Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles

Biomaterials

Volumn 34, Issue 36, 2013, Pages 9220-9226

  Kanazawa, T ^a   Akiyama, F ^a   Kakizaki, S ^a   Takashima, Y ^a   Seta, Y ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Central nerve system; Nano sized micelles; Nose to brain; SiRNA; Tat analog

Indexed keywords

BLOOD-BRAIN BARRIER; CELL-PENETRATING PEPTIDE; CENTRAL NERVE SYSTEM; NOSE-TO-BRAIN; PHARMACEUTICAL FIELDS; SIRNA; SMALL INTERFERING RNA (SIRNA); TAT ANALOG;

DEXTRAN; DRUG PRODUCTS; PEPTIDES; POLYCAPROLACTONE; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; RNA;

FLAVORS;

CELL PENETRATING PEPTIDE; COPOLYMER; DEXTRAN; MACROGOL; POLYCAPROLACTONE; SMALL INTERFERING RNA;

ANIMAL TISSUE; ARTICLE; BRAIN; DRUG DELIVERY SYSTEM; INTRANASAL BRAIN DELIVERY; INTRAVENOUS DRUG DELIVERY; MALE; MICELLE; NONHUMAN; NOSE; NOSE CAVITY; NOSE MUCOSA; NOSE TO BRAIN DELIVERY SYSTEM; OLFACTORY NERVE; PRIORITY JOURNAL; RAT; TRIGEMINAL NERVE;

CENTRAL NERVE SYSTEM; NANO-SIZED MICELLES; NOSE-TO-BRAIN; SIRNA; TAT ANALOG;

ANIMALS; BRAIN; CELL-PENETRATING PEPTIDES; DEXTRANS; FLUORESCENCE; GENE TRANSFER TECHNIQUES; MALE; MICELLES; NANOPARTICLES; NOSE; OLFACTORY BULB; POLYESTERS; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TISSUE DISTRIBUTION; TRIGEMINAL NERVE;

EID: 84883756054     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.08.036     Document Type: Article

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