MDA5 assembles into a polar helical filament on dsRNA

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 45, 2012, Pages 18437-18441

  Berke, Ian C ^a   Yu, Xiong ^b   Modis, Yorgo ^a   Egelman, Edward H ^b  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

DExD H box RNA helicase; Innate immune receptor; Ligand binding cooperativity; Nucleic acid sensor; Prion like switch

Indexed keywords

DOUBLE STRANDED RNA; MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN 5; MITOCHONDRIAL ANTIVIRAL SIGNALING PROTEIN; ONCOPROTEIN; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG;

ARTICLE; ELECTRON MICROSCOPY; FIBER; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE;

ADENOSINE TRIPHOSPHATE; ANIMALS; DEAD-BOX RNA HELICASES; HEK293 CELLS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICE; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 84868538362     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1212186109     Document Type: Article

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