-
1
-
-
84909545302
-
Chemotherapeutic activity of nucleic acids and high protein diets against the infection caused by the MM virus in mice
-
O'Dell, T.B., Wright, H.N., Bieter, R.N., Chemotherapeutic activity of nucleic acids and high protein diets against the infection caused by the MM virus in mice. J. Pharmacol. Exp. Therap. 107:2 (1953), 232–240.
-
(1953)
J. Pharmacol. Exp. Therap.
, vol.107
, Issue.2
, pp. 232-240
-
-
O'Dell, T.B.1
Wright, H.N.2
Bieter, R.N.3
-
2
-
-
0000520727
-
Virus interference. I. The interferon
-
Isaacs, A., Lindenmann, J., Virus interference. I. The interferon. Proc. R. Soc. Lond. Ser. B Biol. Sci. 147:927 (1957), 258–267.
-
(1957)
Proc. R. Soc. Lond. Ser. B Biol. Sci.
, vol.147
, Issue.927
, pp. 258-267
-
-
Isaacs, A.1
Lindenmann, J.2
-
3
-
-
0001311171
-
Inhibition of virus multiplication by foreign nucleic acid
-
Rotem, Z., Cox, R.A., Isaacs, A., Inhibition of virus multiplication by foreign nucleic acid. Nature 197 (1963), 564–566.
-
(1963)
Nature
, vol.197
, pp. 564-566
-
-
Rotem, Z.1
Cox, R.A.2
Isaacs, A.3
-
4
-
-
0343185886
-
Foreign nucleic acids as the stimulus to make interferon
-
Isaacs, A., Cox, R.A., Rotem, Z., Foreign nucleic acids as the stimulus to make interferon. Lancet 2:7299 (1963), 113–116.
-
(1963)
Lancet
, vol.2
, Issue.7299
, pp. 113-116
-
-
Isaacs, A.1
Cox, R.A.2
Rotem, Z.3
-
5
-
-
0000970577
-
Interferon responses of chick embryo fibroblasts to nucleic acids and related compounds
-
Jensen, K.E., Neal, A.L., Owens, R.E., Warren, J., Interferon responses of chick embryo fibroblasts to nucleic acids and related compounds. Nature 200 (1963), 433–434.
-
(1963)
Nature
, vol.200
, pp. 433-434
-
-
Jensen, K.E.1
Neal, A.L.2
Owens, R.E.3
Warren, J.4
-
6
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
-
Alexopoulou, L., Holt, A.C., Medzhitov, R., Flavell, R.A., Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413:6857 (2001), 732–738.
-
(2001)
Nature
, vol.413
, Issue.6857
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
7
-
-
0036008014
-
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
-
Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., Akira, S., Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3:2 (2002), 196–200.
-
(2002)
Nat. Immunol.
, vol.3
, Issue.2
, pp. 196-200
-
-
Hemmi, H.1
Kaisho, T.2
Takeuchi, O.3
Sato, S.4
Sanjo, H.5
Hoshino, K.6
Horiuchi, T.7
Tomizawa, H.8
Takeda, K.9
Akira, S.10
-
8
-
-
0036088492
-
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
-
Jurk, M., Heil, F., Vollmer, J., Schetter, C., Krieg, A.M., Wagner, H., Lipford, G., Bauer, S., Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol., 3(6), 2002, 499.
-
(2002)
Nat. Immunol.
, vol.3
, Issue.6
, pp. 499
-
-
Jurk, M.1
Heil, F.2
Vollmer, J.3
Schetter, C.4
Krieg, A.M.5
Wagner, H.6
Lipford, G.7
Bauer, S.8
-
9
-
-
0035979192
-
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
-
Bauer, S., Kirschning, C.J., Hacker, H., Redecke, V., Hausmann, S., Akira, S., Wagner, H., Lipford, G.B., Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 98:16 (2001), 9237–9242.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, Issue.16
, pp. 9237-9242
-
-
Bauer, S.1
Kirschning, C.J.2
Hacker, H.3
Redecke, V.4
Hausmann, S.5
Akira, S.6
Wagner, H.7
Lipford, G.B.8
-
10
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., Akira, S., A Toll-like receptor recognizes bacterial DNA. Nature 408:6813 (2000), 740–745.
-
(2000)
Nature
, vol.408
, Issue.6813
, pp. 740-745
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
Matsumoto, M.7
Hoshino, K.8
Wagner, H.9
Takeda, K.10
Akira, S.11
-
11
-
-
0042307304
-
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
-
Diebold, S.S., Montoya, M., Unger, H., Alexopoulou, L., Roy, P., Haswell, L.E., Al-Shamkhani, A., Flavell, R., Borrow, P., Reis e Sousa, C., Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature 424:6946 (2003), 324–328.
-
(2003)
Nature
, vol.424
, Issue.6946
, pp. 324-328
-
-
Diebold, S.S.1
Montoya, M.2
Unger, H.3
Alexopoulou, L.4
Roy, P.5
Haswell, L.E.6
Al-Shamkhani, A.7
Flavell, R.8
Borrow, P.9
Reis e Sousa, C.10
-
12
-
-
30444450839
-
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
-
Stetson, D.B., Medzhitov, R., Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24:1 (2006), 93–103.
-
(2006)
Immunity
, vol.24
, Issue.1
, pp. 93-103
-
-
Stetson, D.B.1
Medzhitov, R.2
-
13
-
-
29244471275
-
A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
-
Ishii, K.J., Coban, C., Kato, H., Takahashi, K., Torii, Y., Takeshita, F., Ludwig, H., Sutter, G., Suzuki, K., Hemmi, H., Sato, S., Yamamoto, M., Uematsu, S., Kawai, T., Takeuchi, O., Akira, S., A toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 7:1 (2006), 40–48.
-
(2006)
Nat. Immunol.
, vol.7
, Issue.1
, pp. 40-48
-
-
Ishii, K.J.1
Coban, C.2
Kato, H.3
Takahashi, K.4
Torii, Y.5
Takeshita, F.6
Ludwig, H.7
Sutter, G.8
Suzuki, K.9
Hemmi, H.10
Sato, S.11
Yamamoto, M.12
Uematsu, S.13
Kawai, T.14
Takeuchi, O.15
Akira, S.16
-
14
-
-
3242813113
-
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
-
Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., Fujita, T., The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5:7 (2004), 730–737.
-
(2004)
Nat. Immunol.
, vol.5
, Issue.7
, pp. 730-737
-
-
Yoneyama, M.1
Kikuchi, M.2
Natsukawa, T.3
Shinobu, N.4
Imaizumi, T.5
Miyagishi, M.6
Taira, K.7
Akira, S.8
Fujita, T.9
-
15
-
-
33744791510
-
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
-
Gitlin, L., Barchet, W., Gilfillan, S., Cella, M., Beutler, B., Flavell, R.A., Diamond, M.S., Colonna, M., Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc. Natl. Acad. Sci. USA 103:22 (2006), 8459–8464.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, Issue.22
, pp. 8459-8464
-
-
Gitlin, L.1
Barchet, W.2
Gilfillan, S.3
Cella, M.4
Beutler, B.5
Flavell, R.A.6
Diamond, M.S.7
Colonna, M.8
-
16
-
-
33646342149
-
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
-
Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K.J., Yamaguchi, O., Otsu, K., Tsujimura, T., Koh, C.S., Reis e Sousa, C., Matsuura, Y., Fujita, T., Akira, S., Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441:7089 (2006), 101–105.
-
(2006)
Nature
, vol.441
, Issue.7089
, pp. 101-105
-
-
Kato, H.1
Takeuchi, O.2
Sato, S.3
Yoneyama, M.4
Yamamoto, M.5
Matsui, K.6
Uematsu, S.7
Jung, A.8
Kawai, T.9
Ishii, K.J.10
Yamaguchi, O.11
Otsu, K.12
Tsujimura, T.13
Koh, C.S.14
Reis e Sousa, C.15
Matsuura, Y.16
Fujita, T.17
Akira, S.18
-
17
-
-
23844438864
-
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
-
Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K., Foy, E., Loo, Y.M., Gale, M. Jr., Akira, S., Yonehara, S., Kato, A., Fujita, T., Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J. Immunol. 175:5 (2005), 2851–2858.
-
(2005)
J. Immunol.
, vol.175
, Issue.5
, pp. 2851-2858
-
-
Yoneyama, M.1
Kikuchi, M.2
Matsumoto, K.3
Imaizumi, T.4
Miyagishi, M.5
Taira, K.6
Foy, E.7
Loo, Y.M.8
Gale, M.9
Akira, S.10
Yonehara, S.11
Kato, A.12
Fujita, T.13
-
18
-
-
10344259136
-
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter
-
Andrejeva, J., Childs, K.S., Young, D.F., Carlos, T.S., Stock, N., Goodbourn, S., Randall, R.E., The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc. Natl. Acad. Sci. USA 101:49 (2004), 17264–17269.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.49
, pp. 17264-17269
-
-
Andrejeva, J.1
Childs, K.S.2
Young, D.F.3
Carlos, T.S.4
Stock, N.5
Goodbourn, S.6
Randall, R.E.7
-
19
-
-
84873711885
-
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
-
Sun, L., Wu, J., Du, F., Chen, X., Chen, Z.J., Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339:6121 (2013), 786–791.
-
(2013)
Science
, vol.339
, Issue.6121
, pp. 786-791
-
-
Sun, L.1
Wu, J.2
Du, F.3
Chen, X.4
Chen, Z.J.5
-
20
-
-
63649145255
-
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
-
Fernandes-Alnemri, T., Yu, J.W., Datta, P., Wu, J., Alnemri, E.S., AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458:7237 (2009), 509–513.
-
(2009)
Nature
, vol.458
, Issue.7237
, pp. 509-513
-
-
Fernandes-Alnemri, T.1
Yu, J.W.2
Datta, P.3
Wu, J.4
Alnemri, E.S.5
-
21
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
-
Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D.R., Latz, E., Fitzgerald, K.A., AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458:7237 (2009), 514–518.
-
(2009)
Nature
, vol.458
, Issue.7237
, pp. 514-518
-
-
Hornung, V.1
Ablasser, A.2
Charrel-Dennis, M.3
Bauernfeind, F.4
Horvath, G.5
Caffrey, D.R.6
Latz, E.7
Fitzgerald, K.A.8
-
22
-
-
60749136484
-
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
-
Burckstummer, T., Baumann, C., Bluml, S., Dixit, E., Durnberger, G., Jahn, H., Planyavsky, M., Bilban, M., Colinge, J., Bennett, K.L., Superti-Furga, G., An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10:3 (2009), 266–272.
-
(2009)
Nat. Immunol.
, vol.10
, Issue.3
, pp. 266-272
-
-
Burckstummer, T.1
Baumann, C.2
Bluml, S.3
Dixit, E.4
Durnberger, G.5
Jahn, H.6
Planyavsky, M.7
Bilban, M.8
Colinge, J.9
Bennett, K.L.10
Superti-Furga, G.11
-
23
-
-
60749104535
-
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
-
Roberts, T.L., Idris, A., Dunn, J.A., Kelly, G.M., Burnton, C.M., Hodgson, S., Hardy, L.L., Garceau, V., Sweet, M.J., Ross, I.L., Hume, D.A., Stacey, K.J., HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 323:5917 (2009), 1057–1060.
-
(2009)
Science
, vol.323
, Issue.5917
, pp. 1057-1060
-
-
Roberts, T.L.1
Idris, A.2
Dunn, J.A.3
Kelly, G.M.4
Burnton, C.M.5
Hodgson, S.6
Hardy, L.L.7
Garceau, V.8
Sweet, M.J.9
Ross, I.L.10
Hume, D.A.11
Stacey, K.J.12
-
24
-
-
84901038448
-
Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1beta production
-
Roth, S., Rottach, A., Lotz-Havla, A.S., Laux, V., Muschaweckh, A., Gersting, S.W., Muntau, A.C., Hopfner, K.P., Jin, L., Vanness, K., Petrini, J.H., Drexler, I., Leonhardt, H., Ruland, J., Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1beta production. Nat. Immunol. 15:6 (2014), 538–545.
-
(2014)
Nat. Immunol.
, vol.15
, Issue.6
, pp. 538-545
-
-
Roth, S.1
Rottach, A.2
Lotz-Havla, A.S.3
Laux, V.4
Muschaweckh, A.5
Gersting, S.W.6
Muntau, A.C.7
Hopfner, K.P.8
Jin, L.9
Vanness, K.10
Petrini, J.H.11
Drexler, I.12
Leonhardt, H.13
Ruland, J.14
-
25
-
-
74049126045
-
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production
-
Poeck, H., Bscheider, M., Gross, O., Finger, K., Roth, S., Rebsamen, M., Hannesschlager, N., Schlee, M., Rothenfusser, S., Barchet, W., Kato, H., Akira, S., Inoue, S., Endres, S., Peschel, C., Hartmann, G., Hornung, V., Ruland, J., Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat. Immunol. 11:1 (2010), 63–69.
