Diminished innate antiviral response to adenovirus vectors in cGAS/STING-deficient mice minimally impacts adaptive immunity

Journal of Virology

Volumn 90, Issue 13, 2016, Pages 5915-5927

  Anghelina, Daniela ^a,b   Lam, Eric ^a,c   Falck Pedersen, Erik ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

^c NEW YORK INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ADENOVIRUS VECTOR; BETA INTERFERON; CYCLIC GUANINE ADENINE SYNTHASE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; NEUTRALIZING ANTIBODY; STING ADAPTOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS DNA; CHEMOKINE; MB21D1 PROTEIN, MOUSE; MEMBRANE PROTEIN; MPYS PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE;

ADAPTIVE IMMUNITY; ADENOVIRUS INFECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN PRESENTING CELL; ANTIVIRAL ACTIVITY; ARTICLE; BONE MARROW DERIVED DENDRITIC CELL; BONE MARROW DERIVED MACROPHAGE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GENE EXPRESSION; HUMAN ADENOVIRUS 5; HUMORAL IMMUNITY; IN VITRO STUDY; INNATE IMMUNITY; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRAL CLEARANCE; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; DENDRITIC CELL; GENE VECTOR; GENETICS; HUMAN; HUMAN ADENOVIRUS C; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; SECRETION (PROCESS); SIGNAL TRANSDUCTION; VIROLOGY; VIRUS REPLICATION;

ADAPTIVE IMMUNITY; ADENOVIRIDAE INFECTIONS; ADENOVIRUSES, HUMAN; ANIMALS; ANTIBODIES, NEUTRALIZING; CHEMOKINES; DENDRITIC CELLS; DNA, VIRAL; GENETIC VECTORS; HEPATOCYTES; HUMANS; IMMUNITY, INNATE; INTERFERON-BETA; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEOTIDYLTRANSFERASES; SIGNAL TRANSDUCTION; VIRUS REPLICATION;

EID: 84975229736     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00500-16     Document Type: Article

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