메뉴 건너뛰기




Volumn 18, Issue 1, 2013, Pages 58-79

siRNA delivery: From basics to therapeutic applications

Author keywords

Bioconjugates; Carbonanotubes; Clinical trials; Dendrimers; Lipid based particles; Liposomes; Micelles; Nanogels; Polymer based particles; Review; siRNA; siRNA conjugate; siRNA delivery systems

Indexed keywords

BACTERIOPHAGE T7 RNA POLYMERASE; DNA DIRECTED RNA POLYMERASE; MACROGOL DERIVATIVE; MESSENGER RNA; NANOPARTICLE; SMALL INTERFERING RNA; VIRUS PROTEIN;

EID: 84878773916     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4087     Document Type: Review
Times cited : (44)

References (141)
  • 1
    • 34047190259 scopus 로고    scopus 로고
    • Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting
    • D. De Paula, M.V. Bentley, and R.I. Mahato. Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting. RNA. 13:431-456 (2007)
    • (2007) RNA , vol.13 , pp. 431-456
    • De Paula, D.1    Bentley, M.V.2    Mahato, R.I.3
  • 2
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • S.M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:494-498 (2001)
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 3
    • 0033615491 scopus 로고    scopus 로고
    • A species of small antisense RNA in posttranscriptional gene silencing in plants
    • A.J. HamiltonD.C. Baulcombe. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science. 286:950-952 (1999)
    • (1999) Science , vol.286 , pp. 950-952
    • Hamilton, A.J.1    Baulcombe, D.C.2
  • 5
    • 3242677639 scopus 로고    scopus 로고
    • siRNAs: Applications in functional genomics and potential as therapeutics
    • Y. DorsettT. Tuschl. siRNAs: applications in functional genomics and potential as therapeutics. Nat Rev Drug Discov. 3:318-329 (2004)
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 318-329
    • Dorsett, Y.1    Tuschl, T.2
  • 6
    • 34547228805 scopus 로고    scopus 로고
    • Polymer-based siRNA delivery: Perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery
    • D.J. Gary, N. Puri, and Y.Y. Won. Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery. J Control Release. 121:64-73 (2007)
    • (2007) J Control Release , vol.121 , pp. 64-73
    • Gary, D.J.1    Puri, N.2    Won, Y.Y.3
  • 8
    • 33845216721 scopus 로고    scopus 로고
    • PEG conjugated VEGF siRNA for anti-angiogenic gene therapy
    • S.H. Kim, J.H. Jeong, S.H. Lee, S.W. Kim, and T.G. Park. PEG conjugated VEGF siRNA for anti-angiogenic gene therapy. J Control Release. 116:123-129 (2006)
    • (2006) J Control Release , vol.116 , pp. 123-129
    • Kim, S.H.1    Jeong, J.H.2    Lee, S.H.3    Kim, S.W.4    Park, T.G.5
  • 9
    • 4444220551 scopus 로고    scopus 로고
    • Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells
    • C. Lorenz, P. Hadwiger, M. John, H.P. Vornlocher, and C. Unverzagt. Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells. Bioorg Med Chem Lett. 14:4975-4977 (2004)
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 4975-4977
    • Lorenz, C.1    Hadwiger, P.2    John, M.3    Vornlocher, H.P.4    Unverzagt, C.5
  • 10
    • 34648834877 scopus 로고    scopus 로고
    • Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity
    • S.A. Moschos, S.W. Jones, M.M. Perry, A.E. Williams, J.S. Erjefalt, J.J. Turner, P.J. Barnes, B.S. Sproat, M.J. Gait, and M.A. Lindsay. Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity. Bioconjug Chem. 18:1450-1459 (2007)
    • (2007) Bioconjug Chem , vol.18 , pp. 1450-1459
    • Moschos, S.A.1    Jones, S.W.2    Perry, M.M.3    Williams, A.E.4    Erjefalt, J.S.5    Turner, J.J.6    Barnes, P.J.7    Sproat, B.S.8    Gait, M.J.9    Lindsay, M.A.10
  • 11
    • 0842346326 scopus 로고    scopus 로고
    • Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells
    • A. MuratovskaM.R. Eccles. Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells. FEBS Lett. 558:63-68 (2004)
    • (2004) FEBS Lett , vol.558 , pp. 63-68
    • Muratovska, A.1    Eccles, M.R.2
  • 12
    • 41149179660 scopus 로고    scopus 로고
    • Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol
    • K. Nishina, T. Unno, Y. Uno, T. Kubodera, T. Kanouchi, H. Mizusawa, and T. Yokota. Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol. Mol Ther. 16:734-740 (2008)
    • (2008) Mol Ther , vol.16 , pp. 734-740
    • Nishina, K.1    Unno, T.2    Uno, Y.3    Kubodera, T.4    Kanouchi, T.5    Mizusawa, H.6    Yokota, T.7
  • 14
    • 0001359591 scopus 로고
    • Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans
    • C. Napoli, C. Lemieux, and R. Jorgensen. Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans. Plant Cell. 2:279-289 (1990)
    • (1990) Plant Cell , vol.2 , pp. 279-289
    • Napoli, C.1    Lemieux, C.2    Jorgensen, R.3
  • 15
    • 0025405838 scopus 로고
    • Flavonoid genes in petunia: Addition of a limited number of gene copies may lead to a suppression of gene expression
