Overcoming endosomal barrier by amphotericin B-loaded dual pH-responsive PDMA- b-PDPA micelleplexes for siRNA delivery

ACS Nano

Volumn 5, Issue 11, 2011, Pages 9246-9255

  Yu, Haijun ^a   Zou, Yonglong ^a   Wang, Yiguang ^a   Huang, Xiaonan ^a   Huang, Gang ^a   Sumer, Baran D ^a   Boothman, David A ^a   Gao, Jinming ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

amphotericin B; endosomal escape; nonviral nanocarrier; pH responsive micelleplexes; polymeric micelles; siRNA delivery

Indexed keywords

AMPHOTERICIN B; ENDOSOMAL ESCAPE; NONVIRAL; PH-RESPONSIVE; POLYMERIC MICELLE; SIRNA DELIVERY;

BLOCK COPOLYMERS; MICELLES; POLYMERS;

RNA;

AMPHOTERICIN B; DRUG CARRIER; LUCIFERASE; POLY(2 (DIMETHYLAMINO)ETHYL METHACRYLATE) BLOCK POLY(2 (DIISOPROPYLAMINO)ETHYL METHACRYLATE); POLY(2-(DIMETHYLAMINO)ETHYL METHACRYLATE)-BLOCK-POLY(2-(DIISOPROPYLAMINO)ETHYL METHACRYLATE); POLYMETHACRYLIC ACID DERIVATIVE; SMALL INTERFERING RNA;

ARTICLE; CELL MEMBRANE; CHEMICAL PHENOMENA; CHEMISTRY; ENDOSOME; GENE SILENCING; GENETICS; HUMAN; METABOLISM; MICELLE; PH; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

AMPHOTERICIN B; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CELL MEMBRANE; DRUG CARRIERS; ENDOSOMES; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LUCIFERASES; MICELLES; POLYMETHACRYLIC ACIDS; RNA, SMALL INTERFERING;

EID: 81855227156     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn203503h     Document Type: Article

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