Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

Cell Reports

Volumn 3, Issue 5, 2013, Pages 1362-1368

  Kranzusch, PhilipJ ^a   Lee, AmySi Ying ^a   Berger, JamesM ^a,b   Doudna, JenniferA ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; CYCLIC GMP AMP SYNTHASE; DNA; SYNTHETASE; UNCLASSIFIED DRUG; INTERFERON; MB21D1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE; PROTEIN BINDING; RECOMBINANT PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; INNATE IMMUNITY; MOLECULAR RECOGNITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; BIOCATALYSIS; BIOSYNTHESIS; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR GENETICS; SECOND MESSENGER; X RAY CRYSTALLOGRAPHY;

2',5'-OLIGOADENYLATE SYNTHETASE; AMINO ACID SEQUENCE; BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INTERFERONS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NUCLEOTIDYLTRANSFERASES; PROTEIN BINDING; RECOMBINANT PROTEINS; SECOND MESSENGER SYSTEMS;

EID: 84878592773     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.05.008     Document Type: Article

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