Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 3, 2016, Pages 596-601

  Devarkar, Swapnil C ^a   Wang, Chen ^b   Miller, Matthew T ^b   Ramanathan, Anand ^a   Jiang, Fuguo ^b   Khan, Abdul G ^b   Patel, Smita S ^a   Marcotrigiano, Joseph ^b  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Capped RNA; Crystal structure; Innate immunity; RIG I; Self versus nonself

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CAPPED RNA; HELICASE; RETINOIC ACID INDUCIBLE PROTEIN I; 7-METHYLGUANOSINE; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; DOUBLE STRANDED RNA; GUANOSINE; RNA; RNA HELICASE;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; IMMUNE EVASION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; RNA BINDING; RNA METHYLATION; RNA STRUCTURE; ANALOGS AND DERIVATIVES; CHEMISTRY; CONFORMATION; HEK293 CELL LINE; HUMAN; HYDROLYSIS; METABOLISM; METHYLATION; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; GUANOSINE; HEK293 CELLS; HUMANS; HYDROLYSIS; IMMUNITY, INNATE; METHYLATION; NUCLEIC ACID CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RNA; RNA CAPS; RNA HELICASES; RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION;

EID: 84955260823     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1515152113     Document Type: Article

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