Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors

Biomaterials

Volumn 35, Issue 27, 2014, Pages 7887-7895

  Oe, Yusuke ^a   Christie, R James ^a   Naito, Mitsuru ^b   Low, Stewart A ^b   Fukushima, Shigeto ^b   Toh, Kazuko ^a   Miura, Yutaka ^a   Matsumoto, Yu ^a   Nishiyama, Nobuhiro ^a,c   Miyata, Kanjiro ^a   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Active targeting; Cholesterol modified siRNA; Cyclic RGD peptide; Polyion complex micelle; SiRNA delivery

Indexed keywords

CARDIOVASCULAR SYSTEM; CELLS; CHOLESTEROL; CROSSLINKING; HYDROPHOBICITY; LIGANDS; PEPTIDES; RNA; STABILIZATION; SULFUR COMPOUNDS; TUMORS;

ACTIVE TARGETING; HYDROPHOBIC INTERACTIONS; NARROW SIZE DISTRIBUTIONS; POLYION COMPLEX MICELLES; RGD PEPTIDE; SIRNA DELIVERY; SMALL INTERFERING RNA (SIRNA); STABILIZATION MECHANISMS;

MICELLES;

1 (3 MERCAPTOPROPYL)AMIDINE; ARGINYLGLYCYLASPARTIC ACID; CHOLESTEROL; COPOLYMER; DEXTRAN SULFATE; DISULFIDE; MACROGOL; POLYLYSINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; AMIDINE; ARGINYL-GLYCYL-ASPARTIC ACID; CROSS LINKING REAGENT; CYCLOPEPTIDE; ION; MACROGOL DERIVATIVE; MICELLE; OLIGOPEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CERVICAL CANCER CELL LINE; CIRCULATION TIME; COMPLEX FORMATION; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DRUG ACCUMULATION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; LIGHT SCATTERING; MICELLE; MICELLIZATION; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PARTICLE SIZE; POLYION COMPLEX MICELLE; PRIORITY JOURNAL; SOLID TUMOR; TUMOR VOLUME; ANIMAL; CHEMISTRY; ENDOCYTOSIS; GENE TRANSFER; HELA CELL LINE; LIGHT; METABOLISM; NEOPLASM; NUDE MOUSE; PATHOLOGY; PROTON NUCLEAR MAGNETIC RESONANCE; RADIATION SCATTERING; SYNTHESIS;

AMIDINES; ANIMALS; CHOLESTEROL; CROSS-LINKING REAGENTS; DISULFIDES; ENDOCYTOSIS; FEMALE; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; IONS; LIGHT; MICE, NUDE; MICELLES; NEOPLASMS; OLIGOPEPTIDES; PEPTIDES, CYCLIC; POLYETHYLENE GLYCOLS; POLYLYSINE; PROTON MAGNETIC RESONANCE SPECTROSCOPY; RNA, SMALL INTERFERING; SCATTERING, RADIATION;

EID: 84903488678     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.05.041     Document Type: Article

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