-
(2010)
Nat. Immunol.
, vol.11
, Issue.1
, pp. 63-69
-
-
Poeck, H.1
Bscheider, M.2
Gross, O.3
Finger, K.4
Roth, S.5
Rebsamen, M.6
Hannesschlager, N.7
Schlee, M.8
Rothenfusser, S.9
Barchet, W.10
Kato, H.11
Akira, S.12
Inoue, S.13
Endres, S.14
Peschel, C.15
Hartmann, G.16
Hornung, V.17
Ruland, J.18
-
26
-
-
77958140656
-
IFI16 is an innate immune sensor for intracellular DNA
-
Unterholzner, L., Keating, S.E., Baran, M., Horan, K.A., Jensen, S.B., Sharma, S., Sirois, C.M., Jin, T., Latz, E., Xiao, T.S., Fitzgerald, K.A., Paludan, S.R., Bowie, A.G., IFI16 is an innate immune sensor for intracellular DNA. Nat. Immunol. 11:11 (2010), 997–1004.
-
(2010)
Nat. Immunol.
, vol.11
, Issue.11
, pp. 997-1004
-
-
Unterholzner, L.1
Keating, S.E.2
Baran, M.3
Horan, K.A.4
Jensen, S.B.5
Sharma, S.6
Sirois, C.M.7
Jin, T.8
Latz, E.9
Xiao, T.S.10
Fitzgerald, K.A.11
Paludan, S.R.12
Bowie, A.G.13
-
27
-
-
70349459734
-
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
-
Ablasser, A., Bauernfeind, F., Hartmann, G., Latz, E., Fitzgerald, K.A., Hornung, V., RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat. Immunol. 10:10 (2009), 1065–1072.
-
(2009)
Nat. Immunol.
, vol.10
, Issue.10
, pp. 1065-1072
-
-
Ablasser, A.1
Bauernfeind, F.2
Hartmann, G.3
Latz, E.4
Fitzgerald, K.A.5
Hornung, V.6
-
28
-
-
68049092912
-
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
-
Chiu, Y.H., Macmillan, J.B., Chen, Z.J., RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138:3 (2009), 576–591.
-
(2009)
Cell
, vol.138
, Issue.3
, pp. 576-591
-
-
Chiu, Y.H.1
Macmillan, J.B.2
Chen, Z.J.3
-
29
-
-
84964342391
-
Recognition of endogenous nucleic acids by the innate immune system
-
Roers, A., Hiller, B., Hornung, V., Recognition of endogenous nucleic acids by the innate immune system. Immunity 44:4 (2016), 739–754.
-
(2016)
Immunity
, vol.44
, Issue.4
, pp. 739-754
-
-
Roers, A.1
Hiller, B.2
Hornung, V.3
-
30
-
-
79956300649
-
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
-
Kawai, T., Akira, S., Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34:5 (2011), 637–650.
-
(2011)
Immunity
, vol.34
, Issue.5
, pp. 637-650
-
-
Kawai, T.1
Akira, S.2
-
31
-
-
84921047960
-
Viral RNA detection by RIG-I-like receptors
-
Yoneyama, M., Onomoto, K., Jogi, M., Akaboshi, T., Fujita, T., Viral RNA detection by RIG-I-like receptors. Curr. Opin. Immunol. 32 (2015), 48–53.
-
(2015)
Curr. Opin. Immunol.
, vol.32
, pp. 48-53
-
-
Yoneyama, M.1
Onomoto, K.2
Jogi, M.3
Akaboshi, T.4
Fujita, T.5
-
32
-
-
84879385334
-
CGAS produces a 2′–5′-linked cyclic dinucleotide second messenger that activates STING
-
Ablasser, A., Goldeck, M., Cavlar, T., Deimling, T., Witte, G., Rohl, I., Hopfner, K.P., Ludwig, J., Hornung, V., CGAS produces a 2′–5′-linked cyclic dinucleotide second messenger that activates STING. Nature 498:7454 (2013), 380–384.
-
(2013)
Nature
, vol.498
, Issue.7454
, pp. 380-384
-
-
Ablasser, A.1
Goldeck, M.2
Cavlar, T.3
Deimling, T.4
Witte, G.5
Rohl, I.6
Hopfner, K.P.7
Ludwig, J.8
Hornung, V.9
-
33
-
-
84878309796
-
Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
-
Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B.L., Zillinger, T., Serganov, A.A., Liu, Y., Jones, R.A., Hartmann, G., Tuschl, T., Patel, D.J., Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell 153:5 (2013), 1094–1107.
-
(2013)
Cell
, vol.153
, Issue.5
, pp. 1094-1107
-
-
Gao, P.1
Ascano, M.2
Wu, Y.3
Barchet, W.4
Gaffney, B.L.5
Zillinger, T.6
Serganov, A.A.7
Liu, Y.8
Jones, R.A.9
Hartmann, G.10
Tuschl, T.11
Patel, D.J.12
-
34
-
-
84862976171
-
Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16
-
Li, T., Diner, B.A., Chen, J., Cristea, I.M., Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16. Proc. Natl. Acad. Sci. USA 109:26 (2012), 10558–10563.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, Issue.26
, pp. 10558-10563
-
-
Li, T.1
Diner, B.A.2
Chen, J.3
Cristea, I.M.4
-
35
-
-
84878572947
-
The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
-
Diner, E.J., Burdette, D.L., Wilson, S.C., Monroe, K.M., Kellenberger, C.A., Hyodo, M., Hayakawa, Y., Hammond, M.C., Vance, R.E., The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep. 3:5 (2013), 1355–1361.
-
(2013)
Cell Rep.
, vol.3
, Issue.5
, pp. 1355-1361
-
-
Diner, E.J.1
Burdette, D.L.2
Wilson, S.C.3
Monroe, K.M.4
Kellenberger, C.A.5
Hyodo, M.6
Hayakawa, Y.7
Hammond, M.C.8
Vance, R.E.9
-
36
-
-
84873724533
-
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
-
Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C., Chen, Z.J., Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339:6121 (2013), 826–830.
-
(2013)
Science
, vol.339
, Issue.6121
, pp. 826-830
-
-
Wu, J.1
Sun, L.2
Chen, X.3
Du, F.4
Shi, H.5
Chen, C.6
Chen, Z.J.7
-
37
-
-
84933514711
-
Activation and regulation of DNA-driven immune responses
-
Paludan, S.R., Activation and regulation of DNA-driven immune responses. Microbiol. Mol. Biol. Rev. 79:2 (2015), 225–241.
-
(2015)
Microbiol. Mol. Biol. Rev.
, vol.79
, Issue.2
, pp. 225-241
-
-
Paludan, S.R.1
-
38
-
-
79956061094
-
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
-
Kerur, N., Veettil, M.V., Sharma-Walia, N., Bottero, V., Sadagopan, S., Otageri, P., Chandran, B., IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 9:5 (2011), 363–375.
-
(2011)
Cell Host Microbe
, vol.9
, Issue.5
, pp. 363-375
-
-
Kerur, N.1
Veettil, M.V.2
Sharma-Walia, N.3
Bottero, V.4
Sadagopan, S.5
Otageri, P.6
Chandran, B.7
-
39
-
-
84905375825
-
Listeria monocytogenes induces IFNbeta expression through an IFI16-, cGAS- and STING-dependent pathway
-
Hansen, K., Prabakaran, T., Laustsen, A., Jorgensen, S.E., Rahbaek, S.H., Jensen, S.B., Nielsen, R., Leber, J.H., Decker, T., Horan, K.A., Jakobsen, M.R., Paludan, S.R., Listeria monocytogenes induces IFNbeta expression through an IFI16-, cGAS- and STING-dependent pathway. EMBO J. 33:15 (2014), 1654–1666.
-
(2014)
EMBO J.
, vol.33
, Issue.15
, pp. 1654-1666
-
-
Hansen, K.1
Prabakaran, T.2
Laustsen, A.3
Jorgensen, S.E.4
Rahbaek, S.H.5
Jensen, S.B.6
Nielsen, R.7
Leber, J.H.8
Decker, T.9
Horan, K.A.10
Jakobsen, M.R.11
Paludan, S.R.12
-
40
-
-
84888002403
-
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
-
Jakobsen, M.R., Bak, R.O., Andersen, A., Berg, R.K., Jensen, S.B., Tengchuan, J., Laustsen, A., Hansen, K., Ostergaard, L., Fitzgerald, K.A., Xiao, T.S., Mikkelsen, J.G., Mogensen, T.H., Paludan, S.R., IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. Proc. Natl. Acad. Sci. USA 110:48 (2013), E4571–E4580.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, Issue.48
, pp. E4571-E4580
-
-
Jakobsen, M.R.1
Bak, R.O.2
Andersen, A.3
Berg, R.K.4
Jensen, S.B.5
Tengchuan, J.6
Laustsen, A.7
Hansen, K.8
Ostergaard, L.9
Fitzgerald, K.A.10
Xiao, T.S.11
Mikkelsen, J.G.12
Mogensen, T.H.13
Paludan, S.R.14
-
41
-
-
84868095535
-
Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein
-
Orzalli, M.H., DeLuca, N.A., Knipe, D.M., Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein. Proc. Natl. Acad. Sci. USA 109:44 (2012), E3008–E3017.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, Issue.44
, pp. E3008-E3017
-
-
Orzalli, M.H.1
DeLuca, N.A.2
Knipe, D.M.3
-
42
-
-
84997751528
-
The AIM2-like receptors are dispensable for the interferon response to intracellular DNA
-
Gray, E.E., Winship, D., Snyder, J.M., Child, S.J., Geballe, A.P., Stetson, D.B., The AIM2-like receptors are dispensable for the interferon response to intracellular DNA. Immunity 45:2 (2016), 255–266.
-
(2016)
Immunity
, vol.45
, Issue.2
, pp. 255-266
-
-
Gray, E.E.1
Winship, D.2
Snyder, J.M.3
Child, S.J.4
Geballe, A.P.5
Stetson, D.B.6
-
43
-
-
84878190840
-
Immune sensing of DNA
-
Paludan, S.R., Bowie, A.G., Immune sensing of DNA. Immunity 38:5 (2013), 870–880.
-
(2013)
Immunity
, vol.38
, Issue.5
, pp. 870-880
-
-
Paludan, S.R.1
Bowie, A.G.2
-
44
-
-
84878173821
-
Cytosolic sensing of viruses
-
Goubau, D., Deddouche, S., Reis e Sousa, C., Cytosolic sensing of viruses. Immunity 38:5 (2013), 855–869.
-
(2013)
Immunity
, vol.38
, Issue.5
, pp. 855-869
-
-
Goubau, D.1
Deddouche, S.2
Reis e Sousa, C.3
-
45
-
-
84877004303
-
RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells
-
Hagmann, C.A., Herzner, A.M., Abdullah, Z., Zillinger, T., Jakobs, C., Schuberth, C., Coch, C., Higgins, P.G., Wisplinghoff, H., Barchet, W., Hornung, V., Hartmann, G., Schlee, M., RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells. PLoS ONE, 8(4), 2013, e62872.
-
(2013)
PLoS ONE
, vol.8
, Issue.4
, pp. e62872
-
-
Hagmann, C.A.1
Herzner, A.M.2
Abdullah, Z.3
Zillinger, T.4
Jakobs, C.5
Schuberth, C.6
Coch, C.7
Higgins, P.G.8
Wisplinghoff, H.9
Barchet, W.10
Hornung, V.11
Hartmann, G.12
Schlee, M.13
-
46
-
-
77955294800
-
Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol
-
Sauer, J.D., Witte, C.E., Zemansky, J., Hanson, B., Lauer, P., Portnoy, D.A., Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol. Cell Host Microbe 7:5 (2010), 412–419.
-
(2010)
Cell Host Microbe
, vol.7
, Issue.5
, pp. 412-419
-
-
Sauer, J.D.1
Witte, C.E.2
Zemansky, J.3
Hanson, B.4
Lauer, P.5
Portnoy, D.A.6
-
47
-
-
84868569570
-
RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids
-
Abdullah, Z., Schlee, M., Roth, S., Mraheil, M.A., Barchet, W., Bottcher, J., Hain, T., Geiger, S., Hayakawa, Y., Fritz, J.H., Civril, F., Hopfner, K.P., Kurts, C., Ruland, J., Hartmann, G., Chakraborty, T., Knolle, P.A., RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO J. 31:21 (2012), 4153–4164.
