SiRNA delivery from triblock copolymer micelles with spatially-ordered compartments of PEG shell, siRNA-loaded intermediate layer, and hydrophobic core

Biomaterials

Volumn 35, Issue 15, 2014, Pages 4548-4556

  Kim, Hyun Jin ^a   Miyata, Kanjiro ^b   Nomoto, Takahiro ^a   Zheng, Meng ^b   Kim, Ahram ^a   Liu, Xueying ^b   Cabral, Horacio ^a   Christie, R James ^b   Nishiyama, Nobuhiro ^c   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Hydrophobic interaction; Polyion complex micelle; SiRNA delivery; Triblock copolymer

Indexed keywords

AGGREGATES; AMINO ACIDS; BLOCK COPOLYMERS; CONTROLLED DRUG DELIVERY; ENERGY TRANSFER; FORSTER RESONANCE ENERGY TRANSFER; HYDROPHOBICITY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; RNA; SHELLS (STRUCTURES); TARGETED DRUG DELIVERY;

CONFOCAL LASER SCANNING MICROSCOPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDROPHOBIC INTERACTIONS; INTRACELLULAR TRAFFICKING; NARROW SIZE DISTRIBUTIONS; POLYION COMPLEX MICELLES; SIRNA DELIVERY; SMALL INTERFERING RNA (SIRNA);

MICELLES;

AMIDE; BENZYL DERIVATIVE; COPOLYMER; DIMETHOXY NITROBENZYL ESTER; DRUG VEHICLE; MACROGOL; POLYETHYLENE GLYCOL POLYLYSINE POLY[N [N (2 AMINOETHYL) 2 AMINOETHYL]ASPARTAMIDE] DIMETHOXY NITROBENZYL ESTER; POLYLYSINE; POLY[N [N (2 AMINOETHYL) 2 AMINOETHYL]ASPARTAMIDE]; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CANCER CELL CULTURE; CELL MIGRATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG RELEASE; DRUG UPTAKE; FLOW CYTOMETRY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE DELIVERY SYSTEM; GENE SILENCING; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; MICELLE; PRIORITY JOURNAL;

HYDROPHOBIC INTERACTION; POLYION COMPLEX MICELLE; SIRNA DELIVERY; TRIBLOCK COPOLYMER;

BENZYL COMPOUNDS; HELA CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICELLES; POLYETHYLENE GLYCOLS; POLYLYSINE; PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84896054791     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.02.016     Document Type: Article

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