Viral infection switches non-plasmacytoid dendritic cells into high interferon producers

Nature

Volumn 424, Issue 6946, 2003, Pages 324-328

  Diebold, Sandra S ^a   Montoya, Maria ^b   Unger, Hermann ^c   Alexopoulou, Lena ^d   Roy, Polly ^e   Haswell, Linsey E ^f   Al Shamkhani, Aymen ^f   Flavell, Richard ^d   Borrow, Persephone ^b   Reis e Sousa, Caetano ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b EDWARD JENNER INST FOR VACC RES   (United Kingdom)

^c UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^f SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CHEMICAL ACTIVATION; ENZYMES; RNA; VIRUSES;

VIRAL INFECTION;

CELLS;

ALPHA INTERFERON; CYTOKINE; DOUBLE STRANDED RNA; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERFERON; INTERLEUKIN 12; POLYINOSINIC POLYCYTIDYLIC ACID; CELL SURFACE RECEPTOR; MEMBRANE PROTEIN; PROTEIN KINASE R; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3;

MEDICINE; VIRAL DISEASE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL TYPE; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; IMMUNE RESPONSE; INFLUENZA VIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CELL STRAIN 3T3; CPG ISLAND; GENETICS; IMMUNOLOGY; METABOLISM; SIGNAL TRANSDUCTION; VIRUS MENINGITIS;

ANIMALIA; ESCHERICHIA COLI; INFLUENZA VIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; STAPHYLOCOCCUS PHAGE 3A;

3T3 CELLS; ANIMALS; CPG ISLANDS; DENDRITIC CELLS; EIF-2 KINASE; INTERFERON TYPE I; INTERFERON-ALPHA; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RECEPTORS, CELL SURFACE; RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTORS;

EID: 0042307304     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01783     Document Type: Article

References (30)

1. Le Bon, A. & Tough, D. F. Links between innate and adaptive immunity via type I interferon. Curr. Opin. Immunol. 14, 432-436 (2002).
2. Colonna, M., Krug, A. & Cella, M. Interferon-producing cells: on the front line in immune responses against pathogens. Curr. Opin. Immunol. 14, 373-379 (2002).
3. Jacobs, B. L. & Langland, J. O. When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology 219, 339-349 (1996).
4. Williams, B. R. Signal integration via PKR. Sci. STKE 2001(89), RE2 (2001); at (http:// stke.sciencemag.org/cgi/content/full/OC_sigtrans;2001_89/re2).
5. Alexopoulou, L., Holt, A. C., Medzhitov, R. & Flavell, R. A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413, 732-738 (2001).
6. Garcia-Sastre, A. et al. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 252, 324-330 (1998).
7. Bergmann, M. et al. Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication, J. Virol. 74, 6203-6206 (2000).
8. Dalod, M. et al. Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo. J. Exp. Med. 195, 517-528 (2002).
9. Borrow, P., Evans, C. F. & Oldstone, M. B. Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression. J. Virol. 69, 1059-1070 (1995).
10. Katze, M. G., He, Y. & Gale, M. Viruses and interferon: A fight for supremacy. Nature Rev. Immunol. 2, 675-687 (2002).
11. Hochrein, H. et al. Differential production of IL-12, IFN-α, and IFN-γ by mouse dendritic cell subsets. J. Immunol. 166, 5448-5455 (2001).
12. Edwards, A. D. et al. Microbial recognition via toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering. J. Immunol. 169, 3652-3660 (2002).
13. Adachi, O. et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9, 143-150 (1998).
14. Horng, T., Barton, G. M. & Medzhitov, R. TIRAP: an adapter molecule in the Toll signaling pathway. Nature Immunol. 2, 835-841 (2001).
15. Balachandran, S. et al. Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. Immunity 13, 129-141 (2000).
16. Marcus, P. I. & Sekellick, M. J. Interferon induction by viruses. XV1. 2-Aminopurine blocks selectively and reversibly an early stage in interferon induction. J. Gen. Virol. 69, 1637-1645 (1988).
17. Zinn, K., Keller, A., Whittemore, L. A. & Maniatis, T. 2-Aminopurine selectively inhibits the induction of β-interferon, c-fos, and c-myc gene expression. Science 240, 210-213 (1988).
18. Yang, Y. L. et al. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J. 14, 6095-6106 (1995).
19. Smith, E. J., Marie, I., Prakash, A., Garcia-Sastre, A. & Levy, D. E. IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or IκB kinase but is blocked by Vaccinia virus E3L protein. J. Biol. Chem. 276, 8951-8957 (2001).
20. Cousens, L. P., Orange, J. S., Su, H. C. & Biron, C. A. Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection. Proc. Natl Acad. Sci. USA 94, 634-639 (1997).
21. Cella, M. et al. Plasmacytoid monocytes migrate to inflamed lmyph nodes and produce large amounts of type I interferon. Nature Med. 5, 919-923 (1999).
22. Kadowaki, N., Antonenko, S., Lau, J. Y. & Liu, Y. J. Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J. Exp. Med. 192, 219-226 (2000).
23. Nakano, H., Yanagita, M. & Gunn, M. D. Cd11c(+)b220(+)gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 194, 1171-1178 (2001).
24. Bruno, L., Seidl, T. & Lanzavecchia, A. Mouse pre-immunocytes as non-proliferating multipotent precursors of macrophages, interferon-producing cells, CD8α(+) and CD8α(-) dendritic cells. Eur. J. Immunol. 31, 3403-3412 (2001).
25. O'Keeffe, M. et al. Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus. J. Exp. Med 196, 1307-1319 (2002).
26. Siegal, F. P. et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 284, 1835-1837 (1999).
27. Asselin-Paturel, C. et al. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nature Immunol. 2, 1144-1150 (2001).
28. Marie, I., Durbin, J. E. & Levy, D. E. Differential viral induction of distinct interferon-α genes by positive feedback through interferon regulatory factor-7. EMBO J. 17, 6660-6669 (1998).
29. + DC correlates with unresponsiveness to imidazoquinolines. Eur. J. Immunol. 33, 827-833 (2003).
30. van den Hoff, M. J., Christoffels, V. M., Labruyere, W. T., Moorman, A. F. & Lamers, W. H. Electrotransfection with "intracellular" buffer. Methods Mol. Biol. 48, 185-197 (1995).