-
(2012)
EMBO J.
, vol.31
, Issue.21
, pp. 4153-4164
-
-
Abdullah, Z.1
Schlee, M.2
Roth, S.3
Mraheil, M.A.4
Barchet, W.5
Bottcher, J.6
Hain, T.7
Geiger, S.8
Hayakawa, Y.9
Fritz, J.H.10
Civril, F.11
Hopfner, K.P.12
Kurts, C.13
Ruland, J.14
Hartmann, G.15
Chakraborty, T.16
Knolle, P.A.17
-
48
-
-
84861170022
-
Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages
-
Manzanillo, P.S., Shiloh, M.U., Portnoy, D.A., Cox, J.S., Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages. Cell Host Microbe 11:5 (2012), 469–480.
-
(2012)
Cell Host Microbe
, vol.11
, Issue.5
, pp. 469-480
-
-
Manzanillo, P.S.1
Shiloh, M.U.2
Portnoy, D.A.3
Cox, J.S.4
-
49
-
-
0004250845
-
Fields Virology
-
sixth ed. Wolters Kluwer/Lippincott Williams & Wilkins Health Philadelphia
-
Fields, B.N., Knipe, D.M., Howley, P.M., Fields Virology. sixth ed., 2013, Wolters Kluwer/Lippincott Williams & Wilkins Health, Philadelphia.
-
(2013)
-
-
Fields, B.N.1
Knipe, D.M.2
Howley, P.M.3
-
50
-
-
84874246480
-
Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors
-
Horan, K.A., Hansen, K., Jakobsen, M.R., Holm, C.K., Soby, S., Unterholzner, L., Thompson, M., West, J.A., Iversen, M.B., Rasmussen, S.B., Ellermann-Eriksen, S., Kurt-Jones, E., Landolfo, S., Damania, B., Melchjorsen, J., Bowie, A.G., Fitzgerald, K.A., Paludan, S.R., Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors. J. Immunol. 190:5 (2013), 2311–2319.
-
(2013)
J. Immunol.
, vol.190
, Issue.5
, pp. 2311-2319
-
-
Horan, K.A.1
Hansen, K.2
Jakobsen, M.R.3
Holm, C.K.4
Soby, S.5
Unterholzner, L.6
Thompson, M.7
West, J.A.8
Iversen, M.B.9
Rasmussen, S.B.10
Ellermann-Eriksen, S.11
Kurt-Jones, E.12
Landolfo, S.13
Damania, B.14
Melchjorsen, J.15
Bowie, A.G.16
Fitzgerald, K.A.17
Paludan, S.R.18
-
51
-
-
33646453915
-
Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses
-
Weber, F., Wagner, V., Rasmussen, S.B., Hartmann, R., Paludan, S.R., Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. J. Virol. 80:10 (2006), 5059–5064.
-
(2006)
J. Virol.
, vol.80
, Issue.10
, pp. 5059-5064
-
-
Weber, F.1
Wagner, V.2
Rasmussen, S.B.3
Hartmann, R.4
Paludan, S.R.5
-
52
-
-
84928537166
-
Mitochondrial DNA stress primes the antiviral innate immune response
-
West, A.P., Khoury-Hanold, W., Staron, M., Tal, M.C., Pineda, C.M., Lang, S.M., Bestwick, M., Duguay, B.A., Raimundo, N., MacDuff, D.A., Kaech, S.M., Smiley, J.R., Means, R.E., Iwasaki, A., Shadel, G.S., Mitochondrial DNA stress primes the antiviral innate immune response. Nature 520:7548 (2015), 553–557.
-
(2015)
Nature
, vol.520
, Issue.7548
, pp. 553-557
-
-
West, A.P.1
Khoury-Hanold, W.2
Staron, M.3
Tal, M.C.4
Pineda, C.M.5
Lang, S.M.6
Bestwick, M.7
Duguay, B.A.8
Raimundo, N.9
MacDuff, D.A.10
Kaech, S.M.11
Smiley, J.R.12
Means, R.E.13
Iwasaki, A.14
Shadel, G.S.15
-
53
-
-
84984848329
-
The mechanism for type i interferon induction by mycobacterium tuberculosis is bacterial strain-dependent
-
Wiens, K.E., Ernst, J.D., The mechanism for type i interferon induction by mycobacterium tuberculosis is bacterial strain-dependent. PLoS Pathog., 12(8), 2016, e1005809.
-
(2016)
PLoS Pathog.
, vol.12
, Issue.8
, pp. e1005809
-
-
Wiens, K.E.1
Ernst, J.D.2
-
54
-
-
0037154176
-
Mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
-
Kang, D.C., Gopalkrishnan, R.V., Wu, Q., Jankowsky, E., Pyle, A.M., Fisher, P.B., Mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proc. Natl. Acad. Sci. USA 99:2 (2002), 637–642.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, Issue.2
, pp. 637-642
-
-
Kang, D.C.1
Gopalkrishnan, R.V.2
Wu, Q.3
Jankowsky, E.4
Pyle, A.M.5
Fisher, P.B.6
-
55
-
-
33750984771
-
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates
-
Pichlmair, A., Schulz, O., Tan, C.P., Naslund, T.I., Liljestrom, P., Weber, F., Reis e Sousa, C., RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 314:5801 (2006), 997–1001.
-
(2006)
Science
, vol.314
, Issue.5801
, pp. 997-1001
-
-
Pichlmair, A.1
Schulz, O.2
Tan, C.P.3
Naslund, T.I.4
Liljestrom, P.5
Weber, F.6
Reis e Sousa, C.7
-
56
-
-
33646561864
-
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells
-
Marques, J.T., Devosse, T., Wang, D., Zamanian-Daryoush, M., Serbinowski, P., Hartmann, R., Fujita, T., Behlke, M.A., Williams, B.R., A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nat. Biotechnol. 24:5 (2006), 559–565.
-
(2006)
Nat. Biotechnol.
, vol.24
, Issue.5
, pp. 559-565
-
-
Marques, J.T.1
Devosse, T.2
Wang, D.3
Zamanian-Daryoush, M.4
Serbinowski, P.5
Hartmann, R.6
Fujita, T.7
Behlke, M.A.8
Williams, B.R.9
-
57
-
-
46949097299
-
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
-
Kato, H., Takeuchi, O., Mikamo-Satoh, E., Hirai, R., Kawai, T., Matsushita, K., Hiiragi, A., Dermody, T.S., Fujita, T., Akira, S., Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J. Exp. Med. 205:7 (2008), 1601–1610.
-
(2008)
J. Exp. Med.
, vol.205
, Issue.7
, pp. 1601-1610
-
-
Kato, H.1
Takeuchi, O.2
Mikamo-Satoh, E.3
Hirai, R.4
Kawai, T.5
Matsushita, K.6
Hiiragi, A.7
Dermody, T.S.8
Fujita, T.9
Akira, S.10
-
58
-
-
67749133995
-
5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
-
Schmidt, A., Schwerd, T., Hamm, W., Hellmuth, J.C., Cui, S., Wenzel, M., Hoffmann, F.S., Michallet, M.C., Besch, R., Hopfner, K.P., Endres, S., Rothenfusser, S., 5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I. Proc. Natl. Acad. Sci. USA 106:29 (2009), 12067–12072.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, Issue.29
, pp. 12067-12072
-
-
Schmidt, A.1
Schwerd, T.2
Hamm, W.3
Hellmuth, J.C.4
Cui, S.5
Wenzel, M.6
Hoffmann, F.S.7
Michallet, M.C.8
Besch, R.9
Hopfner, K.P.10
Endres, S.11
Rothenfusser, S.12
-
59
-
-
84966355917
-
The auto inhibitory CARD2-Hel2i interface of RIG-I governs RNA selection
-
Ramanathan, A., Devarkar, S.C., Jiang, F., Miller, M.T., Khan, A.G., Marcotrigiano, J., Patel, S.S., The auto inhibitory CARD2-Hel2i interface of RIG-I governs RNA selection. Nucleic Acids Res. 44:2 (2016), 896–909.
-
(2016)
Nucleic Acids Res.
, vol.44
, Issue.2
, pp. 896-909
-
-
Ramanathan, A.1
Devarkar, S.C.2
Jiang, F.3
Miller, M.T.4
Khan, A.G.5
Marcotrigiano, J.6
Patel, S.S.7
-
60
-
-
84937706124
-
A conserved histidine in the RNA sensor RIG-I controls immune tolerance to N1–2′O-methylated self RNA
-
Schuberth-Wagner, C., Ludwig, J., Bruder, A.K., Herzner, A.M., Zillinger, T., Goldeck, M., Schmidt, T., Schmid-Burgk, J.L., Kerber, R., Wolter, S., Stumpel, J.P., Roth, A., Bartok, E., Drosten, C., Coch, C., Hornung, V., Barchet, W., Kummerer, B.M., Hartmann, G., Schlee, M., A conserved histidine in the RNA sensor RIG-I controls immune tolerance to N1–2′O-methylated self RNA. Immunity 43:1 (2015), 41–51.
-
(2015)
Immunity
, vol.43
, Issue.1
, pp. 41-51
-
-
Schuberth-Wagner, C.1
Ludwig, J.2
Bruder, A.K.3
Herzner, A.M.4
Zillinger, T.5
Goldeck, M.6
Schmidt, T.7
Schmid-Burgk, J.L.8
Kerber, R.9
Wolter, S.10
Stumpel, J.P.11
Roth, A.12
Bartok, E.13
Drosten, C.14
Coch, C.15
Hornung, V.16
Barchet, W.17
Kummerer, B.M.18
Hartmann, G.19
Schlee, M.20
more..
-
61
-
-
33750976374
-
5′-Triphosphate RNA is the ligand for RIG-I
-
Hornung, V., Ellegast, J., Kim, S., Brzozka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.K., Schlee, M., Endres, S., Hartmann, G., 5′-Triphosphate RNA is the ligand for RIG-I. Science 314:5801 (2006), 994–997.
-
(2006)
Science
, vol.314
, Issue.5801
, pp. 994-997
-
-
Hornung, V.1
Ellegast, J.2
Kim, S.3
Brzozka, K.4
Jung, A.5
Kato, H.6
Poeck, H.7
Akira, S.8
Conzelmann, K.K.9
Schlee, M.10
Endres, S.11
Hartmann, G.12
-
62
-
-
47949092573
-
Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA
-
Saito, T., Owen, D.M., Jiang, F., Marcotrigiano, J., Gale, M. Jr., Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA. Nature 454:7203 (2008), 523–527.
-
(2008)
Nature
, vol.454
, Issue.7203
, pp. 523-527
-
-
Saito, T.1
Owen, D.M.2
Jiang, F.3
Marcotrigiano, J.4
Gale, M.5
-
63
-
-
39649092731
-
Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses
-
Takahasi, K., Yoneyama, M., Nishihori, T., Hirai, R., Kumeta, H., Narita, R., Gale, M. Jr., Inagaki, F., Fujita, T., Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. Mol. Cell 29:4 (2008), 428–440.
-
(2008)
Mol. Cell
, vol.29
, Issue.4
, pp. 428-440
-
-
Takahasi, K.1
Yoneyama, M.2
Nishihori, T.3
Hirai, R.4
Kumeta, H.5
Narita, R.6
Gale, M.7
Inagaki, F.8
Fujita, T.9
-
64
-
-
38649089789
-
The C-terminal regulatory domain is the RNA 5′-triphosphate sensor of RIG-I
-
Cui, S., Eisenacher, K., Kirchhofer, A., Brzozka, K., Lammens, A., Lammens, K., Fujita, T., Conzelmann, K.K., Krug, A., Hopfner, K.P., The C-terminal regulatory domain is the RNA 5′-triphosphate sensor of RIG-I. Mol. Cell 29:2 (2008), 169–179.
-
(2008)
Mol. Cell
, vol.29
, Issue.2
, pp. 169-179
-
-
Cui, S.1
Eisenacher, K.2
Kirchhofer, A.3
Brzozka, K.4
Lammens, A.5
Lammens, K.6
Fujita, T.7
Conzelmann, K.K.8
Krug, A.9
Hopfner, K.P.10
-
65
-
-
68049089651
-
Recognition of 5′ triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus
-
Schlee, M., Roth, A., Hornung, V., Hagmann, C.A., Wimmenauer, V., Barchet, W., Coch, C., Janke, M., Mihailovic, A., Wardle, G., Juranek, S., Kato, H., Kawai, T., Poeck, H., Fitzgerald, K.A., Takeuchi, O., Akira, S., Tuschl, T., Latz, E., Ludwig, J., Hartmann, G., Recognition of 5′ triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity 31:1 (2009), 25–34.
