herman, B. and Juliano, R.L. (1991) "Mechanism of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkages", Nucleic Acids Res. 19, 5543-5550.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 5543-5550
-
-
Shoji, Y.1
Akhtar, S.2
Periasamy, A.3
Herman, B.4
Juliano, R.L.5
-
135
-
-
0037592877
-
"Insight into the mechanism of the peptide-based gene delivery system MPG: Implications for delivery of siRNA into mammalian cells"
-
Simeoni, F., Morris, M.C., Heitz, F. and Divita, G. (2003) "Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells" , Nucleic Acids Res. 31, 2717-2724.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 2717-2724
-
-
Simeoni, F.1
Morris, M.C.2
Heitz, F.3
Divita, G.4
-
136
-
-
0346024002
-
"Therapeutic siRNAs"
-
Sioud, M. (2004) "Therapeutic siRNAs", Trends Pharmacol. Sci. 25, 22-28.
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 22-28
-
-
Sioud, M.1
-
137
-
-
0042972933
-
"Activation of the interferon system by short-interfering RNAs"
-
Sledz, C.A., Holko, M., de Veer, M.J., Silverman, R.H. and Williams, B.R. (2003) "Activation of the interferon system by short-interfering RNAs", Nat. Cell Biol. 5, 834-839.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 834-839
-
-
Sledz, C.A.1
Holko, M.2
de Veer, M.J.3
Silverman, R.H.4
Williams, B.R.5
-
138
-
-
0033860727
-
"Rational selection of antisense oligonucleotide sequences"
-
Smith, L., Andersen, K.B., Hovgaard, L. and Jaroszewski, J.W. (2000) "Rational selection of antisense oligonucleotide sequences", Eur. J. Pharm. Sci. 11, 191-198.
-
(2000)
Eur. J. Pharm. Sci.
, vol.11
, pp. 191-198
-
-
Smith, L.1
Andersen, K.B.2
Hovgaard, L.3
Jaroszewski, J.W.4
-
139
-
-
0034739611
-
"Selecting optimal antisense reagents"
-
Sohail, M. and Southern, E.M. (2000) "Selecting optimal antisense reagents", Adv. Drug Deliv. Rev. 44, 23-34.
-
(2000)
Adv. Drug Deliv. Rev.
, vol.44
, pp. 23-34
-
-
Sohail, M.1
Southern, E.M.2
-
140
-
-
0035873670
-
"Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo"
-
Sohail, M., Hochegger, H., Klotzbucher, A., Guellec, R.L., Hunt, T. and Southern, E.M. (2001) "Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo", Nucleic Acids Res. 29, 2041-2051.
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 2041-2051
-
-
Sohail, M.1
Hochegger, H.2
Klotzbucher, A.3
Guellec, R.L.4
Hunt, T.5
Southern, E.M.6
-
141
-
-
0037348329
-
"RNA interference targeting Fas protects mice from fulminant hepatitis"
-
Song, E., Lee, S.K., Wang, J., Ince, N., Ouyang, N., Min, J., Chen, J., Shankar, P. and Lieberman, J. (2003a) "RNA interference targeting Fas protects mice from fulminant hepatitis", Nat. Med. 9, 347-351.
-
(2003)
Nat. Med.
, vol.9
, pp. 347-351
-
-
Song, E.1
Lee, S.K.2
Wang, J.3
Ince, N.4
Ouyang, N.5
Min, J.6
Chen, J.7
Shankar, P.8
Lieberman, J.9
-
142
-
-
0345490960
-
"The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes"
-
Song, J.J., Liu, J., Tolia, N.H., Schneiderman, J., Smith, S.K., Martienssen, R.A., Hannon, G.J. and Joshua-Tor, L. (2003b) " The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes", Nat. Struct. Biol. 10, 1026-1032.
-
(2003)
Nat. Struct. Biol.