    • A.R. van der Krol, L.A. Mur, M. Beld, J.N. Mol, and A.R. Stuitje. Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression. Plant Cell. 2:291-299 (1990)
    • (1990) Plant Cell , vol.2 , pp. 291-299
    • Van Der Krol, A.R.1    Mur, L.A.2    Beld, M.3    Mol, J.N.4    Stuitje, A.R.5
  • 16
    • 0028031830 scopus 로고
    • RNA-directed de novo methylation of genomic sequences in plants
    • M. Wassenegger, S. Heimes, L. Riedel, and H.L. Sanger. RNA-directed de novo methylation of genomic sequences in plants. Cell. 76:567-576 (1994)
    • (1994) Cell , vol.76 , pp. 567-576
    • Wassenegger, M.1    Heimes, S.2    Riedel, L.3    Sanger, H.L.4
  • 17
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • A. Fire, S. Xu, M.K. Montgomery, S.A. Kostas, S.E. Driver, and C.C. Mello. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 391:806-811 (1998)
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 18
    • 0030992349 scopus 로고    scopus 로고
    • A similarity between viral defense and gene silencing in plants
    • F. Ratcliff, B.D. Harrison, and D.C. Baulcombe. A similarity between viral defense and gene silencing in plants. Science. 276:1558-1560 (1997)
    • (1997) Science , vol.276 , pp. 1558-1560
    • Ratcliff, F.1    Harrison, B.D.2    Baulcombe, D.C.3
  • 19
    • 2342485506 scopus 로고    scopus 로고
    • miRNAs on the move: MiRNA biogenesis and the RNAi machinery
    • E.P. MurchisonG.J. Hannon. miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol. 16:223-229 (2004)
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 223-229
    • Murchison, E.P.1    Hannon, G.J.2
  • 20
    • 24644446398 scopus 로고    scopus 로고
    • Ribo-gnome: The big world of small RNAs
    • P.D. ZamoreB. Haley. Ribo-gnome: the big world of small RNAs. Science. 309:1519-1524 (2005)
    • (2005) Science , vol.309 , pp. 1519-1524
    • Zamore, P.D.1    Haley, B.2
  • 22
    • 0033555703 scopus 로고    scopus 로고
    • RNAi and double-strand RNA
    • P.A. Sharp. RNAi and double-strand RNA. Genes Dev. 13:139-141 (1999)
    • (1999) Genes Dev , vol.13 , pp. 139-141
    • Sharp, P.A.1
  • 23
    • 4444378185 scopus 로고    scopus 로고
    • Gene therapy progress and prospects. Downregulating gene expression: The impact of RNA interference
    • N.J. Caplen. Gene therapy progress and prospects. Downregulating gene expression: the impact of RNA interference. Gene Ther. 11:1241-1248 (2004)
    • (2004) Gene Ther , vol.11 , pp. 1241-1248
    • Caplen, N.J.1
  • 24
    • 0037089135 scopus 로고    scopus 로고
    • Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor
    • T. Holen, M. Amarzguioui, M.T. Wiiger, E. Babaie, and H. Prydz. Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor. Nucleic Acids Res. 30:1757-1766 (2002)
    • (2002) Nucleic Acids Res , vol.30 , pp. 1757-1766
    • Holen, T.1    Amarzguioui, M.2    Wiiger, M.T.3    Babaie, E.4    Prydz, H.5
  • 25
    • 0141537250 scopus 로고    scopus 로고
    • Enhanced gene silencing by the application of multiple specific small interfering RNAs
    • J. Ji, M. Wernli, T. Klimkait, and P. Erb. Enhanced gene silencing by the application of multiple specific small interfering RNAs. FEBS Lett. 552:247-252 (2003)
    • (2003) FEBS Lett , vol.552 , pp. 247-252
    • Ji, J.1    Wernli, M.2    Klimkait, T.3    Erb, P.4
  • 26
    • 0012756249 scopus 로고    scopus 로고
    • RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase
    • O. DonzeD. Picard. RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase. Nucleic Acids Res. 30:e46 (2002)
    • (2002) Nucleic Acids Res , vol.30
    • Donze, O.1    Picard, D.2
  • 27
    • 0024819449 scopus 로고
    • Synthesis of small RNAs using T7 RNA polymerase
    • J.F. MilliganO.C. Uhlenbeck. Synthesis of small RNAs using T7 RNA polymerase. Methods Enzymol. 180:51-62 (1989)
    • (1989) Methods Enzymol , vol.180 , pp. 51-62
    • Milligan, J.F.1    Uhlenbeck, O.C.2
  • 28
    • 1542306855 scopus 로고    scopus 로고
    • Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
    • D.H. Kim, M. Longo, Y. Han, P. Lundberg, E. Cantin, and J.J. Rossi. Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat Biotechnol. 22:321-325 (2004)
    • (2004) Nat Biotechnol , vol.22 , pp. 321-325
    • Kim, D.H.1    Longo, M.2    Han, Y.3    Lundberg, P.4    Cantin, E.5    Rossi, J.J.6
  • 29
    • 26944498261 scopus 로고    scopus 로고
    • Approaches for chemically synthesized siRNA and vector-mediated RNAi
    • M. Amarzguioui, J.J. Rossi, and D. Kim. Approaches for chemically synthesized siRNA and vector-mediated RNAi. FEBS Lett. 579:5974-5981 (2005)
    • (2005) FEBS Lett , vol.579 , pp. 5974-5981
    • Amarzguioui, M.1    Rossi, J.J.2    Kim, D.3
  • 30
    • 0037686295 scopus 로고    scopus 로고
    • Killing the messenger: Short RNAs that silence gene expression
    • D.M. Dykxhoorn, C.D. Novina, and P.A. Sharp. Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol. 4:457-467 (2003)