-
(2009)
Immunity
, vol.31
, Issue.1
, pp. 25-34
-
-
Schlee, M.1
Roth, A.2
Hornung, V.3
Hagmann, C.A.4
Wimmenauer, V.5
Barchet, W.6
Coch, C.7
Janke, M.8
Mihailovic, A.9
Wardle, G.10
Juranek, S.11
Kato, H.12
Kawai, T.13
Poeck, H.14
Fitzgerald, K.A.15
Takeuchi, O.16
Akira, S.17
Tuschl, T.18
Latz, E.19
Ludwig, J.20
Hartmann, G.21
more..
-
66
-
-
77957997708
-
Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing
-
Baum, A., Sachidanandam, R., Garcia-Sastre, A., Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing. Proc. Natl. Acad. Sci. USA 107:37 (2010), 16303–16308.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, Issue.37
, pp. 16303-16308
-
-
Baum, A.1
Sachidanandam, R.2
Garcia-Sastre, A.3
-
67
-
-
80054703126
-
Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA
-
Kowalinski, E., Lunardi, T., McCarthy, A.A., Louber, J., Brunel, J., Grigorov, B., Gerlier, D., Cusack, S., Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA. Cell 147:2 (2011), 423–435.
-
(2011)
Cell
, vol.147
, Issue.2
, pp. 423-435
-
-
Kowalinski, E.1
Lunardi, T.2
McCarthy, A.A.3
Louber, J.4
Brunel, J.5
Grigorov, B.6
Gerlier, D.7
Cusack, S.8
-
68
-
-
80054685883
-
Structural insights into RNA recognition by RIG-I
-
Luo, D., Ding, S.C., Vela, A., Kohlway, A., Lindenbach, B.D., Pyle, A.M., Structural insights into RNA recognition by RIG-I. Cell 147:2 (2011), 409–422.
-
(2011)
Cell
, vol.147
, Issue.2
, pp. 409-422
-
-
Luo, D.1
Ding, S.C.2
Vela, A.3
Kohlway, A.4
Lindenbach, B.D.5
Pyle, A.M.6
-
69
-
-
81555204380
-
Structural basis of RNA recognition and activation by innate immune receptor RIG-I
-
Jiang, F., Ramanathan, A., Miller, M.T., Tang, G.Q., Gale, M. Jr., Patel, S.S., Marcotrigiano, J., Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature 479:7373 (2011), 423–427.
-
(2011)
Nature
, vol.479
, Issue.7373
, pp. 423-427
-
-
Jiang, F.1
Ramanathan, A.2
Miller, M.T.3
Tang, G.Q.4
Gale, M.5
Patel, S.S.6
Marcotrigiano, J.7
-
70
-
-
79952325540
-
Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5′ triphosphate
-
Lu, C., Ranjith-Kumar, C.T., Hao, L., Kao, C.C., Li, P., Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5′ triphosphate. Nucleic Acids Res. 39:4 (2011), 1565–1575.
-
(2011)
Nucleic Acids Res.
, vol.39
, Issue.4
, pp. 1565-1575
-
-
Lu, C.1
Ranjith-Kumar, C.T.2
Hao, L.3
Kao, C.C.4
Li, P.5
-
71
-
-
77955481642
-
The structural basis of 5′ triphosphate double-stranded RNA recognition by RIG-I C-terminal domain
-
Lu, C., Xu, H., Ranjith-Kumar, C.T., Brooks, M.T., Hou, T.Y., Hu, F., Herr, A.B., Strong, R.K., Kao, C.C., Li, P., The structural basis of 5′ triphosphate double-stranded RNA recognition by RIG-I C-terminal domain. Structure 18:8 (2010), 1032–1043.
-
(2010)
Structure
, vol.18
, Issue.8
, pp. 1032-1043
-
-
Lu, C.1
Xu, H.2
Ranjith-Kumar, C.T.3
Brooks, M.T.4
Hou, T.Y.5
Hu, F.6
Herr, A.B.7
Strong, R.K.8
Kao, C.C.9
Li, P.10
-
72
-
-
77954386541
-
Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I
-
Wang, Y., Ludwig, J., Schuberth, C., Goldeck, M., Schlee, M., Li, H., Juranek, S., Sheng, G., Micura, R., Tuschl, T., Hartmann, G., Patel, D.J., Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nat. Struct. Mol. Biol. 17:7 (2010), 781–787.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, Issue.7
, pp. 781-787
-
-
Wang, Y.1
Ludwig, J.2
Schuberth, C.3
Goldeck, M.4
Schlee, M.5
Li, H.6
Juranek, S.7
Sheng, G.8
Micura, R.9
Tuschl, T.10
Hartmann, G.11
Patel, D.J.12
-
73
-
-
33846307026
-
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
-
Saito, T., Hirai, R., Loo, Y.M., Owen, D., Johnson, C.L., Sinha, S.C., Akira, S., Fujita, T., Gale, M. Jr., Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc. Natl. Acad. Sci. USA 104:2 (2007), 582–587.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, Issue.2
, pp. 582-587
-
-
Saito, T.1
Hirai, R.2
Loo, Y.M.3
Owen, D.4
Johnson, C.L.5
Sinha, S.C.6
Akira, S.7
Fujita, T.8
Gale, M.9
-
74
-
-
84908192059
-
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
-
Goubau, D., Schlee, M., Deddouche, S., Pruijssers, A.J., Zillinger, T., Goldeck, M., Schuberth, C., Van der Veen, A.G., Fujimura, T., Rehwinkel, J., Iskarpatyoti, J.A., Barchet, W., Ludwig, J., Dermody, T.S., Hartmann, G., Reis e Sousa, C., Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates. Nature 514:7522 (2014), 372–375.
-
(2014)
Nature
, vol.514
, Issue.7522
, pp. 372-375
-
-
Goubau, D.1
Schlee, M.2
Deddouche, S.3
Pruijssers, A.J.4
Zillinger, T.5
Goldeck, M.6
Schuberth, C.7
Van der Veen, A.G.8
Fujimura, T.9
Rehwinkel, J.10
Iskarpatyoti, J.A.11
Barchet, W.12
Ludwig, J.13
Dermody, T.S.14
Hartmann, G.15
Reis e Sousa, C.16
-
75
-
-
84872604349
-
Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5
-
Wu, B., Peisley, A., Richards, C., Yao, H., Zeng, X., Lin, C., Chu, F., Walz, T., Hur, S., Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5. Cell 152:1–2 (2013), 276–289.
-
(2013)
Cell
, vol.152
, Issue.1-2
, pp. 276-289
-
-
Wu, B.1
Peisley, A.2
Richards, C.3
Yao, H.4
Zeng, X.5
Lin, C.6
Chu, F.7
Walz, T.8
Hur, S.9
-
76
-
-
70349728538
-
Activation of MDA5 requires higher-order RNA structures generated during virus infection
-
Pichlmair, A., Schulz, O., Tan, C.P., Rehwinkel, J., Kato, H., Takeuchi, O., Akira, S., Way, M., Schiavo, G., Reis e Sousa, C., Activation of MDA5 requires higher-order RNA structures generated during virus infection. J. Virol. 83:20 (2009), 10761–10769.
-
(2009)
J. Virol.
, vol.83
, Issue.20
, pp. 10761-10769
-
-
Pichlmair, A.1
Schulz, O.2
Tan, C.P.3
Rehwinkel, J.4
Kato, H.5
Takeuchi, O.6
Akira, S.7
Way, M.8
Schiavo, G.9
Reis e Sousa, C.10
-
77
-
-
67651232539
-
Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5
-
Li, X., Lu, C., Stewart, M., Xu, H., Strong, R.K., Igumenova, T., Li, P., Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5. Arch. Biochem. Biophys. 488:1 (2009), 23–33.
-
(2009)
Arch. Biochem. Biophys.
, vol.488
, Issue.1
, pp. 23-33
-
-
Li, X.1
Lu, C.2
Stewart, M.3
Xu, H.4
Strong, R.K.5
Igumenova, T.6
Li, P.7
-
78
-
-
67650510680
-
Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors
-
Takahasi, K., Kumeta, H., Tsuduki, N., Narita, R., Shigemoto, T., Hirai, R., Yoneyama, M., Horiuchi, M., Ogura, K., Fujita, T., Inagaki, F., Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors. J. Biol. Chem. 284:26 (2009), 17465–17474.
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.26
, pp. 17465-17474
-
-
Takahasi, K.1
Kumeta, H.2
Tsuduki, N.3
Narita, R.4
Shigemoto, T.5
Hirai, R.6
Yoneyama, M.7
Horiuchi, M.8
Ogura, K.9
Fujita, T.10
Inagaki, F.11
-
79
-
-
84859427527
-
MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA
-
Berke, I.C., Modis, Y., MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA. EMBO J. 31:7 (2012), 1714–1726.
-
(2012)
EMBO J.
, vol.31
, Issue.7
, pp. 1714-1726
-
-
Berke, I.C.1
Modis, Y.2
-
80
-
-
84862909216
-
Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition
-
Peisley, A., Lin, C., Wu, B., Orme-Johnson, M., Liu, M., Walz, T., Hur, S., Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition. Proc. Natl. Acad. Sci. USA 108:52 (2011), 21010–21015.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, Issue.52
, pp. 21010-21015
-
-
Peisley, A.1
Lin, C.2
Wu, B.3
Orme-Johnson, M.4
Liu, M.5
Walz, T.6
Hur, S.7
-
81
-
-
84868538362
-
MDA5 assembles into a polar helical filament on dsRNA
-
Berke, I.C., Yu, X., Modis, Y., Egelman, E.H., MDA5 assembles into a polar helical filament on dsRNA. Proc. Natl. Acad. Sci. USA 109:45 (2012), 18437–18441.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, Issue.45
, pp. 18437-18441
-
-
Berke, I.C.1
Yu, X.2
Modis, Y.3
Egelman, E.H.4
-
82
-
-
84901376043
-
In vivo ligands of MDA5 and RIG-I in measles virus-infected cells
-
Runge, S., Sparrer, K.M., Lassig, C., Hembach, K., Baum, A., Garcia-Sastre, A., Soding, J., Conzelmann, K.K., Hopfner, K.P., In vivo ligands of MDA5 and RIG-I in measles virus-infected cells. PLoS Pathog., 10(4), 2014, e1004081.
-
(2014)
PLoS Pathog.
, vol.10
, Issue.4
, pp. e1004081
-
-
Runge, S.1
Sparrer, K.M.2
Lassig, C.3
Hembach, K.4
Baum, A.5
Garcia-Sastre, A.6
Soding, J.7
Conzelmann, K.K.8
Hopfner, K.P.9
-
83
-
-
37349052379
-
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity
-
Loo, Y.M., Fornek, J., Crochet, N., Bajwa, G., Perwitasari, O., Martinez-Sobrido, L., Akira, S., Gill, M.A., Garcia-Sastre, A., Katze, M.G., Gale, M. Jr., Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J. Virol. 82:1 (2008), 335–345.
-
(2008)
J. Virol.
, vol.82
, Issue.1
, pp. 335-345
-
-
Loo, Y.M.1
Fornek, J.2
Crochet, N.3
Bajwa, G.4
Perwitasari, O.5
Martinez-Sobrido, L.6
Akira, S.7
Gill, M.A.8
Garcia-Sastre, A.9
Katze, M.G.10
Gale, M.11
-
84
-
-
84870476784
-
MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells
-
Feng, Q., Hato, S.V., Langereis, M.A., Zoll, J., Virgen-Slane, R., Peisley, A., Hur, S., Semler, B.L., van Rij, R.P., van Kuppeveld, F.J., MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells. Cell Rep. 2:5 (2012), 1187–1196.
-
(2012)
Cell Rep.
, vol.2
, Issue.5
, pp. 1187-1196
-
-
Feng, Q.1
Hato, S.V.2
Langereis, M.A.3
Zoll, J.4
Virgen-Slane, R.5
Peisley, A.6
Hur, S.7
Semler, B.L.8
van Rij, R.P.9
van Kuppeveld, F.J.10
-
85
-
-
84886878320
-
The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
-
Errett, J.S., Suthar, M.S., McMillan, A., Diamond, M.S., Gale, M. Jr., The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection. J. Virol. 87:21 (2013), 11416–11425.