, vol.10
, pp. 1026-1032
-
-
Song, J.J.1
Liu, J.2
Tolia, N.H.3
Schneiderman, J.4
Smith, S.K.5
Martienssen, R.A.6
Hannon, G.J.7
Joshua-Tor, L.8
-
143
-
-
0141552295
-
"Gene silencing by systemic delivery of synthetic siRNAs in adult mice"
-
Sorensen, D.R., Leirdal, M. and Sioud, M. (2003) "Gene silencing by systemic delivery of synthetic siRNAs in adult mice", J. Mol. Biol. 327, 761-766.
-
(2003)
J. Mol. Biol.
, vol.327
, pp. 761-766
-
-
Sorensen, D.R.1
Leirdal, M.2
Sioud, M.3
-
144
-
-
0031657551
-
"How cells respond to interferons"
-
Stark, G.R., Kerr, I.M., Williams, B.R., Silverman, R.H. and Schreiber, R.D. (1998) "How cells respond to interferons", Annu. Rev. Biochem. 67, 227-264.
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 227-264
-
-
Stark, G.R.1
Kerr, I.M.2
Williams, B.R.3
Silverman, R.H.4
Schreiber, R.D.5
-
145
-
-
0032087142
-
"Structural polymorphism of lipids and effectiveness of gene delivery"
-
Tarahovsky, Y.S. and Ivanitsky, G.R. (1998) "Structural polymorphism of lipids and effectiveness of gene delivery", Biochemistry (Mosc) 63, 607-618.
-
(1998)
Biochemistry (Mosc.)
, vol.63
, pp. 607-618
-
-
Tarahovsky, Y.S.1
Ivanitsky, G.R.2
-
146
-
-
0012767432
-
"Nucleic acid recognition by OB-fold proteins"
-
Theobald, D.L., Mitton-Fry, R.M. and Wuttke, D.S. (2003) "Nucleic acid recognition by OB-fold proteins", Annu. Rev. Biophys. Biomol. Struct. 32, 115-133.
-
(2003)
Annu. Rev. Biophys. Biomol. Struct.
, vol.32
, pp. 115-133
-
-
Theobald, D.L.1
Mitton-Fry, R.M.2
Wuttke, D.S.3
-
147
-
-
0028849686
-
"Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse"
-
Theodore, L., Derossi, D., Chassaing, G., Llirbat, B., Kubes, M., Jordan, P., Chneiweiss, H., Godement, P. and Prochiantz, A. (1995) "Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse", J. Neurosci. 15, 7158-7167.
-
(1995)
J. Neurosci.
, vol.15
, pp. 7158-7167
-
-
Theodore, L.1
Derossi, D.2
Chassaing, G.3
Llirbat, B.4
Kubes, M.5
Jordan, P.6
Chneiweiss, H.7
Godement, P.8
Prochiantz, A.9
-
148
-
-
0036953376
-
"The genetics of RNAsilencing"
-
Tijsterman, M., Ketting, R.F. and Plasterk, R.H. (2002) "The genetics of RNAsilencing", Annu. Rev. Genet. 36, 489-519.
-
(2002)
Annu. Rev. Genet.
, vol.36
, pp. 489-519
-
-
Tijsterman, M.1
Ketting, R.F.2
Plasterk, R.H.3
-
149
-
-
1242297011
-
"Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization"
-
Tolentino, M.J., Brucker, A.J., Fosnot, J., Ying, G.S., Wu, I.H., Malik, G., Wan, S. and Reich, S.J. (2004) "Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization", Retina 24, 132-138.