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 457-467
    • Dykxhoorn, D.M.1    Novina, C.D.2    Sharp, P.A.3
  • 32
    • 0347063999 scopus 로고    scopus 로고
    • Retrovirus vector-mediated stable gene silencing in human cell
    • C.M. Liu, D.P. Liu, W.J. Dong, and C.C. Liang. Retrovirus vector-mediated stable gene silencing in human cell. Biochem Biophys Res Commun. 313:716-720 (2004)
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 716-720
    • Liu, C.M.1    Liu, D.P.2    Dong, W.J.3    Liang, C.C.4
  • 33
    • 0037841763 scopus 로고    scopus 로고
    • Transcription start regions in the human genome are favored targets for MLV integration
    • X. Wu, Y. Li, B. Crise, and S.M. Burgess. Transcription start regions in the human genome are favored targets for MLV integration. Science. 300:1749-1751 (2003)
    • (2003) Science , vol.300 , pp. 1749-1751
    • Wu, X.1    Li, Y.2    Crise, B.3    Burgess, S.M.4
  • 34
    • 33645136607 scopus 로고    scopus 로고
    • Therapeutic short hairpin RNA expression in the liver: Viral targets and vectors
    • D. GrimmM.A. Kay. Therapeutic short hairpin RNA expression in the liver: viral targets and vectors. Gene Ther. 13:563-575 (2006)
    • (2006) Gene Ther , vol.13 , pp. 563-575
    • Grimm, D.1    Kay, M.A.2
  • 35
    • 0346024002 scopus 로고    scopus 로고
    • Therapeutic siRNAs
    • M. Sioud. Therapeutic siRNAs. Trends Pharmacol Sci. 25:22-28 (2004)
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 22-28
    • Sioud, M.1
  • 36
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • T.R. Brummelkamp, R. Bernards, and R. Agami. A system for stable expression of short interfering RNAs in mammalian cells. Science. 296:550-553 (2002)
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 37
    • 0037089589 scopus 로고    scopus 로고
    • Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
    • P.J. Paddison, A.A. Caudy, E. Bernstein, G.J. Hannon, and D.S. Conklin. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 16:948-958 (2002)
    • (2002) Genes Dev , vol.16 , pp. 948-958
    • Paddison, P.J.1    Caudy, A.A.2    Bernstein, E.3    Hannon, G.J.4    Conklin, D.S.5
  • 38
    • 0036251639 scopus 로고    scopus 로고
    • Effective expression of small interfering RNA in human cells
    • C.P. Paul, P.D. Good, I. Winer, and D.R. Engelke. Effective expression of small interfering RNA in human cells. Nat Biotechnol. 20:505-508 (2002)
    • (2002) Nat Biotechnol , vol.20 , pp. 505-508
    • Paul, C.P.1    Good, P.D.2    Winer, I.3    Engelke, D.R.4
  • 41
    • 0034052609 scopus 로고    scopus 로고
    • Control of the functional activity of an antisense RNA by a tetracycline-responsive derivative of the human U6 snRNA promoter
    • J. OhkawaK. Taira. Control of the functional activity of an antisense RNA by a tetracycline-responsive derivative of the human U6 snRNA promoter. Hum Gene Ther. 11:577-585 (2000)
    • (2000) Hum Gene Ther , vol.11 , pp. 577-585
    • Ohkawa, J.1    Taira, K.2
  • 42
    • 0042662862 scopus 로고    scopus 로고
    • Establishment of conditional vectors for hairpin siRNA knockdowns
    • S. Matsukura, P.A. Jones, and D. Takai. Establishment of conditional vectors for hairpin siRNA knockdowns. Nucleic Acids Res. 31:e77 (2003)
    • (2003) Nucleic Acids Res , vol.31
    • Matsukura, S.1    Jones, P.A.2    Takai, D.3
  • 45
    • 25144464388 scopus 로고    scopus 로고
    • Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice
    • E. Rodriguez-Lebron, E.M. Denovan-Wright, K. Nash, A.S. Lewin, and R.J. Mandel. Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice. Mol Ther. 12:618-633 (2005)
    • (2005) Mol Ther , vol.12 , pp. 618-633
    • Rodriguez-Lebron, E.1    Denovan-Wright, E.M.2    Nash, K.3    Lewin, A.S.4    Mandel, R.J.5
  • 46
    • 33846580633 scopus 로고    scopus 로고
    • RNA targeted therapeutics for hematologic malignancies
    • A.M. Gewirtz. RNA targeted therapeutics for hematologic malignancies. Blood Cells Mol Dis. 38:117-119 (2007)
    • (2007) Blood Cells Mol Dis , vol.38 , pp. 117-119
    • Gewirtz, A.M.1
  • 47
    • 33749167739 scopus 로고    scopus 로고
    • RNA interference in pain research
    • T. RohlJ. Kurreck. RNA interference in pain research. J Neurochem. 99:371-380 (2006)
    • (2006) J Neurochem , vol.99 , pp. 371-380
    • Rohl, T.1    Kurreck, J.2
  • 48
    • 0347623204 scopus 로고    scopus 로고
    • Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)
    • S.P. Persengiev, X. Zhu, and M.R. Green. Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs) RNA. 10:12-18 (2004)
    • (2004) RNA , vol.10 , pp. 12-18
    • Persengiev, S.P.1    Zhu, X.2    Green, M.R.3
  • 49
    • 67249122712 scopus 로고    scopus 로고
    • Biological barriers to therapy with antisense and siRNA oligonucleotides
    • R. Juliano, J. Bauman, H. Kang, and X. Ming. Biological barriers to therapy with antisense and siRNA oligonucleotides. Mol Pharm. 6:686-695 (2009)