-
(2013)
J. Virol.
, vol.87
, Issue.21
, pp. 11416-11425
-
-
Errett, J.S.1
Suthar, M.S.2
McMillan, A.3
Diamond, M.S.4
Gale, M.5
-
86
-
-
84884157315
-
Master sensors of pathogenic RNA – RIG-I like receptors
-
Schlee, M., Master sensors of pathogenic RNA – RIG-I like receptors. Immunobiology 218:11 (2013), 1322–1335.
-
(2013)
Immunobiology
, vol.218
, Issue.11
, pp. 1322-1335
-
-
Schlee, M.1
-
87
-
-
84875167118
-
Incoming RNA virus nucleocapsids containing a 5′-triphosphorylated genome activate RIG-I and antiviral signaling
-
Weber, M., Gawanbacht, A., Habjan, M., Rang, A., Borner, C., Schmidt, A.M., Veitinger, S., Jacob, R., Devignot, S., Kochs, G., Garcia-Sastre, A., Weber, F., Incoming RNA virus nucleocapsids containing a 5′-triphosphorylated genome activate RIG-I and antiviral signaling. Cell Host Microbe 13:3 (2013), 336–346.
-
(2013)
Cell Host Microbe
, vol.13
, Issue.3
, pp. 336-346
-
-
Weber, M.1
Gawanbacht, A.2
Habjan, M.3
Rang, A.4
Borner, C.5
Schmidt, A.M.6
Veitinger, S.7
Jacob, R.8
Devignot, S.9
Kochs, G.10
Garcia-Sastre, A.11
Weber, F.12
-
88
-
-
84926139701
-
Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I
-
Weber, M., Sediri, H., Felgenhauer, U., Binzen, I., Banfer, S., Jacob, R., Brunotte, L., Garcia-Sastre, A., Schmid-Burgk, J.L., Schmidt, T., Hornung, V., Kochs, G., Schwemmle, M., Klenk, H.D., Weber, F., Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I. Cell Host Microbe 17:3 (2015), 309–319.
-
(2015)
Cell Host Microbe
, vol.17
, Issue.3
, pp. 309-319
-
-
Weber, M.1
Sediri, H.2
Felgenhauer, U.3
Binzen, I.4
Banfer, S.5
Jacob, R.6
Brunotte, L.7
Garcia-Sastre, A.8
Schmid-Burgk, J.L.9
Schmidt, T.10
Hornung, V.11
Kochs, G.12
Schwemmle, M.13
Klenk, H.D.14
Weber, F.15
-
89
-
-
75749140581
-
RIG-I detects viral genomic RNA during negative-strand RNA virus infection
-
Rehwinkel, J., Tan, C.P., Goubau, D., Schulz, O., Pichlmair, A., Bier, K., Robb, N., Vreede, F., Barclay, W., Fodor, E., Reis e Sousa, C., RIG-I detects viral genomic RNA during negative-strand RNA virus infection. Cell 140:3 (2010), 397–408.
-
(2010)
Cell
, vol.140
, Issue.3
, pp. 397-408
-
-
Rehwinkel, J.1
Tan, C.P.2
Goubau, D.3
Schulz, O.4
Pichlmair, A.5
Bier, K.6
Robb, N.7
Vreede, F.8
Barclay, W.9
Fodor, E.10
Reis e Sousa, C.11
-
90
-
-
84991247078
-
Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5′-triphosphate
-
Lee, M.K., Kim, H.E., Park, E.B., Lee, J., Kim, K.H., Lim, K., Yum, S., Lee, Y.H., Kang, S.J., Lee, J.H., Choi, B.S., Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5′-triphosphate. Nucleic Acids Res., 2016.
-
(2016)
Nucleic Acids Res.
-
-
Lee, M.K.1
Kim, H.E.2
Park, E.B.3
Lee, J.4
Kim, K.H.5
Lim, K.6
Yum, S.7
Lee, Y.H.8
Kang, S.J.9
Lee, J.H.10
Choi, B.S.11
-
91
-
-
84937639038
-
In vivo RNAi screening identifies MDA5 as a significant contributor to the cellular defense against influenza A virus
-
Benitez, A.A., Panis, M., Xue, J., Varble, A., Shim, J.V., Frick, A.L., Lopez, C.B., Sachs, D., tenOever, B.R., In vivo RNAi screening identifies MDA5 as a significant contributor to the cellular defense against influenza A virus. Cell Rep. 11:11 (2015), 1714–1726.
-
(2015)
Cell Rep.
, vol.11
, Issue.11
, pp. 1714-1726
-
-
Benitez, A.A.1
Panis, M.2
Xue, J.3
Varble, A.4
Shim, J.V.5
Frick, A.L.6
Lopez, C.B.7
Sachs, D.8
tenOever, B.R.9
-
92
-
-
72849147109
-
Both RIG-I and MDA5 RNA helicases contribute to the induction of alpha/beta interferon in measles virus-infected human cells
-
Ikegame, S., Takeda, M., Ohno, S., Nakatsu, Y., Nakanishi, Y., Yanagi, Y., Both RIG-I and MDA5 RNA helicases contribute to the induction of alpha/beta interferon in measles virus-infected human cells. J. Virol. 84:1 (2010), 372–379.
-
(2010)
J. Virol.
, vol.84
, Issue.1
, pp. 372-379
-
-
Ikegame, S.1
Takeda, M.2
Ohno, S.3
Nakatsu, Y.4
Nakanishi, Y.5
Yanagi, Y.6
-
93
-
-
22544455673
-
Cell type-specific involvement of RIG-I in antiviral response
-
Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T., Takeda, K., Fujita, T., Takeuchi, O., Akira, S., Cell type-specific involvement of RIG-I in antiviral response. Immunity 23:1 (2005), 19–28.
-
(2005)
Immunity
, vol.23
, Issue.1
, pp. 19-28
-
-
Kato, H.1
Sato, S.2
Yoneyama, M.3
Yamamoto, M.4
Uematsu, S.5
Matsui, K.6
Tsujimura, T.7
Takeda, K.8
Fujita, T.9
Takeuchi, O.10
Akira, S.11
-
94
-
-
84964247470
-
Comparative analysis of viral RNA signatures on different RIG-I-like receptors
-
Sanchez David, R.Y., Combredet, C., Sismeiro, O., Dillies, M.A., Jagla, B., Coppee, J.Y., Mura, M., Guerbois Galla, M., Despres, P., Tangy, F., Komarova, A.V., Comparative analysis of viral RNA signatures on different RIG-I-like receptors. eLife, 5, 2016.
-
(2016)
eLife
, vol.5
-
-
Sanchez David, R.Y.1
Combredet, C.2
Sismeiro, O.3
Dillies, M.A.4
Jagla, B.5
Coppee, J.Y.6
Mura, M.7
Guerbois Galla, M.8
Despres, P.9
Tangy, F.10
Komarova, A.V.11
-
95
-
-
84959464455
-
Leader-containing uncapped viral transcript activates RIG-I in antiviral stress granules
-
Oh, S.W., Onomoto, K., Wakimoto, M., Onoguchi, K., Ishidate, F., Fujiwara, T., Yoneyama, M., Kato, H., Fujita, T., Leader-containing uncapped viral transcript activates RIG-I in antiviral stress granules. PLoS Pathog., 12(2), 2016, e1005444.
-
(2016)
PLoS Pathog.
, vol.12
, Issue.2
, pp. e1005444
-
-
Oh, S.W.1
Onomoto, K.2
Wakimoto, M.3
Onoguchi, K.4
Ishidate, F.5
Fujiwara, T.6
Yoneyama, M.7
Kato, H.8
Fujita, T.9
-
96
-
-
34547157869
-
Cytosolic 5′-triphosphate ended viral leader transcript of measles virus as activator of the RIG I-mediated interferon response
-
Plumet, S., Herschke, F., Bourhis, J.-M., Valentin, H., Longhi, S., Gerlier, D., Cytosolic 5′-triphosphate ended viral leader transcript of measles virus as activator of the RIG I-mediated interferon response. PLoS ONE, 2(3), 2007, e279.
-
(2007)
PLoS ONE
, vol.2
, Issue.3
, pp. e279
-
-
Plumet, S.1
Herschke, F.2
Bourhis, J.-M.3
Valentin, H.4
Longhi, S.5
Gerlier, D.6
-
97
-
-
0024589265
-
Distribution of 5′-triphosphate termini on the mRNA of Escherichia coli
-
Bieger, C.D., Nierlich, D.P., Distribution of 5′-triphosphate termini on the mRNA of Escherichia coli. J. Bacteriol. 171:1 (1989), 141–147.
-
(1989)
J. Bacteriol.
, vol.171
, Issue.1
, pp. 141-147
-
-
Bieger, C.D.1
Nierlich, D.P.2
-
98
-
-
66149110970
-
Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori
-
Rad, R., Ballhorn, W., Voland, P., Eisenacher, K., Mages, J., Rad, L., Ferstl, R., Lang, R., Wagner, H., Schmid, R.M., Bauer, S., Prinz, C., Kirschning, C.J., Krug, A., Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori. Gastroenterology 136:7 (2009), 2247–2257.
-
(2009)
Gastroenterology
, vol.136
, Issue.7
, pp. 2247-2257
-
-
Rad, R.1
Ballhorn, W.2
Voland, P.3
Eisenacher, K.4
Mages, J.5
Rad, L.6
Ferstl, R.7
Lang, R.8
Wagner, H.9
Schmid, R.M.10
Bauer, S.11
Prinz, C.12
Kirschning, C.J.13
Krug, A.14
-
99
-
-
73549090166
-
Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila
-
Monroe, K.M., McWhirter, S.M., Vance, R.E., Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila. PLoS Pathog., 5(11), 2009, e1000665.
-
(2009)
PLoS Pathog.
, vol.5
, Issue.11
, pp. e1000665
-
-
Monroe, K.M.1
McWhirter, S.M.2
Vance, R.E.3
-
100
-
-
84891874162
-
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection
-
Liehl, P., Zuzarte-Luis, V., Chan, J., Zillinger, T., Baptista, F., Carapau, D., Konert, M., Hanson, K.K., Carret, C., Lassnig, C., Muller, M., Kalinke, U., Saeed, M., Chora, A.F., Golenbock, D.T., Strobl, B., Prudencio, M., Coelho, L.P., Kappe, S.H., Superti-Furga, G., Pichlmair, A., Vigario, A.M., Rice, C.M., Fitzgerald, K.A., Barchet, W., Mota, M.M., Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat. Med. 20:1 (2014), 47–53.
-
(2014)
Nat. Med.
, vol.20
, Issue.1
, pp. 47-53
-
-
Liehl, P.1
Zuzarte-Luis, V.2
Chan, J.3
Zillinger, T.4
Baptista, F.5
Carapau, D.6
Konert, M.7
Hanson, K.K.8
Carret, C.9
Lassnig, C.10
Muller, M.11
Kalinke, U.12
Saeed, M.13
Chora, A.F.14
Golenbock, D.T.15
Strobl, B.16
Prudencio, M.17
Coelho, L.P.18
Kappe, S.H.19
Superti-Furga, G.20
Pichlmair, A.21
Vigario, A.M.22
Rice, C.M.23
Fitzgerald, K.A.24
Barchet, W.25
Mota, M.M.26
more..
-
101
-
-
34547960175
-
Small self-RNA generated by RNase L amplifies antiviral innate immunity
-
Malathi, K., Dong, B., Gale, M. Jr., Silverman, R.H., Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature 448:7155 (2007), 816–819.
-
(2007)
Nature
, vol.448
, Issue.7155
, pp. 816-819
-
-
Malathi, K.1
Dong, B.2
Gale, M.3
Silverman, R.H.4
-
102
-
-
78149324490
-
RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP
-
Malathi, K., Saito, T., Crochet, N., Barton, D.J., Gale, M. Jr., Silverman, R.H., RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP. RNA 16:11 (2010), 2108–2119.
-
(2010)
RNA
, vol.16
, Issue.11
, pp. 2108-2119
-
-
Malathi, K.1
Saito, T.2
Crochet, N.3
Barton, D.J.4
Gale, M.5
Silverman, R.H.6
-
103
-
-
79952125382
-
Activation of IFN-β expression by a viral mRNA through RNase L and MDA5
-
Luthra, P., Sun, D., Silverman, R.H., He, B., Activation of IFN-β expression by a viral mRNA through RNase L and MDA5. Proc. Natl. Acad. Sci. USA 108:5 (2011), 2118–2123.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, Issue.5
, pp. 2118-2123
-
-
Luthra, P.1
Sun, D.2
Silverman, R.H.3
He, B.4
-
104
-
-
77953308262
-
Unpaired 5′ ppp-nucleotides, as found in arenavirus double-stranded RNA panhandles, are not recognized by RIG-I
-
Marq, J.B., Kolakofsky, D., Garcin, D., Unpaired 5′ ppp-nucleotides, as found in arenavirus double-stranded RNA panhandles, are not recognized by RIG-I. J. Biol. Chem. 285:24 (2010), 18208–18216.
