Mitochondrial DNA stress primes the antiviral innate immune response

Nature

Volumn 520, Issue 7548, 2015, Pages 553-557

  West, A Phillip ^a   Khoury Hanold, William ^a   Staron, Matthew ^a   Tal, Michal C ^a,e   Pineda, Cristiana M ^a   Lang, Sabine M ^a   Bestwick, Megan ^a,f   Duguay, Brett A ^b   Raimundo, Nuno ^a,g   MacDuff, Donna A ^c   Kaech, Susan M ^a,d   Smiley, James R ^b   Means, Robert E ^a   Iwasaki, Akiko ^a,d   Shadel, Gerald S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f LINFIELD COLLEGE   (United States)

^g UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; INTERFERON; INTERFERON REGULATORY FACTOR 3; MITOCHONDRIAL DNA; DNA BINDING PROTEIN; HIGH MOBILITY GROUP PROTEIN; IRF3 PROTEIN, MOUSE; MB21D1 PROTEIN, MOUSE; MEMBRANE PROTEIN; MPYS PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE; TFAM PROTEIN, MOUSE;

ANTIMICROBIAL ACTIVITY; GENE EXPRESSION; HOMEOSTASIS; IMMUNE RESPONSE; MITOCHONDRIAL DNA; PROTEIN; PUBLIC HEALTH; VIRUS;

ARTICLE; CONTROLLED STUDY; DNA PACKAGING; GENE EXPRESSION; HERPESVIRIDAE; HUMAN; INNATE IMMUNITY; METABOLISM; MITOCHONDRIAL DNA DEPLETION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DEFICIENCY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HERPES SIMPLEX VIRUS 1; IMMUNOLOGY; MOUSE; PHYSIOLOGICAL STRESS;

ANIMALS; CELL LINE; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION; HERPESVIRUS 1, HUMAN; HIGH MOBILITY GROUP PROTEINS; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTOR-3; INTERFERON TYPE I; MEMBRANE PROTEINS; MICE; NUCLEOTIDYLTRANSFERASES; STRESS, PHYSIOLOGICAL;

EID: 84928537166     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14156     Document Type: Article

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