    • (2009) Mol Pharm , vol.6 , pp. 686-695
    • Juliano, R.1    Bauman, J.2    Kang, H.3    Ming, X.4
  • 50
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • D.M. MosserJ.P. Edwards. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 8:958-969 (2008)
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 51
    • 51049092308 scopus 로고    scopus 로고
    • Factors affecting the clearance and biodistribution of polymeric nanoparticles
    • F. Alexis, E. Pridgen, L.K. Molnar, and O.C. Farokhzad. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm. 5:505-515 (2008)
    • (2008) Mol Pharm , vol.5 , pp. 505-515
    • Alexis, F.1    Pridgen, E.2    Molnar, L.K.3    Farokhzad, O.C.4
  • 54
    • 77951168054 scopus 로고    scopus 로고
    • Breaking down the barriers: siRNA delivery and endosome escape
    • M. DominskaD.M. Dykxhoorn. Breaking down the barriers: siRNA delivery and endosome escape. J Cell Sci. 123:1183-1189 (2010)
    • (2010) J Cell Sci , vol.123 , pp. 1183-1189
    • Dominska, M.1    Dykxhoorn, D.M.2
  • 57
    • 15444373116 scopus 로고    scopus 로고
    • RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
    • B. Urban-Klein, S. Werth, S. Abuharbeid, F. Czubayko, and A. Aigner. RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther. 12:461-466 (2005)
    • (2005) Gene Ther , vol.12 , pp. 461-466
    • Urban-Klein, B.1    Werth, S.2    Abuharbeid, S.3    Czubayko, F.4    Aigner, A.5
  • 59
    • 0041331496 scopus 로고    scopus 로고
    • siRNA function in RNAi: A chemical modification analysis
    • Y.L. ChiuT.M. Rana. siRNA function in RNAi: a chemical modification analysis. RNA. 9:1034-1048 (2003)
    • (2003) RNA , vol.9 , pp. 1034-1048
    • Chiu, Y.L.1    Rana, T.M.2
  • 63
    • 8844262560 scopus 로고    scopus 로고
    • RNA interference and chemically modified small interfering RNAs
    • M. Manoharan. RNA interference and chemically modified small interfering RNAs. Curr Opin Chem Biol. 8:570-579 (2004)
    • (2004) Curr Opin Chem Biol , vol.8 , pp. 570-579
    • Manoharan, M.1
  • 64
    • 12344283777 scopus 로고    scopus 로고
    • Modulation of gene expression by antisense and antigene oligodeoxynucleotides and small interfering RNA
    • R.I. Mahato, K. Cheng, and R.V. Guntaka. Modulation of gene expression by antisense and antigene oligodeoxynucleotides and small interfering RNA. Expert Opin Drug Deliv. 2:3-28 (2005)
    • (2005) Expert Opin Drug Deliv , vol.2 , pp. 3-28
    • Mahato, R.I.1    Cheng, K.2    Guntaka, R.V.3
  • 66
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • A. Khvorova, A. Reynolds, and S.D. Jayasena. Functional siRNAs and miRNAs exhibit strand bias. Cell. 115:209-216 (2003)
    • (2003) Cell , vol.115 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 68
    • 77955817254 scopus 로고    scopus 로고
    • Effective stabilization and delivery of siRNA: Reversible siRNA-phospholipid conjugate in nanosized mixed polymeric micelles
    • T. Musacchio, O. Vaze, G. D'Souza, and V.P. Torchilin. Effective stabilization and delivery of siRNA: reversible siRNA-phospholipid conjugate in nanosized mixed polymeric micelles. Bioconjug Chem. 21:1530-1536 (2010)
    • (2010) Bioconjug Chem , vol.21 , pp. 1530-1536
    • Musacchio, T.1    Vaze, O.2    D'Souza, G.3    Torchilin, V.P.4
  • 69
    • 77957907212 scopus 로고    scopus 로고
    • Synthesis of oligonucleotides carrying amino lipid groups at the 3′-end for RNA interference studies
    • S. Grijalvo, S.M. Ocampo, J.C. Perales, and R. Eritja. Synthesis of oligonucleotides carrying amino lipid groups at the 3′-end for RNA interference studies. J Org Chem. 75:6806-6813 (2010)
    • (2010) J Org Chem , vol.75 , pp. 6806-6813
    • Grijalvo, S.1    Ocampo, S.M.2    Perales, J.C.3    Eritja, R.4
  • 73
    • 0033948268 scopus 로고    scopus 로고
    • Messenger proteins: Homeoproteins, TAT and others
    • A. Prochiantz. Messenger proteins: homeoproteins, TAT and others. Curr Opin Cell Biol. 12:400-406 (2000)
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 400-406
    • Prochiantz, A.1
  • 75
    • 79952201127 scopus 로고    scopus 로고
    • Intracellular delivery of nanoparticles with CPPs
    • R. SawantV. Torchilin. Intracellular delivery of nanoparticles with CPPs. Methods Mol Biol. 683:431-451 (2011)
    • (2011) Methods Mol Biol , vol.683 , pp. 431-451
    • Sawant, R.1    Torchilin, V.2
  • 77
    • 0030904245 scopus 로고    scopus 로고
    • A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
    • E. Vives, P. Brodin, and B. Lebleu. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem. 272:16010-16017 (1997)
    • (1997) J Biol Chem , vol.272 , pp. 16010-16017
    • Vives, E.1    Brodin, P.2    Lebleu, B.3
  • 78
    • 4344651353 scopus 로고    scopus 로고
    • Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells
    • Y.L. Chiu, A. Ali, C.Y. Chu, H. Cao, and T.M. Rana. Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem Biol. 11:1165-1175 (2004)
    • (2004) Chem Biol , vol.11 , pp. 1165-1175
    • Chiu, Y.L.1    Ali, A.2    Chu, C.Y.3    Cao, H.4    Rana, T.M.5
  • 79
    • 66149119384 scopus 로고    scopus 로고
    • TAT peptides mediated small interfering RNA delivery to Huh-7 cells and efficiently inhibited hepatitis C virus RNA replication
    • S. Meng, B. Wei, R. Xu, K. Zhang, L. Wang, R. Zhang, and J. Li. TAT peptides mediated small interfering RNA delivery to Huh-7 cells and efficiently inhibited hepatitis C virus RNA replication. Intervirology. 52:135-140 (2009)
    • (2009) Intervirology , vol.52 , pp. 135-140
    • Meng, S.1    Wei, B.2    Xu, R.3    Zhang, K.4    Wang, L.5    Zhang, R.6    Li, J.7
  • 80
    • 8544231403 scopus 로고    scopus 로고
    • Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation
    • T.J. Davidson, S. Harel, V.A. Arboleda, G.F. Prunell, M.L. Shelanski, L.A. Greene, and C.M. Troy. Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation. J Neurosci. 24:10040-10046 (2004)
    • (2004) J Neurosci , vol.24 , pp. 10040-10046
    • Davidson, T.J.1    Harel, S.2    Arboleda, V.A.3    Prunell, G.F.4    Shelanski, M.L.5    Greene, L.A.6    Troy, C.M.7
  • 81
    • 56749169583 scopus 로고    scopus 로고
    • LHRH receptor-mediated delivery of siRNA using polyelectrolyte complex micelles self-assembled from siRNA-PEG-LHRH conjugate and PEI
    • S.H. Kim, J.H. Jeong, S.H. Lee, S.W. Kim, and T.G. Park. LHRH receptor-mediated delivery of siRNA using polyelectrolyte complex micelles self-assembled from siRNA-PEG-LHRH conjugate and PEI. Bioconjug Chem. 19:2156-2162 (2008)
    • (2008) Bioconjug Chem , vol.19 , pp. 2156-2162
    • Kim, S.H.1    Jeong, J.H.2    Lee, S.H.3    Kim, S.W.4    Park, T.G.5
  • 82
    • 21044445774 scopus 로고    scopus 로고
    • Smart polyion complex micelles for targeted intracellular delivery of PEGylated antisense oligonucleotides containing acid-labile linkages
    • M. Oishi, F. Nagatsugi, S. Sasaki, Y. Nagasaki, and K. Kataoka. Smart polyion complex micelles for targeted intracellular delivery of PEGylated antisense oligonucleotides containing acid-labile linkages. Chembiochem. 6:718-725 (2005)
    • (2005) Chembiochem , vol.6 , pp. 718-725
    • Oishi, M.1    Nagatsugi, F.2    Sasaki, S.3    Nagasaki, Y.4    Kataoka, K.5
  • 83
    • 77953287100 scopus 로고    scopus 로고
    • Gene silencing efficiency of siRNA-PEG conjugates: Effect of PEGylation site and PEG molecular weight
    • S. Jung, S.H. Lee, H. Mok, H.J. Chung, and T.G. Park. Gene silencing efficiency of siRNA-PEG conjugates: effect of PEGylation site and PEG molecular weight. J Control Release. 144:306-313 (2010)
    • (2010) J Control Release , vol.144 , pp. 306-313
    • Jung, S.1    Lee, S.H.2    Mok, H.3    Chung, H.J.4    Park, T.G.5
  • 84
    • 84857429719 scopus 로고    scopus 로고
    • Di- and Triblock siRNA-PEG Copolymers: PEG Density Effect of Polyelectrolyte Complexes on Cellular Uptake and Gene Silencing Efficiency
    • S.H. Lee, H. Mok, and T.G. Park. Di- and Triblock siRNA-PEG Copolymers: PEG Density Effect of Polyelectrolyte Complexes on Cellular Uptake and Gene Silencing Efficiency. Macromol Biosci (2010)
    • (2010) Macromol Biosci
    • Lee, S.H.1    Mok, H.2    Park, T.G.3
  • 85
    • 76849103897 scopus 로고    scopus 로고
    • Multifunctional siRNA delivery system: Polyelectrolyte complex micelles of six-arm PEG conjugate of siRNA and cell penetrating peptide with crosslinked fusogenic peptide
    • S.W. Choi, S.H. Lee, H. Mok, and T.G. Park. Multifunctional siRNA delivery system: polyelectrolyte complex micelles of six-arm PEG conjugate of siRNA and cell penetrating peptide with crosslinked fusogenic peptide. Biotechnol Prog. 26:57-63 (2010)
    • (2010) Biotechnol Prog , vol.26 , pp. 57-63
    • Choi, S.W.1    Lee, S.H.2    Mok, H.3    Park, T.G.4
  • 86
    • 34247153120 scopus 로고    scopus 로고
    • Intracellular siRNA delivery system using polyelectrolyte complex micelles prepared from VEGF siRNA-PEG conjugate and cationic fusogenic peptide
    • S.H. Lee, S.H. Kim, and T.G. Park. Intracellular siRNA delivery system using polyelectrolyte complex micelles prepared from VEGF siRNA-PEG conjugate and cationic fusogenic peptide. Biochem Biophys Res Commun. 357:511-516 (2007)
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 511-516
    • Lee, S.H.1    Kim, S.H.2    Park, T.G.3
  • 87
    • 78649260473 scopus 로고    scopus 로고
    • Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation
    • L. ZhuR.I. Mahato. Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation. Bioconjug Chem. 21:2119-2127 (2010)
    • (2010) Bioconjug Chem , vol.21 , pp. 2119-2127
    • Zhu, L.1    Mahato, R.I.2
  • 88
    • 13644254495 scopus 로고    scopus 로고
    • Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells
    • M. Oishi, Y. Nagasaki, K. Itaka, N. Nishiyama, and K. Kataoka. Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells. J Am Chem Soc. 127:1624-1625 (2005)
    • (2005) J Am Chem Soc , vol.127 , pp. 1624-1625
    • Oishi, M.1    Nagasaki, Y.2    Itaka, K.3    Nishiyama, N.4    Kataoka, K.5
  • 89
    • 77049109902 scopus 로고    scopus 로고
    • Intracellular trafficking and unpacking of siRNA/quantum dot-PEI complexes modified with and without cell penetrating peptide: Confocal and flow cytometric FRET analysis
    • H. Lee, I.K. Kim, and T.G. Park. Intracellular trafficking and unpacking of siRNA/quantum dot-PEI complexes modified with and without cell penetrating peptide: confocal and flow cytometric FRET analysis. Bioconjug Chem. 21:289-295 (2010)
    • (2010) Bioconjug Chem , vol.21 , pp. 289-295
    • Lee, H.1    Kim, I.K.2    Park, T.G.3
  • 90
    • 78349306448 scopus 로고    scopus 로고
    • Surface functionalized hollow manganese oxide nanoparticles for cancer targeted siRNA delivery and magnetic resonance imaging
    • K.H. Bae, K. Lee, C. Kim, and T.G. Park. Surface functionalized hollow manganese oxide nanoparticles for cancer targeted siRNA delivery and magnetic resonance imaging. Biomaterials. 32:176-184 (2011)
    • (2011) Biomaterials , vol.32 , pp. 176-184
    • Bae, K.H.1    Lee, K.2    Kim, C.3    Park, T.G.4
  • 92
    • 78650883368 scopus 로고    scopus 로고
    • Multifunctional nanomedicine platform for cancer specific delivery of siRNA by superparamagnetic iron oxide nanoparticles-dendrimer complexes
    • O. Taratula, O. Garbuzenko, R. Savla, Y.A. Wang, H. He, and T. Minko. Multifunctional nanomedicine platform for cancer specific delivery of siRNA by superparamagnetic iron oxide nanoparticles-dendrimer complexes. Curr Drug Deliv. 8:59-69 (2011)
    • (2011) Curr Drug Deliv , vol.8 , pp. 59-69
    • Taratula, O.1    Garbuzenko, O.2    Savla, R.3    Wang, Y.A.4    He, H.5    Minko, T.6
  • 95
    • 33646144003 scopus 로고    scopus 로고
    • siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene
    • C. Zhang, N. Tang, X. Liu, W. Liang, W. Xu, and V.P. Torchilin. siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene. J Control Release. 112:229-239 (2006)
    • (2006) J Control Release , vol.112 , pp. 229-239
    • Zhang, C.1    Tang, N.2    Liu, X.3    Liang, W.4    Xu, W.5    Torchilin, V.P.6
  • 96
    • 77950571073 scopus 로고    scopus 로고
    • pH-responsive polymeric sirna carriers sensitize multidrug resistant ovarian cancer cells to doxorubicin via knockdown of polo-like kinase 1
    • D.S. Benoit, S.M. Henry, A.D. Shubin, A.S. Hoffman, and P.S. Stayton. pH-responsive polymeric sirna carriers sensitize multidrug resistant ovarian cancer cells to doxorubicin via knockdown of polo-like kinase 1. Mol Pharm. 7:442-455 (2010)
    • (2010) Mol Pharm , vol.7 , pp. 442-455
    • Benoit, D.S.1    Henry, S.M.2    Shubin, A.D.3    Hoffman, A.S.4    Stayton, P.S.5
  • 99
    • 77956633797 scopus 로고    scopus 로고
    • In vivo delivery of small interfering RNA to tumors and their vasculature by novel dendritic nanocarriers
    • P. Ofek, W. Fischer, M. Calderon, R. Haag, and R. Satchi-Fainaro. In vivo delivery of small interfering RNA to tumors and their vasculature by novel dendritic nanocarriers. FASEB J. 24:3122-3134 (2010)
    • (2010) FASEB J , vol.24 , pp. 3122-3134
    • Ofek, P.1    Fischer, W.2    Calderon, M.3    Haag, R.4    Satchi-Fainaro, R.5
  • 100
    • 64149113037 scopus 로고    scopus 로고
    • Internally cationic polyamidoamine PAMAM-OH dendrimers for siRNA delivery: Effect of the degree of quaternization and cancer targeting
    • M.L. Patil, M. Zhang, O. Taratula, O.B. Garbuzenko, H. He, and T. Minko. Internally cationic polyamidoamine PAMAM-OH dendrimers for siRNA delivery: effect of the degree of quaternization and cancer targeting. Biomacromolecules. 10:258-266 (2009)
    • (2009) Biomacromolecules , vol.10 , pp. 258-266
    • Patil, M.L.1    Zhang, M.2    Taratula, O.3    Garbuzenko, O.B.4    He, H.5    Minko, T.6
  • 102
    • 0242414440 scopus 로고    scopus 로고
    • Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes
    • N.D. Sonawane, F.C. Szoka, Jr., and A.S. Verkman. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem. 278:44826-44831 (2003)
    • (2003) J Biol Chem , vol.278 , pp. 44826-44831
    • Sonawane, N.D.1    Szoka Jr., F.C.2    Verkman, A.S.3
  • 104
    • 24744437125 scopus 로고    scopus 로고
    • Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing
    • N.W. Kam, Z. Liu, and H. Dai. Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. J Am Chem Soc. 127:12492-12493 (2005)
    • (2005) J Am Chem Soc , vol.127 , pp. 12492-12493
    • Kam, N.W.1    Liu, Z.2    Dai, H.3
  • 105
    • 34247582332 scopus 로고    scopus 로고
    • siRNA delivery into human T cells and primary cells with carbon-nanotube transporters