-
(2010)
J. Biol. Chem.
, vol.285
, Issue.24
, pp. 18208-18216
-
-
Marq, J.B.1
Kolakofsky, D.2
Garcin, D.3
-
105
-
-
79953166075
-
Short double-stranded RNAs with an overhanging 5′ ppp-nucleotide, as found in arenavirus genomes, act as RIG-I decoys
-
Marq, J.-B., Hausmann, S., Veillard, N., Kolakofsky, D., Garcin, D., Short double-stranded RNAs with an overhanging 5′ ppp-nucleotide, as found in arenavirus genomes, act as RIG-I decoys. J. Biol. Chem. 286:8 (2011), 6108–6116.
-
(2011)
J. Biol. Chem.
, vol.286
, Issue.8
, pp. 6108-6116
-
-
Marq, J.-B.1
Hausmann, S.2
Veillard, N.3
Kolakofsky, D.4
Garcin, D.5
-
106
-
-
84953868013
-
Mismatches in the influenza A virus RNA panhandle prevent retinoic acid-inducible gene I (RIG-I) sensing by impairing RNA/RIG-I complex formation
-
Anchisi, S., Guerra, J., Mottet-Osman, G., Garcin, D., Mismatches in the influenza A virus RNA panhandle prevent retinoic acid-inducible gene I (RIG-I) sensing by impairing RNA/RIG-I complex formation. J. Virol. 90:1 (2016), 586–590.
-
(2016)
J. Virol.
, vol.90
, Issue.1
, pp. 586-590
-
-
Anchisi, S.1
Guerra, J.2
Mottet-Osman, G.3
Garcin, D.4
-
107
-
-
44349143815
-
Processing of genome 5′ termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction
-
Habjan, M., Andersson, I., Klingstrom, J., Schumann, M., Martin, A., Zimmermann, P., Wagner, V., Pichlmair, A., Schneider, U., Muhlberger, E., Mirazimi, A., Weber, F., Processing of genome 5′ termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction. PLoS ONE, 3(4), 2008, e2032.
-
(2008)
PLoS ONE
, vol.3
, Issue.4
, pp. e2032
-
-
Habjan, M.1
Andersson, I.2
Klingstrom, J.3
Schumann, M.4
Martin, A.5
Zimmermann, P.6
Wagner, V.7
Pichlmair, A.8
Schneider, U.9
Muhlberger, E.10
Mirazimi, A.11
Weber, F.12
-
108
-
-
84929374105
-
Innate immune restriction and antagonism of viral RNA lacking 2-O methylation
-
Hyde, J.L., Diamond, M.S., Innate immune restriction and antagonism of viral RNA lacking 2-O methylation. Virology 479–480 (2015), 66–74.
-
(2015)
Virology
, vol.479-480
, pp. 66-74
-
-
Hyde, J.L.1
Diamond, M.S.2
-
109
-
-
84955260823
-
Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I
-
Devarkar, S.C., Wang, C., Miller, M.T., Ramanathan, A., Jiang, F., Khan, A.G., Patel, S.S., Marcotrigiano, J., Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. Proc. Natl. Acad. Sci. USA 113:3 (2016), 596–601.
-
(2016)
Proc. Natl. Acad. Sci. USA
, vol.113
, Issue.3
, pp. 596-601
-
-
Devarkar, S.C.1
Wang, C.2
Miller, M.T.3
Ramanathan, A.4
Jiang, F.5
Khan, A.G.6
Patel, S.S.7
Marcotrigiano, J.8
-
110
-
-
33846863325
-
Mda-5, but not RIG-I, is a common target for paramyxovirus V proteins
-
Childs, K., Stock, N., Ross, C., Andrejeva, J., Hilton, L., Skinner, M., Randall, R., Goodbourn, S., Mda-5, but not RIG-I, is a common target for paramyxovirus V proteins. Virology 359:1 (2007), 190–200.
-
(2007)
Virology
, vol.359
, Issue.1
, pp. 190-200
-
-
Childs, K.1
Stock, N.2
Ross, C.3
Andrejeva, J.4
Hilton, L.5
Skinner, M.6
Randall, R.7
Goodbourn, S.8
-
111
-
-
84873523444
-
Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling
-
Motz, C., Schuhmann, K.M., Kirchhofer, A., Moldt, M., Witte, G., Conzelmann, K.K., Hopfner, K.P., Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling. Science 339:6120 (2013), 690–693.
-
(2013)
Science
, vol.339
, Issue.6120
, pp. 690-693
-
-
Motz, C.1
Schuhmann, K.M.2
Kirchhofer, A.3
Moldt, M.4
Witte, G.5
Conzelmann, K.K.6
Hopfner, K.P.7
-
112
-
-
84879408976
-
Structural mechanism of cytosolic DNA sensing by cGAS
-
Civril, F., Deimling, T., de Oliveira Mann, C.C., Ablasser, A., Moldt, M., Witte, G., Hornung, V., Hopfner, K.P., Structural mechanism of cytosolic DNA sensing by cGAS. Nature 498:7454 (2013), 332–337.
-
(2013)
Nature
, vol.498
, Issue.7454
, pp. 332-337
-
-
Civril, F.1
Deimling, T.2
de Oliveira Mann, C.C.3
Ablasser, A.4
Moldt, M.5
Witte, G.6
Hornung, V.7
Hopfner, K.P.8
-
113
-
-
84878592773
-
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity
-
Kranzusch, P.J., Lee, A.S., Berger, J.M., Doudna, J.A., Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep. 3:5 (2013), 1362–1368.
-
(2013)
Cell Rep.
, vol.3
, Issue.5
, pp. 1362-1368
-
-
Kranzusch, P.J.1
Lee, A.S.2
Berger, J.M.3
Doudna, J.A.4
-
114
-
-
84890235012
-
Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization
-
Li, X., Shu, C., Yi, G., Chaton, C.T., Shelton, C.L., Diao, J., Zuo, X., Kao, C.C., Herr, A.B., Li, P., Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. Immunity 39:6 (2013), 1019–1031.
-
(2013)
Immunity
, vol.39
, Issue.6
, pp. 1019-1031
-
-
Li, X.1
Shu, C.2
Yi, G.3
Chaton, C.T.4
Shelton, C.L.5
Diao, J.6
Zuo, X.7
Kao, C.C.8
Herr, A.B.9
Li, P.10
-
115
-
-
84893863593
-
The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop
-
Zhang, X., Wu, J., Du, F., Xu, H., Sun, L., Chen, Z., Brautigam, C.A., Zhang, X., Chen, Z.J., The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. Cell Rep. 6:3 (2014), 421–430.
-
(2014)
Cell Rep.
, vol.6
, Issue.3
, pp. 421-430
-
-
Zhang, X.1
Wu, J.2
Du, F.3
Xu, H.4
Sun, L.5
Chen, Z.6
Brautigam, C.A.7
Zhang, X.8
Chen, Z.J.9
-
116
-
-
84941954118
-
Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA
-
Herzner, A.M., Hagmann, C.A., Goldeck, M., Wolter, S., Kubler, K., Wittmann, S., Gramberg, T., Andreeva, L., Hopfner, K.P., Mertens, C., Zillinger, T., Jin, T., Xiao, T.S., Bartok, E., Coch, C., Ackermann, D., Hornung, V., Ludwig, J., Barchet, W., Hartmann, G., Schlee, M., Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA. Nat. Immunol. 16:10 (2015), 1025–1033.
-
(2015)
Nat. Immunol.
, vol.16
, Issue.10
, pp. 1025-1033
-
-
Herzner, A.M.1
Hagmann, C.A.2
Goldeck, M.3
Wolter, S.4
Kubler, K.5
Wittmann, S.6
Gramberg, T.7
Andreeva, L.8
Hopfner, K.P.9
Mertens, C.10
Zillinger, T.11
Jin, T.12
Xiao, T.S.13
Bartok, E.14
Coch, C.15
Ackermann, D.16
Hornung, V.17
Ludwig, J.18
Barchet, W.19
Hartmann, G.20
Schlee, M.21
more..
-
117
-
-
84918823623
-
Cytosolic RNA:DNA hybrids activate the cGAS-STING axis
-
Mankan, A.K., Schmidt, T., Chauhan, D., Goldeck, M., Honing, K., Gaidt, M., Kubarenko, A.V., Andreeva, L., Hopfner, K.P., Hornung, V., Cytosolic RNA:DNA hybrids activate the cGAS-STING axis. EMBO J. 33:24 (2014), 2937–2946.
-
(2014)
EMBO J.
, vol.33
, Issue.24
, pp. 2937-2946
-
-
Mankan, A.K.1
Schmidt, T.2
Chauhan, D.3
Goldeck, M.4
Honing, K.5
Gaidt, M.6
Kubarenko, A.V.7
Andreeva, L.8
Hopfner, K.P.9
Hornung, V.10
-
118
-
-
69249098278
-
The TLR-independent DNA recognition pathway in murine macrophages: ligand features and molecular signature
-
Karayel, E., Burckstummer, T., Bilban, M., Durnberger, G., Weitzer, S., Martinez, J., Superti-Furga, G., The TLR-independent DNA recognition pathway in murine macrophages: ligand features and molecular signature. Eur. J. Immunol. 39:7 (2009), 1929–1936.
-
(2009)
Eur. J. Immunol.
, vol.39
, Issue.7
, pp. 1929-1936
-
-
Karayel, E.1
Burckstummer, T.2
Bilban, M.3
Durnberger, G.4
Weitzer, S.5
Martinez, J.6
Superti-Furga, G.7
-
119
-
-
84884675857
-
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects
-
Li, X.D., Wu, J., Gao, D., Wang, H., Sun, L., Chen, Z.J., Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 341:6152 (2013), 1390–1394.
-
(2013)
Science
, vol.341
, Issue.6152
, pp. 1390-1394
-
-
Li, X.D.1
Wu, J.2
Gao, D.3
Wang, H.4
Sun, L.5
Chen, Z.J.6
-
120
-
-
84895904323
-
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
-
Schoggins, J.W., MacDuff, D.A., Imanaka, N., Gainey, M.D., Shrestha, B., Eitson, J.L., Mar, K.B., Richardson, R.B., Ratushny, A.V., Litvak, V., Dabelic, R., Manicassamy, B., Aitchison, J.D., Aderem, A., Elliott, R.M., Garcia-Sastre, A., Racaniello, V., Snijder, E.J., Yokoyama, W.M., Diamond, M.S., Virgin, H.W., Rice, C.M., Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 505:7485 (2014), 691–695.
-
(2014)
Nature
, vol.505
, Issue.7485
, pp. 691-695
-
-
Schoggins, J.W.1
MacDuff, D.A.2
Imanaka, N.3
Gainey, M.D.4
Shrestha, B.5
Eitson, J.L.6
Mar, K.B.7
Richardson, R.B.8
Ratushny, A.V.9
Litvak, V.10
Dabelic, R.11
Manicassamy, B.12
Aitchison, J.D.13
Aderem, A.14
Elliott, R.M.15
Garcia-Sastre, A.16
Racaniello, V.17
Snijder, E.J.18
Yokoyama, W.M.19
Diamond, M.S.20
Virgin, H.W.21
Rice, C.M.22
more..
-
121
-
-
84975229736
-
Diminished innate antiviral response to adenovirus vectors in cGAS/STING-deficient mice minimally impacts adaptive immunity
-
Anghelina, D., Lam, E., Falck-Pedersen, E., Diminished innate antiviral response to adenovirus vectors in cGAS/STING-deficient mice minimally impacts adaptive immunity. J. Virol. 90:13 (2016), 5915–5927.
-
(2016)
J. Virol.
, vol.90
, Issue.13
, pp. 5915-5927
-
-
Anghelina, D.1
Lam, E.2
Falck-Pedersen, E.3
-
122
-
-
84974728178
-
Type I interferon induction by Neisseria gonorrhoeae: dual requirement of cyclic GMP-AMP synthase and toll-like receptor 4
-
Andrade, W.A., Agarwal, S., Mo, S., Shaffer, S.A., Dillard, J.P., Schmidt, T., Hornung, V., Fitzgerald, K.A., Kurt-Jones, E.A., Golenbock, D.T., Type I interferon induction by Neisseria gonorrhoeae: dual requirement of cyclic GMP-AMP synthase and toll-like receptor 4. Cell Rep. 15:11 (2016), 2438–2448.
