Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

Science

Volumn 341, Issue 6148, 2013, Pages 903-906

  Gao, Daxing ^a   Wu, Jiaxi ^a   Wu, You Tong ^a   Du, Fenghe ^a   Aroh, Chukwuemika ^b   Yan, Nan ^b   Sun, Lijun ^a   Chen, Zhijian J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYCLIC GUANOSINE MONOPHOSPHATE ADENOSINE MONOPHOSPHATE SYNTHASE; CYTOKINE; INTEGRASE; INTERFERON; NEVIRAPINE; PEPTIDES AND PROTEINS; PROTEIN STING; RALTEGRAVIR; RNA DIRECTED DNA POLYMERASE; SYNTHETASE; UNCLASSIFIED DRUG; ZIDOVUDINE;

DNA; ENZYME; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; PROTEIN; SENSOR; VIRUS;

ARTICLE; ENZYME INHIBITION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS;

MURINE LEUKEMIA VIRUS; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 84882896267     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1240933     Document Type: Article

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21. 217) amino acids in the catalytic domain, respectively. For details, see materials and methods in the supplementary materials.