-
(2004)
Retina
, vol.24
, pp. 132-138
-
-
Tolentino, M.J.1
Brucker, A.J.2
Fosnot, J.3
Ying, G.S.4
Wu, I.H.5
Malik, G.6
Wan, S.7
Reich, S.J.8
-
150
-
-
0035902477
-
"TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors"
-
Torchilin, V.P., Rammohan, R., Weissig, V. and Levchenko, T.S. (2001) "TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors", Proc. Natl Acad. Sci. USA 98, 8786-8791.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8786-8791
-
-
Torchilin, V.P.1
Rammohan, R.2
Weissig, V.3
Levchenko, T.S.4
-
151
-
-
0037666792
-
"Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation"
-
Troussard, A.A., Mawji, N.M., Ong, C., Mui, A., St -Arnaud, R. and Dedhar, S. (2003) "Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation", J. Biol. Chem. 278, 22374-22378.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22374-22378
-
-
Troussard, A.A.1
Mawji, N.M.2
Ong, C.3
Mui, A.4
St-Arnaud, R.5
Dedhar, S.6
-
152
-
-
0037175385
-
"Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration"
-
Tsubouchi, A., Sakakura, J., Yagi, R., Mazaki, Y., Schaefer, E., Yano, H. and Sabe, H. (2002) "Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration", J. Cell Biol. 159, 673-683.
-
(2002)
J. Cell Biol.
, vol.159
, pp. 673-683
-
-
Tsubouchi, A.1
Sakakura, J.2
Yagi, R.3
Mazaki, Y.4
Schaefer, E.5
Yano, H.6
Sabe, H.7
-
153
-
-
1642346273
-
"Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference"
-
Ui-Tei, K., Naito, Y., Takahashi, F., Haraguchi, T., Ohki-Hamazaki, H., Juni, A., Ueda, R. and Saigo, K. (2004) " Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference", Nucleic Acids Res. 32, 936-948.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 936-948
-
-
Ui-Tei, K.1
Naito, Y.2
Takahashi, F.3
Haraguchi, T.4
Ohki-Hamazaki, H.5
Juni, A.6
Ueda, R.7
Saigo, K.8
-
154
-
-
0038190982
-
"Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes"
-
Usui, I., Imamura, T., Huang, J., Satoh, H. and Olefsky, J.M. (2003) "Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes", J. Biol. Chem. 278, 13765-13774.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13765-13774
-
-
Usui, I.1
Imamura, T.2
Huang, J.3
Satoh, H.4
Olefsky, J.M.5
-
155
-
-
0037388638
-
"Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells"
-
Verma, U.N., Surabhi, R.M., Schmaltieg, A., Becerra, C. and Gaynor, R.B. (2003) "Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells", Clin. Cancer Res. 9, 1291-1300.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1291-1300
-
-
Verma, U.N.1
Surabhi, R.M.2
Schmaltieg, A.3
Becerra, C.4
Gaynor, R.B.5
-
156
-
-
0037470145
-
"Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis"
-
Vickers, T.A., Koo, S., Bennett, C.F., Crooke, S.T., Dean, N.M. and Baker, B.F. (2003) "Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis", J. Biol. Chem. 278, 7108-7118.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 7108-7118
-
-
Vickers, T.A.1
Koo, S.2
Bennett, C.F.3
Crooke, S.T.4
Dean, N.M.5
Baker, B.F.6
-
157
-
-
0041701755
-
"Herpesvirus saimiri: A potential gene delivery vector (review )"
-
Whitehouse, A. (2003) "Herpesvirus saimiri: a potential gene delivery vector (review)", Int. J. Mol. Med. 11, 139-148.
-
(2003)
Int. J. Mol. Med.
, vol.11
, pp. 139-148
-
-
Whitehouse, A.1
-
158
-
-
0022780091
-
"Oligodeoxynucleotide stability in subcellular extracts and culture media"
-
Wickstrom, E. (1986) "Oligodeoxynucleotide stability in subcellular extracts and culture media", J. Biochem. Biophys. Methods 13,97-102.
-
(1986)
J. Biochem. Biophys. Methods
, vol.13
, pp. 97-102
-
-
Wickstrom, E.1
-
159
-
-
0033990409
-
"Cell-specific optimization of phosphorothioate antisense oligodeoxynucleotide delivery by cationic lipids"
-
Williams, S.A. and Buzby, J.S. (2000) "Cell-specific optimization of phosphorothioate antisense oligodeoxynucleotide delivery by cationic lipids", Methods Enzymol. 313, 388-397.
