Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

Journal of Immunology

Volumn 190, Issue 5, 2013, Pages 2311-2319

  Horan, Kristy A ^a   Hansen, Kathrine ^a   Jakobsen, Martin R ^a   Holm, Christian K ^a   Søby, Stine ^b   Unterholzner, Leonie ^c   Thompson, Mikayla ^d   West, John A ^e   Iversen, Marie B ^a   Rasmussen, Simon B ^a   Ellermann Eriksen, Svend ^b   Kurt Jones, Evelyn ^d   Landolfo, Santo ^f   Damania, Blossom ^e   Melchjorsen, Jesper ^b   Bowie, Andrew G ^c   Fitzgerald, Katherine A ^d   Paludan, Søren R ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c TRINITY COLLEGE DUBLIN   (Ireland)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 16; GENOMIC DNA; PROTEASOME; UNCLASSIFIED DRUG; VIRUS DNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOPLASM; CYTOSOL; DNA DETERMINATION; DNA SENSOR; ENZYME DEGRADATION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MOLECULAR SENSOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INDUCTION; UBIQUITINATION; VIRUS CAPSID; VIRUS CELL INTERACTION; VIRUS ENTRY;

ANIMALS; CAPSID; CELL LINE; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; CYTOMEGALOVIRUS; CYTOSOL; DENDRITIC CELLS; DNA, VIRAL; GENE SILENCING; HERPESVIRUS 1, HUMAN; HUMANS; INTERFERON-BETA; MACROPHAGES; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; RNA, SMALL INTERFERING; UBIQUITINATION; VERO CELLS;

EID: 84874246480     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202749     Document Type: Article

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