    • Z. Liu, M. Winters, M. Holodniy, and H. Dai. siRNA delivery into human T cells and primary cells with carbon-nanotube transporters. Angew Chem Int Ed Engl. 46:2023-2027 (2007)
    • (2007) Angew Chem Int Ed Engl , vol.46 , pp. 2023-2027
    • Liu, Z.1    Winters, M.2    Holodniy, M.3    Dai, H.4
  • 108
    • 77956271401 scopus 로고    scopus 로고
    • Efficient siRNA delivery based on PEGylated and partially quaternized polyamine nanogels: Enhanced gene silencing activity by the cooperative effect of tertiary and quaternary amino groups in the core
    • A. Tamura, M. Oishi, and Y. Nagasaki. Efficient siRNA delivery based on PEGylated and partially quaternized polyamine nanogels: enhanced gene silencing activity by the cooperative effect of tertiary and quaternary amino groups in the core. J Control Release. 146:378-387 (2010)
    • (2010) J Control Release , vol.146 , pp. 378-387
    • Tamura, A.1    Oishi, M.2    Nagasaki, Y.3
  • 109
    • 34248544999 scopus 로고    scopus 로고
    • Target-specific intracellular delivery of siRNA using degradable hyaluronic acid nanogels
    • H. Lee, H. Mok, S. Lee, Y.K. Oh, and T.G. Park. Target-specific intracellular delivery of siRNA using degradable hyaluronic acid nanogels. J Control Release. 119:245-252 (2007)
    • (2007) J Control Release , vol.119 , pp. 245-252
    • Lee, H.1    Mok, H.2    Lee, S.3    Oh, Y.K.4    Park, T.G.5
  • 110
    • 42549146715 scopus 로고    scopus 로고
    • Size Controlled Synthesis of Monodispersed, Core/Shell Nanogels
    • W.H. BlackburnL.A. Lyon. Size Controlled Synthesis of Monodispersed, Core/Shell Nanogels. Colloid Polym Sci. 286:563-569 (2008)
    • (2008) Colloid Polym Sci , vol.286 , pp. 563-569
    • Blackburn, W.H.1    Lyon, L.A.2
  • 111
    • 33746293279 scopus 로고    scopus 로고
    • Mechanics versus thermodynamics: Swelling in multiple-temperature- sensitive core-shell microgels
    • I. Berndt, C. Popescu, F.J. Wortmann, and W. Richtering. Mechanics versus thermodynamics: swelling in multiple-temperature-sensitive core-shell microgels. Angew Chem Int Ed Engl. 45:1081-1085 (2006)
    • (2006) Angew Chem Int Ed Engl , vol.45 , pp. 1081-1085
    • Berndt, I.1    Popescu, C.2    Wortmann, F.J.3    Richtering, W.4
  • 112
    • 77954314924 scopus 로고    scopus 로고
    • Prolonged gene silencing by combining siRNA nanogels and photochemical internalization
    • K. Raemdonck, B. Naeye, A. Hogset, J. Demeester, and S.C. De Smedt. Prolonged gene silencing by combining siRNA nanogels and photochemical internalization. J Control Release. 145:281-288 (2010)
    • (2010) J Control Release , vol.145 , pp. 281-288
    • Raemdonck, K.1    Naeye, B.2    Hogset, A.3    Demeester, J.4    De Smedt, S.C.5
  • 116
    • 0036784335 scopus 로고    scopus 로고
    • Translocation of liposomes into cancer cells by cell-penetrating peptides penetratin and tat: A kinetic and efficacy study
    • Y.L. Tseng, J.J. Liu, and R.L. Hong. Translocation of liposomes into cancer cells by cell-penetrating peptides penetratin and tat: a kinetic and efficacy study. Mol Pharmacol. 62:864-872 (2002)
    • (2002) Mol Pharmacol , vol.62 , pp. 864-872
    • Tseng, Y.L.1    Liu, J.J.2    Hong, R.L.3
  • 117
    • 40449083756 scopus 로고    scopus 로고
    • Targeted delivery of small interfering RNA: Approaching effective cancer therapies
    • K.F. PirolloE.H. Chang. Targeted delivery of small interfering RNA: approaching effective cancer therapies. Cancer Res. 68:1247-1250 (2008)
    • (2008) Cancer Res , vol.68 , pp. 1247-1250
    • Pirollo, K.F.1    Chang, E.H.2
  • 118
    • 33645573205 scopus 로고    scopus 로고
    • Cell penetrating peptides enhance intracellular translocation and function of siRNA encapsulated in Pegylated liposomes
    • W. Wang, N. Tang, C.L. Zhang, X.J. Liu, H. Hu, Z.X. Zhang, and W. Liang. [Cell penetrating peptides enhance intracellular translocation and function of siRNA encapsulated in Pegylated liposomes]. Yao Xue Xue Bao. 41:142-148 (2006)
    • (2006) Yao Xue Xue Bao , vol.41 , pp. 142-148
    • Wang, W.1    Tang, N.2    Zhang, C.L.3    Liu, X.J.4    Hu, H.5    Zhang, Z.X.6    Liang, W.7
  • 120
    • 52049117189 scopus 로고    scopus 로고
    • Evolution of phage display: From bioactive peptides to bioselective nanomaterials
    • V. Petrenko. Evolution of phage display: from bioactive peptides to bioselective nanomaterials. Expert Opin Drug Deliv. 5:825-836 (2008)
    • (2008) Expert Opin Drug Deliv , vol.5 , pp. 825-836
    • Petrenko, V.1
  • 123
    • 82055164757 scopus 로고    scopus 로고
    • Controlled synthesis of PEI-coated gold nanoparticles using reductive catechol chemistry for siRNA delivery
    • Y. Lee, S.H. Lee, J.S. Kim, A. Maruyama, X. Chen, and T.G. Park. Controlled synthesis of PEI-coated gold nanoparticles using reductive catechol chemistry for siRNA delivery. J Control Release (2010)
    • (2010) J Control Release
    • Lee, Y.1    Lee, S.H.2    Kim, J.S.3    Maruyama, A.4    Chen, X.5    Park, T.G.6