-
(2016)
Cell Rep.
, vol.15
, Issue.11
, pp. 2438-2448
-
-
Andrade, W.A.1
Agarwal, S.2
Mo, S.3
Shaffer, S.A.4
Dillard, J.P.5
Schmidt, T.6
Hornung, V.7
Fitzgerald, K.A.8
Kurt-Jones, E.A.9
Golenbock, D.T.10
-
123
-
-
70349943834
-
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
-
Ishikawa, H., Ma, Z., Barber, G.N., STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461:7265 (2009), 788–792.
-
(2009)
Nature
, vol.461
, Issue.7265
, pp. 788-792
-
-
Ishikawa, H.1
Ma, Z.2
Barber, G.N.3
-
124
-
-
84890215093
-
The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells
-
Lahaye, X., Satoh, T., Gentili, M., Cerboni, S., Conrad, C., Hurbain, I., El Marjou, A., Lacabaratz, C., Lelievre, J.D., Manel, N., The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells. Immunity 39:6 (2013), 1132–1142.
-
(2013)
Immunity
, vol.39
, Issue.6
, pp. 1132-1142
-
-
Lahaye, X.1
Satoh, T.2
Gentili, M.3
Cerboni, S.4
Conrad, C.5
Hurbain, I.6
El Marjou, A.7
Lacabaratz, C.8
Lelievre, J.D.9
Manel, N.10
-
125
-
-
84882896267
-
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
-
Gao, D., Wu, J., Wu, Y.T., Du, F., Aroh, C., Yan, N., Sun, L., Chen, Z.J., Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 341:6148 (2013), 903–906.
-
(2013)
Science
, vol.341
, Issue.6148
, pp. 903-906
-
-
Gao, D.1
Wu, J.2
Wu, Y.T.3
Du, F.4
Aroh, C.5
Yan, N.6
Sun, L.7
Chen, Z.J.8
-
126
-
-
84888054227
-
HIV-1 evades innate immune recognition through specific cofactor recruitment
-
Rasaiyaah, J., Tan, C.P., Fletcher, A.J., Price, A.J., Blondeau, C., Hilditch, L., Jacques, D.A., Selwood, D.L., James, L.C., Noursadeghi, M., Towers, G.J., HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature 503:7476 (2013), 402–405.
-
(2013)
Nature
, vol.503
, Issue.7476
, pp. 402-405
-
-
Rasaiyaah, J.1
Tan, C.P.2
Fletcher, A.J.3
Price, A.J.4
Blondeau, C.5
Hilditch, L.6
Jacques, D.A.7
Selwood, D.L.8
James, L.C.9
Noursadeghi, M.10
Towers, G.J.11
-
127
-
-
84947245185
-
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
-
Gao, D., Li, T., Li, X.D., Chen, X., Li, Q.Z., Wight-Carter, M., Chen, Z.J., Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. Proc. Natl. Acad. Sci. USA 112:42 (2015), E5699–E56705.
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, Issue.42
, pp. E5699-E56705
-
-
Gao, D.1
Li, T.2
Li, X.D.3
Chen, X.4
Li, Q.Z.5
Wight-Carter, M.6
Chen, Z.J.7
-
128
-
-
84896332642
-
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
-
Lu, A., Magupalli, V.G., Ruan, J., Yin, Q., Atianand, M.K., Vos, M.R., Schroder, G.F., Fitzgerald, K.A., Wu, H., Egelman, E.H., Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell 156:6 (2014), 1193–1206.
-
(2014)
Cell
, vol.156
, Issue.6
, pp. 1193-1206
-
-
Lu, A.1
Magupalli, V.G.2
Ruan, J.3
Yin, Q.4
Atianand, M.K.5
Vos, M.R.6
Schroder, G.F.7
Fitzgerald, K.A.8
Wu, H.9
Egelman, E.H.10
-
129
-
-
84937902109
-
Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC
-
Morrone, S.R., Matyszewski, M., Yu, X., Delannoy, M., Egelman, E.H., Sohn, J., Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC. Nat. Commun., 6, 2015, 7827.
-
(2015)
Nat. Commun.
, vol.6
, pp. 7827
-
-
Morrone, S.R.1
Matyszewski, M.2
Yu, X.3
Delannoy, M.4
Egelman, E.H.5
Sohn, J.6
-
130
-
-
84859986329
-
Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
-
Jin, T., Perry, A., Jiang, J., Smith, P., Curry, J.A., Unterholzner, L., Jiang, Z., Horvath, G., Rathinam, V.A., Johnstone, R.W., Hornung, V., Latz, E., Bowie, A.G., Fitzgerald, K.A., Xiao, T.S., Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 36:4 (2012), 561–571.
-
(2012)
Immunity
, vol.36
, Issue.4
, pp. 561-571
-
-
Jin, T.1
Perry, A.2
Jiang, J.3
Smith, P.4
Curry, J.A.5
Unterholzner, L.6
Jiang, Z.7
Horvath, G.8
Rathinam, V.A.9
Johnstone, R.W.10
Hornung, V.11
Latz, E.12
Bowie, A.G.13
Fitzgerald, K.A.14
Xiao, T.S.15
-
131
-
-
84891933102
-
Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy
-
Morrone, S.R., Wang, T., Constantoulakis, L.M., Hooy, R.M., Delannoy, M.J., Sohn, J., Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy. Proc. Natl. Acad. Sci. USA 111:1 (2014), E62–E71.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, Issue.1
, pp. E62-E71
-
-
Morrone, S.R.1
Wang, T.2
Constantoulakis, L.M.3
Hooy, R.M.4
Delannoy, M.J.5
Sohn, J.6
-
132
-
-
52449135474
-
RPA nucleic acid-binding properties of IFI16-HIN200
-
Yan, H., Dalal, K., Hon, B.K., Youkharibache, P., Lau, D., Pio, F., RPA nucleic acid-binding properties of IFI16-HIN200. Biochim. Biophys. Acta 1784:7–8 (2008), 1087–1097.
-
(2008)
Biochim. Biophys. Acta
, vol.1784
, Issue.7-8
, pp. 1087-1097
-
-
Yan, H.1
Dalal, K.2
Hon, B.K.3
Youkharibache, P.4
Lau, D.5
Pio, F.6
-
133
-
-
84975523516
-
IFI16 preferentially binds to DNA with quadruplex structure and enhances DNA quadruplex formation
-
Haronikova, L., Coufal, J., Kejnovska, I., Jagelska, E.B., Fojta, M., Dvorakova, P., Muller, P., Vojtesek, B., Brazda, V., IFI16 preferentially binds to DNA with quadruplex structure and enhances DNA quadruplex formation. PLoS ONE, 11(6), 2016, e0157156.
-
(2016)
PLoS ONE
, vol.11
, Issue.6
, pp. e0157156
-
-
Haronikova, L.1
Coufal, J.2
Kejnovska, I.3
Jagelska, E.B.4
Fojta, M.5
Dvorakova, P.6
Muller, P.7
Vojtesek, B.8
Brazda, V.9
-
134
-
-
84862279094
-
Preferential binding of IFI16 protein to cruciform structure and superhelical DNA
-
Brazda, V., Coufal, J., Liao, J.C., Arrowsmith, C.H., Preferential binding of IFI16 protein to cruciform structure and superhelical DNA. Biochem. Biophys. Res. Commun. 422:4 (2012), 716–720.
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.422
, Issue.4
, pp. 716-720
-
-
Brazda, V.1
Coufal, J.2
Liao, J.C.3
Arrowsmith, C.H.4
-
135
-
-
84988646188
-
The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex
-
Stratmann, S.A., Morrone, S.R., van Oijen, A.M., Sohn, J., The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex. eLife, 4, 2015.
-
(2015)
eLife
, vol.4
-
-
Stratmann, S.A.1
Morrone, S.R.2
van Oijen, A.M.3
Sohn, J.4
-
136
-
-
84876334378
-
Herpes simplex virus 1 infection induces activation and subsequent inhibition of the IFI16 and NLRP3 inflammasomes
-
Johnson, K.E., Chikoti, L., Chandran, B., Herpes simplex virus 1 infection induces activation and subsequent inhibition of the IFI16 and NLRP3 inflammasomes. J. Virol. 87:9 (2013), 5005–5018.
-
(2013)
J. Virol.
, vol.87
, Issue.9
, pp. 5005-5018
-
-
Johnson, K.E.1
Chikoti, L.2
Chandran, B.3
-
137
-
-
84938805575
-
Herpesvirus genome recognition induced acetylation of nuclear IFI16 is essential for its cytoplasmic translocation, inflammasome and IFN-beta responses
-
Ansari, M.A., Dutta, S., Veettil, M.V., Dutta, D., Iqbal, J., Kumar, B., Roy, A., Chikoti, L., Singh, V.V., Chandran, B., Herpesvirus genome recognition induced acetylation of nuclear IFI16 is essential for its cytoplasmic translocation, inflammasome and IFN-beta responses. PLoS Pathog., 11(7), 2015, e1005019.
-
(2015)
PLoS Pathog.
, vol.11
, Issue.7
, pp. e1005019
-
-
Ansari, M.A.1
Dutta, S.2
Veettil, M.V.3
Dutta, D.4
Iqbal, J.5
Kumar, B.6
Roy, A.7
Chikoti, L.8
Singh, V.V.9
Chandran, B.10
-
138
-
-
84896517722
-
Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA
-
Chiliveru, S., Rahbek, S.H., Jensen, S.K., Jorgensen, S.E., Nissen, S.K., Christiansen, S.H., Mogensen, T.H., Jakobsen, M.R., Iversen, L., Johansen, C., Paludan, S.R., Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA. J. Immunol. 192:5 (2014), 2395–2404.
-
(2014)
J. Immunol.
, vol.192
, Issue.5
, pp. 2395-2404
-
-
Chiliveru, S.1
Rahbek, S.H.2
Jensen, S.K.3
Jorgensen, S.E.4
Nissen, S.K.5
Christiansen, S.H.6
Mogensen, T.H.7
Jakobsen, M.R.8
Iversen, L.9
Johansen, C.10
Paludan, S.R.11
-
139
-
-
84956825823
-
AIM2 inflammasome in infection, cancer, and autoimmunity: role in DNA sensing, inflammation, and innate immunity
-
Man, S.M., Karki, R., Kanneganti, T.D., AIM2 inflammasome in infection, cancer, and autoimmunity: role in DNA sensing, inflammation, and innate immunity. Eur. J. Immunol. 46:2 (2016), 269–280.
-
(2016)
Eur. J. Immunol.
, vol.46
, Issue.2
, pp. 269-280
-
-
Man, S.M.1
Karki, R.2
Kanneganti, T.D.3
-
140
-
-
77951269392
-
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
-
Rathinam, V.A., Jiang, Z., Waggoner, S.N., Sharma, S., Cole, L.E., Waggoner, L., Vanaja, S.K., Monks, B.G., Ganesan, S., Latz, E., Hornung, V., Vogel, S.N., Szomolanyi-Tsuda, E., Fitzgerald, K.A., The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol. 11:5 (2010), 395–402.
-
(2010)
Nat. Immunol.
, vol.11
, Issue.5
, pp. 395-402
-
-
Rathinam, V.A.1
Jiang, Z.2
Waggoner, S.N.3
Sharma, S.4
Cole, L.E.5
Waggoner, L.6
Vanaja, S.K.7
Monks, B.G.8
Ganesan, S.9
Latz, E.10
Hornung, V.11
Vogel, S.N.12
Szomolanyi-Tsuda, E.13
Fitzgerald, K.A.14
-
141
-
-
77951263260
-
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
-
Fernandes-Alnemri, T., Yu, J.W., Juliana, C., Solorzano, L., Kang, S., Wu, J., Datta, P., McCormick, M., Huang, L., McDermott, E., Eisenlohr, L., Landel, C.P., Alnemri, E.S., The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat. Immunol. 11:5 (2010), 385–393.
-
(2010)
Nat. Immunol.
, vol.11
, Issue.5
, pp. 385-393
-
-
Fernandes-Alnemri, T.1
Yu, J.W.2
Juliana, C.3
Solorzano, L.4
Kang, S.5
Wu, J.6
Datta, P.7
McCormick, M.8
Huang, L.9
McDermott, E.10
Eisenlohr, L.11
Landel, C.P.12
Alnemri, E.S.13
-
142
-
-
84867136602
-
Critical role of AIM2 in Mycobacterium tuberculosis infection
-
Saiga, H., Kitada, S., Shimada, Y., Kamiyama, N., Okuyama, M., Makino, M., Yamamoto, M., Takeda, K., Critical role of AIM2 in Mycobacterium tuberculosis infection. Int. Immunol. 24:10 (2012), 637–644.
