Anti-apoptotic cardioprotective effects of SHP-1 gene silencing against ischemia-reperfusion injury: Use of deoxycholic acid-modified low molecular weight polyethyleneimine as a cardiac siRNA-carrier

Journal of Controlled Release

Volumn 168, Issue 2, 2013, Pages 125-134

  Kim, Dongkyu ^a   Hong, Jueun ^a   Moon, Hyung Ho ^a   Nam, Hye Yeong ^b   Mok, Hyejung ^c   Jeong, Ji Hoon ^d   Kim, Sung Wan ^b   Choi, Donghoon ^a   Kim, Sun Hwa ^e  

^a Yonsei University College of Medicine   (South Korea)

^b UNIVERSITY OF UTAH   (United States)

^c Konkuk University   (South Korea)

^d Sungkyunkwan University   (South Korea)

^e Korea Institute of Science and Technology   (South Korea)

Author keywords

Deoxycholic acid; Low molecular weight; Myocardial apoptosis; Myocardial ischemia reperfusion injury; PEI; SHP 1 siRNA

Indexed keywords

DEOXYCHOLIC ACID; LOW MOLECULAR WEIGHT; MYOCARDIAL APOPTOSIS; MYOCARDIAL ISCHEMIA-REPERFUSION INJURIES; SHP-1 SIRNA;

AMINO ACIDS; GENE EXPRESSION; GENE TRANSFER; HEART; MOLECULAR WEIGHT; POLYETHERIMIDES; REPAIR;

CELL DEATH;

DEOXYCHOLIC ACID; POLYETHYLENEIMINE; PROTEIN TYROSINE PHOSPHATASE SHP 1; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; GENE SILENCING; GENE TRANSFER; HEART INFARCTION; HEART MUSCLE CELL; HEART PROTECTION; HYDROPHOBICITY; HYPOXIA; IN VIVO STUDY; MOLECULAR WEIGHT; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; RNA INTERFERENCE; STATIC ELECTRICITY;

ANIMALS; APOPTOSIS; DEOXYCHOLIC ACID; GENE SILENCING; GENETIC THERAPY; MALE; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; POLYETHYLENEIMINE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA, SMALL INTERFERING;

EID: 84876177910     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.02.031     Document Type: Article

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