  • 124
    • 67349234877 scopus 로고    scopus 로고
    • Penetration and efficacy of VEGF siRNA using polyelectrolyte complex micelles in a human solid tumor model in-vitro
    • A.M. Al-Abd, S.H. Lee, S.H. Kim, J.H. Cha, T.G. Park, S.J. Lee, and H.J. Kuh. Penetration and efficacy of VEGF siRNA using polyelectrolyte complex micelles in a human solid tumor model in-vitro. J Control Release. 137:130-135 (2009)
    • (2009) J Control Release , vol.137 , pp. 130-135
    • Al-Abd, A.M.1    Lee, S.H.2    Kim, S.H.3    Cha, J.H.4    Park, T.G.5    Lee, S.J.6    Kuh, H.J.7
  • 125
    • 74849097084 scopus 로고    scopus 로고
    • Co-delivery of siRNA and paclitaxel into cancer cells by biodegradable cationic micelles based on PDMAEMA-PCL-PDMAEMA triblock copolymers
    • C. Zhu, S. Jung, S. Luo, F. Meng, X. Zhu, T.G. Park, and Z. Zhong. Co-delivery of siRNA and paclitaxel into cancer cells by biodegradable cationic micelles based on PDMAEMA-PCL-PDMAEMA triblock copolymers. Biomaterials. 31:2408-2416 (2010)
    • (2010) Biomaterials , vol.31 , pp. 2408-2416
    • Zhu, C.1    Jung, S.2    Luo, S.3    Meng, F.4    Zhu, X.5    Park, T.G.6    Zhong, Z.7
  • 128
    • 0036164530 scopus 로고    scopus 로고
    • Vehicles for oligonucleotide delivery to tumours
    • C.R. Dass. Vehicles for oligonucleotide delivery to tumours. J Pharm Pharmacol. 54:3-27 (2002)
    • (2002) J Pharm Pharmacol , vol.54 , pp. 3-27
    • Dass, C.R.1
  • 131
    • 33745770615 scopus 로고    scopus 로고
    • Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation
    • F. Ahmed, R.I. Pakunlu, G. Srinivas, A. Brannan, F. Bates, M.L. Klein, T. Minko, and D.E. Discher. Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation. Mol Pharm. 3:340-350 (2006)
    • (2006) Mol Pharm , vol.3 , pp. 340-350
    • Ahmed, F.1    Pakunlu, R.I.2    Srinivas, G.3    Brannan, A.4    Bates, F.5    Klein, M.L.6    Minko, T.7    Discher, D.E.8
  • 132
    • 34848839868 scopus 로고    scopus 로고
    • Micelles of different morphologies - Advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery
    • S. Cai, K. Vijayan, D. Cheng, E.M. Lima, and D.E. Discher. Micelles of different morphologies - advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery. Pharm Res. 24:2099-2109 (2007)
    • (2007) Pharm Res , vol.24 , pp. 2099-2109
    • Cai, S.1    Vijayan, K.2    Cheng, D.3    Lima, E.M.4    Discher, D.E.5
  • 133
    • 78650798166 scopus 로고    scopus 로고
    • Cationic nano-copolymers mediated IKKbeta targeting siRNA to modulate wound healing in a monkey model of glaucoma filtration surgery
    • H. Ye, Y. Qian, M. Lin, Y. Duan, X. Sun, Y. Zhuo, and J. Ge. Cationic nano-copolymers mediated IKKbeta targeting siRNA to modulate wound healing in a monkey model of glaucoma filtration surgery. Mol Vis. 16:2502-2510 (2010)
    • (2010) Mol Vis , vol.16 , pp. 2502-2510
    • Ye, H.1    Qian, Y.2    Lin, M.3    Duan, Y.4    Sun, X.5    Zhuo, Y.6    Ge, J.7
  • 134
    • 77955842890 scopus 로고    scopus 로고
    • Inhibition of experimental choroidal neovascularization in mice by anti-VEGFA/VEGFR2 or non-specific siRNA
    • L. Gu, H. Chen, J. Tuo, X. Gao, and L. Chen. Inhibition of experimental choroidal neovascularization in mice by anti-VEGFA/VEGFR2 or non-specific siRNA. Exp Eye Res. 91:433-439 (2010)
    • (2010) Exp Eye Res , vol.91 , pp. 433-439
    • Gu, L.1    Chen, H.2    Tuo, J.3    Gao, X.4    Chen, L.5
  • 136
    • 77349107167 scopus 로고    scopus 로고
    • Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain
    • I.D. Kim, C.M. Lim, J.B. Kim, H.Y. Nam, K. Nam, S.W. Kim, J.S. Park, and J.K. Lee. Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain. J Control Release. 142:422-430 (2010)
    • (2010) J Control Release , vol.142 , pp. 422-430
    • Kim, I.D.1    Lim, C.M.2    Kim, J.B.3    Nam, H.Y.4    Nam, K.5    Kim, S.W.6    Park, J.S.7    Lee, J.K.8
  • 138
    • 77954120438 scopus 로고    scopus 로고
    • Efficient gene silencing in lungs and liver using imidazole-modified chitosan as a nanocarrier for small interfering RNA
    • B. Ghosn, A. Singh, M. Li, A.V. Vlassov, C. Burnett, N. Puri, and K. Roy. Efficient gene silencing in lungs and liver using imidazole-modified chitosan as a nanocarrier for small interfering RNA. Oligonucleotides. 20:163-172 (2010)
    • (2010) Oligonucleotides , vol.20 , pp. 163-172
    • Ghosn, B.1    Singh, A.2    Li, M.3    Vlassov, A.V.4    Burnett, C.5    Puri, N.6    Roy, K.7
  • 140
    • 44649114578 scopus 로고    scopus 로고
    • Optical in vivo imaging of electrically mediated delivery of siRNA into muscle for gene function analysis
    • M. GolzioJ. Teissie. Optical in vivo imaging of electrically mediated delivery of siRNA into muscle for gene function analysis. Methods Mol Biol. 423:279-287 (2008)
    • (2008) Methods Mol Biol , vol.423 , pp. 279-287
    • Golzio, M.1    Teissie, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.