Structural mechanism of cytosolic DNA sensing by cGAS

Nature

Volumn 498, Issue 7454, 2013, Pages 332-337

  Civril, Filiz ^a   Deimling, Tobias ^a   De Oliveira Mann, Carina C ^a   Ablasser, Andrea ^b   Moldt, Manuela ^a   Witte, Gregor ^a   Hornung, Veit ^b   Hopfner, Karl Peter ^a,c  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c Munich Center for Integrated Protein Science   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; ADENOSINE TRIPHOSPHATE; CYCLIC AMP DERIVATIVE; CYCLIC GMP AMP SYNTHASE; CYCLIC GMP DERIVATIVE; DINUCLEOTIDE; DNA; DOUBLE STRANDED RNA; GUANOSINE TRIPHOSPHATE; NUCLEOTIDYLTRANSFERASE; UNCLASSIFIED DRUG;

CRYSTAL STRUCTURE; DNA; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNE RESPONSE;

ARTICLE; CATALYST; CRYSTAL STRUCTURE; DNA BINDING; ENZYME ACTIVATION; ENZYME SPECIFICITY; HUMAN; IN VITRO STUDY; INNATE IMMUNITY; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; BASE SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTOSOL; DNA; GUANOSINE TRIPHOSPHATE; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MICE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTATION; NUCLEOTIDYLTRANSFERASES; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SWINE; URIDINE TRIPHOSPHATE; ZINC;

BACTERIA (MICROORGANISMS);

EID: 84879408976     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12305     Document Type: Article

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