Development of lipidoid-sirna formulations for systemic delivery to the liver

Molecular Therapy

Volumn 17, Issue 5, 2009, Pages 872-879

  Akinc, Akin ^a   Goldberg, Michael ^b   Qin, June ^a   Dorkin, J Robert ^a   Gamba Vitalo, Christina ^a   Maier, Martin ^a   Jayaprakash, K Narayanannair ^a   Jayaraman, Muthusamy ^a   Rajeev, Kallanthottathil G ^a   Manoharan, Muthiah ^a   Koteliansky, Victor ^a   Röhl, Ingo ^c   Leshchiner, Elizaveta S ^b   Langer, Robert ^b   Anderson, Daniel G ^b  

^a ALNYLAM PHARMACEUTICALS   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Roche Kulmbach GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 7; LIPID; LIPIDOID; MACROGOL; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG STRUCTURE; DRUG TARGETING; GENE DELIVERY SYSTEM; GENE SILENCING; IN VIVO STUDY; LIVER; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY;

ANIMALS; DRUG CARRIERS; FACTOR VII; LIPIDS; LIVER; MICE; MICE, INBRED C57BL; RNA INTERFERENCE; RNA, SMALL INTERFERING;

ANIMALIA; PRIMATES;

EID: 67349183756     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2009.36     Document Type: Article

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