-
(2012)
Int. Immunol.
, vol.24
, Issue.10
, pp. 637-644
-
-
Saiga, H.1
Kitada, S.2
Shimada, Y.3
Kamiyama, N.4
Okuyama, M.5
Makino, M.6
Yamamoto, M.7
Takeda, K.8
-
143
-
-
84875431649
-
Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection
-
Gomes, M.T., Campos, P.C., Oliveira, F.S., Corsetti, P.P., Bortoluci, K.R., Cunha, L.D., Zamboni, D.S., Oliveira, S.C., Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection. J. Immunol. 190:7 (2013), 3629–3638.
-
(2013)
J. Immunol.
, vol.190
, Issue.7
, pp. 3629-3638
-
-
Gomes, M.T.1
Campos, P.C.2
Oliveira, F.S.3
Corsetti, P.P.4
Bortoluci, K.R.5
Cunha, L.D.6
Zamboni, D.S.7
Oliveira, S.C.8
-
144
-
-
84899474093
-
Critical role for the AIM2 inflammasome during acute CNS bacterial infection
-
Hanamsagar, R., Aldrich, A., Kielian, T., Critical role for the AIM2 inflammasome during acute CNS bacterial infection. J. Neurochem. 129:4 (2014), 704–711.
-
(2014)
J. Neurochem.
, vol.129
, Issue.4
, pp. 704-711
-
-
Hanamsagar, R.1
Aldrich, A.2
Kielian, T.3
-
145
-
-
84925841637
-
cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection
-
Storek, K.M., Gertsvolf, N.A., Ohlson, M.B., Monack, D.M., cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection. J. Immunol. 194:7 (2015), 3236–3245.
-
(2015)
J. Immunol.
, vol.194
, Issue.7
, pp. 3236-3245
-
-
Storek, K.M.1
Gertsvolf, N.A.2
Ohlson, M.B.3
Monack, D.M.4
-
146
-
-
84926164932
-
Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against aspergillus infection
-
Karki, R., Man, Si.M., Malireddi, R.K.S., Gurung, P., Vogel, P., Lamkanfi, M., Kanneganti, T.-D., Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against aspergillus infection. Cell Host Microbe 17:3 (2015), 357–368.
-
(2015)
Cell Host Microbe
, vol.17
, Issue.3
, pp. 357-368
-
-
Karki, R.1
Man, S.M.2
Malireddi, R.K.S.3
Gurung, P.4
Vogel, P.5
Lamkanfi, M.6
Kanneganti, T.-D.7
-
147
-
-
84892552656
-
Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria
-
Kalantari, P., DeOliveira, R.B., Chan, J., Corbett, Y., Rathinam, V., Stutz, A., Latz, E., Gazzinelli, R.T., Golenbock, D.T., Fitzgerald, K.A., Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria. Cell Rep. 6:1 (2014), 196–210.
-
(2014)
Cell Rep.
, vol.6
, Issue.1
, pp. 196-210
-
-
Kalantari, P.1
DeOliveira, R.B.2
Chan, J.3
Corbett, Y.4
Rathinam, V.5
Stutz, A.6
Latz, E.7
Gazzinelli, R.T.8
Golenbock, D.T.9
Fitzgerald, K.A.10
-
148
-
-
84863116708
-
Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16
-
Conrady, C.D., Zheng, M., Fitzgerald, K.A., Liu, C., Carr, D.J., Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16. Mucosal Immunol. 5:2 (2012), 173–183.
-
(2012)
Mucosal Immunol.
, vol.5
, Issue.2
, pp. 173-183
-
-
Conrady, C.D.1
Zheng, M.2
Fitzgerald, K.A.3
Liu, C.4
Carr, D.J.5
-
149
-
-
84887929864
-
Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion
-
Li, T., Chen, J., Cristea, I.M., Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion. Cell Host Microbe 14:5 (2013), 591–599.
-
(2013)
Cell Host Microbe
, vol.14
, Issue.5
, pp. 591-599
-
-
Li, T.1
Chen, J.2
Cristea, I.M.3
-
150
-
-
84857477766
-
The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication
-
Gariano, G.R., Dell'Oste, V., Bronzini, M., Gatti, D., Luganini, A., De Andrea, M., Gribaudo, G., Gariglio, M., Landolfo, S., The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication. PLoS Pathog., 8(1), 2012, e1002498.
-
(2012)
PLoS Pathog.
, vol.8
, Issue.1
, pp. e1002498
-
-
Gariano, G.R.1
Dell'Oste, V.2
Bronzini, M.3
Gatti, D.4
Luganini, A.5
De Andrea, M.6
Gribaudo, G.7
Gariglio, M.8
Landolfo, S.9
-
151
-
-
84875800370
-
Kaposi's sarcoma-associated herpesvirus latency in endothelial and B cells activates gamma interferon-inducible protein 16-mediated inflammasomes
-
Singh, V.V., Kerur, N., Bottero, V., Dutta, S., Chakraborty, S., Ansari, M.A., Paudel, N., Chikoti, L., Chandran, B., Kaposi's sarcoma-associated herpesvirus latency in endothelial and B cells activates gamma interferon-inducible protein 16-mediated inflammasomes. J. Virol. 87:8 (2013), 4417–4431.
-
(2013)
J. Virol.
, vol.87
, Issue.8
, pp. 4417-4431
-
-
Singh, V.V.1
Kerur, N.2
Bottero, V.3
Dutta, S.4
Chakraborty, S.5
Ansari, M.A.6
Paudel, N.7
Chikoti, L.8
Chandran, B.9
-
152
-
-
84880617721
-
Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells
-
Ansari, M.A., Singh, V.V., Dutta, S., Veettil, M.V., Dutta, D., Chikoti, L., Lu, J., Everly, D., Chandran, B., Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells. J. Virol. 87:15 (2013), 8606–8623.
-
(2013)
J. Virol.
, vol.87
, Issue.15
, pp. 8606-8623
-
-
Ansari, M.A.1
Singh, V.V.2
Dutta, S.3
Veettil, M.V.4
Dutta, D.5
Chikoti, L.6
Lu, J.7
Everly, D.8
Chandran, B.9
-
153
-
-
84892946076
-
IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV
-
Monroe, K.M., Yang, Z., Johnson, J.R., Geng, X., Doitsh, G., Krogan, N.J., Greene, W.C., IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science 343:6169 (2014), 428–432.
-
(2014)
Science
, vol.343
, Issue.6169
, pp. 428-432
-
-
Monroe, K.M.1
Yang, Z.2
Johnson, J.R.3
Geng, X.4
Doitsh, G.5
Krogan, N.J.6
Greene, W.C.7
-
154
-
-
84927159089
-
Inflammasome signaling pathways exert antiviral effect against Chikungunya virus in human dermal fibroblasts
-
Ekchariyawat, P., Hamel, R., Bernard, E., Wichit, S., Surasombatpattana, P., Talignani, L., Thomas, F., Choumet, V., Yssel, H., Despres, P., Briant, L., Misse, D., Inflammasome signaling pathways exert antiviral effect against Chikungunya virus in human dermal fibroblasts. Infect., Genet. Evol.: J. Mol. Epidemiol. Evol. Genet. Infect. Dis. 32 (2015), 401–408.
-
(2015)
Infect., Genet. Evol.: J. Mol. Epidemiol. Evol. Genet. Infect. Dis.
, vol.32
, pp. 401-408
-
-
Ekchariyawat, P.1
Hamel, R.2
Bernard, E.3
Wichit, S.4
Surasombatpattana, P.5
Talignani, L.6
Thomas, F.7
Choumet, V.8
Yssel, H.9
Despres, P.10
Briant, L.11
Misse, D.12
-
155
-
-
84875249328
-
A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries
-
Vannini, A., A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries. Biochim. Biophys. Acta 1829:3–4 (2013), 258–264.
-
(2013)
Biochim. Biophys. Acta
, vol.1829
, Issue.3-4
, pp. 258-264
-
-
Vannini, A.1
-
156
-
-
12344306120
-
Rpc25, a conserved RNA polymerase III subunit, is critical for transcription initiation
-
Zaros, C., Thuriaux, P., Rpc25, a conserved RNA polymerase III subunit, is critical for transcription initiation. Mol. Microbiol. 55:1 (2005), 104–114.
-
(2005)
Mol. Microbiol.
, vol.55
, Issue.1
, pp. 104-114
-
-
Zaros, C.1
Thuriaux, P.2
-
157
-
-
0019770963
-
Striking similarities are exhibited by two small Epstein-Barr virus-encoded ribonucleic acids and the adenovirus-associated ribonucleic acids VAI and VAII
-
Rosa, M.D., Gottlieb, E., Lerner, M.R., Steitz, J.A., Striking similarities are exhibited by two small Epstein-Barr virus-encoded ribonucleic acids and the adenovirus-associated ribonucleic acids VAI and VAII. Mol. Cell. Biol. 1:9 (1981), 785–796.
-
(1981)
Mol. Cell. Biol.
, vol.1
, Issue.9
, pp. 785-796
-
-
Rosa, M.D.1
Gottlieb, E.2
Lerner, M.R.3
Steitz, J.A.4
-
158
-
-
0019444924
-
Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus
-
Lerner, M.R., Andrews, N.C., Miller, G., Steitz, J.A., Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus. Proc. Natl. Acad. Sci. USA 78:2 (1981), 805–809.
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, Issue.2
, pp. 805-809
-
-
Lerner, M.R.1
Andrews, N.C.2
Miller, G.3
Steitz, J.A.4
-
159
-
-
79952836011
-
Adenovirus virus-associated RNAs induce type I interferon expression through a RIG-I-mediated pathway
-
Minamitani, T., Iwakiri, D., Takada, K., Adenovirus virus-associated RNAs induce type I interferon expression through a RIG-I-mediated pathway. J. Virol. 85:8 (2011), 4035–4040.
-
(2011)
J. Virol.
, vol.85
, Issue.8
, pp. 4035-4040
-
-
Minamitani, T.1
Iwakiri, D.2
Takada, K.3
-
160
-
-
84943584568
-
RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1
-
Crill, E.K., Furr-Rogers, S.R., Marriott, I., RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1. Glia 63:12 (2015), 2168–2180.
-
(2015)
Glia
, vol.63
, Issue.12
, pp. 2168-2180
-
-
Crill, E.K.1
Furr-Rogers, S.R.2
Marriott, I.3
-
161
-
-
70449584559
-
A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA
-
Choi, M.K., Wang, Z., Ban, T., Yanai, H., Lu, Y., Koshiba, R., Nakaima, Y., Hangai, S., Savitsky, D., Nakasato, M., Negishi, H., Takeuchi, O., Honda, K., Akira, S., Tamura, T., Taniguchi, T., A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA. Proc. Natl. Acad. Sci. USA 106:42 (2009), 17870–17875.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, Issue.42
, pp. 17870-17875
-
-
Choi, M.K.1
Wang, Z.2
Ban, T.3
Yanai, H.4
Lu, Y.5
Koshiba, R.6
Nakaima, Y.7
Hangai, S.8
Savitsky, D.9
Nakasato, M.10
Negishi, H.11
Takeuchi, O.12
Honda, K.13
Akira, S.14
Tamura, T.15
Taniguchi, T.16
-
162
-
-
77957958023
-
Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways
-
Melchjorsen, J., Rintahaka, J., Soby, S., Horan, K.A., Poltajainen, A., Ostergaard, L., Paludan, S.R., Matikainen, S., Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways. J. Virol. 84:21 (2010), 11350–11358.
-
(2010)
J. Virol.
, vol.84
, Issue.21
, pp. 11350-11358
-
-
Melchjorsen, J.1
Rintahaka, J.2
Soby, S.3
Horan, K.A.4
Poltajainen, A.5
Ostergaard, L.6
Paludan, S.R.7
Matikainen, S.8
-
163
-
-
84866151928
-
IFNgamma inhibits the cytosolic replication of Shigella flexneri via the cytoplasmic RNA sensor RIG-I
-
Jehl, S.P., Nogueira, C.V., Zhang, X., Starnbach, M.N., IFNgamma inhibits the cytosolic replication of Shigella flexneri via the cytoplasmic RNA sensor RIG-I. PLoS Pathog., 8(8), 2012, e1002809.
-
(2012)
PLoS Pathog.
, vol.8
, Issue.8
, pp. e1002809
-
-
Jehl, S.P.1
Nogueira, C.V.2
Zhang, X.3
Starnbach, M.N.4
|