Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles

Journal of Controlled Release

Volumn 178, Issue 1, 2014, Pages 18-24

  Pittella, Frederico ^a,b   Cabral, Horacio ^b   Maeda, Yoshinori ^b   Mi, Peng ^c   Watanabe, Sumiyo ^a   Takemoto, Hiroyasu ^c   Kim, Hyun Jin ^b   Nishiyama, Nobuhiro ^c   Miyata, Kanjiro ^a   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Calcium phosphate; Charge conversional polymer; PEG; siRNA delivery; Spontaneous pancreatic carcinoma; Transgenic mice

Indexed keywords

AMIDES; BIOCOMPATIBILITY; CALCIUM PHOSPHATE; DISEASES; FLUORESCENCE IMAGING; MAMMALS; ONCOLOGY; PLANTS (BOTANY); POLYETHYLENE GLYCOLS; RNA; TUMORS;

HEMATOLOGICAL PARAMETERS; HISTOLOGICAL ANALYSIS; NARROW SIZE DISTRIBUTIONS; PANCREATIC CARCINOMA; SEQUENCE-SPECIFIC MANNER; SIRNA DELIVERY; SMALL INTERFERING RNA (SIRNA); TRANSGENIC MICE;

MICELLES;

CALCIUM PHOSPHATE; HYBRID MICELLE; LUCIFERASE; MACROGOL; NANOCARRIER; NANOPARTICLE; POLYANION; POLYMER; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CANCER THERAPY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG STABILITY; ENDOSOME; FEMALE; FLUORESCENCE IMAGING; GENE SILENCING; HEMATOLOGICAL PARAMETERS; HISTOLOGY; HUMAN; HUMAN CELL; HYBRID; LUCIFERASE ASSAY; MALE; MICELLE; MOUSE; NONHUMAN; PANCREAS TUMOR; PH; PRIORITY JOURNAL; RNA INTERFERENCE; TRANSGENIC MOUSE;

CALCIUM PHOSPHATE; CHARGE-CONVERSIONAL POLYMER; PEG; SIRNA DELIVERY; SPONTANEOUS PANCREATIC CARCINOMA; TRANSGENIC MICE;

ANIMALS; CALCIUM PHOSPHATES; CELL LINE, TUMOR; GENE SILENCING; LUCIFERASES; MALE; MICE; MICE, TRANSGENIC; MICELLES; NANOPARTICLES; PANCREATIC NEOPLASMS; POLYETHYLENE GLYCOLS; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 84893421625     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.01.008     Document Type: Article

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