-
(2000)
Methods Enzymol.
, vol.313
, pp. 388-397
-
-
Williams, S.A.1
Buzby, J.S.2
-
160
-
-
0041630618
-
"Effective small interfering RNAs and phosphorothioate antisense DNAs have different preferences for target sites in the
-
Xu, Y., Zhang, H.Y., Thormeyer, D., Larsson, O., Du, Q., Elmen, J., Wahlestedt, C. and Liang, Z. (2003) "Effective small interfering RNAs and phosphorothioate antisense DNAs have different preferences for target sites in the luciferase mRNAs", Biochem. Biophys. Res. Commun. 306, 712-717.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.306
, pp. 712-717
-
-
Xu, Y.1
Zhang, H.Y.2
Thormeyer, D.3
Larsson, O.4
Du, Q.5
Elmen, J.6
Wahlestedt, C.7
Liang, Z.8
-
161
-
-
0037162522
-
"Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells"
-
Yang, D., Buchholz, F., Huang, Z., Goga, A., Chen, C.Y., Brodsky, F.M. and Bishop, J.M. (2002) "Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells", Proc. Natl Acad. Sci. USA 99, 9942-9947.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 9942-9947
-
-
Yang, D.1
Buchholz, F.2
Huang, Z.3
Goga, A.4
Chen, C.Y.5
Brodsky, F.M.6
Bishop, J.M.7
-
162
-
-
0037462796
-
"Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage"
-
Yoon, H.S., Chen, X. and Yang, V.W. (2003) "Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage", J. Biol. Chem. 278, 2101-2105.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2101-2105
-
-
Yoon, H.S.1
Chen, X.2
Yang, V.W.3
-
163
-
-
0034737298
-
"RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals"
-
Zamore, P.D., Tuschl, T., Sharp, P.A. and Bartel, D.P. (2000) "RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals", Cell 101, 25-33.
-
(2000)
Cell
, vol.101
, pp. 25-33
-
-
Zamore, P.D.1
Tuschl, T.2
Sharp, P.A.3
Bartel, D.P.4
-
164
-
-
0038610713
-
"Caspase 8 small interfering RNA prevents acute liver failure in mice"
-
Zender, L., Hutker, S., Liedtke, C., Tillmann, H.L., Zender, S., Mundt, B., Waltemathe, M., Gosling, T., Flemming, P., Malek, N.P., Trautwein, C., Manns, M.P., Kuhnel, F. and Kubicka, S. (2003) " Caspase 8 small interfering RNA prevents acute liver failure in mice" , Proc. Natl Acad. Sci. USA 100, 7797-7802.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 7797-7802
-
-
Zender, L.1
Hutker, S.2
Liedtke, C.3
Tillmann, H.L.4
Zender, S.5
Mundt, B.6
Waltemathe, M.7
Gosling, T.8
Flemming, P.9
Malek, N.P.10
Trautwein, C.11
Manns, M.P.12
Kuhnel, F.13
Kubicka, S.14
-
165
-
-
0037020234
-
"Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. The potential role of MCL1 as a fortilin chaperone"
-
Zhang, D., Li, F., Weidner, D., Mnjoyan, Z.H. and Fujise, K. (2002) "Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. The potential role of MCL1 as a fortilin chaperone", J. Biol. Chem. 277, 37430-37438.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 37430-37438
-
-
Zhang, D.1
Li, F.2
Weidner, D.3
Mnjoyan, Z.H.4
Fujise, K.5
-
166
-
-
1642291631
-
"Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis"
-
Zhang, X., Shan, P., Jiang, D., Noble, P.W., Abraham, N.G., Kappas, A. and Lee, P.J. (2004) "Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis", J. Biol. Chem. 279, 10677-10684.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 10677-10684
-
-
Zhang, X.1
Shan, P.2
Jiang, D.3
Noble, P.W.4
Abraham, N.G.5
Kappas, A.6
Lee, P.J.7
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