Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling

Science

Volumn 339, Issue 6120, 2013, Pages 690-693

  Motz, Carina ^a   Schuhmann, Kerstin Monika ^a   Kirchhofer, Axel ^a,c   Moldt, Manuela ^a   Witte, Gregor ^a   Conzelmann, Karl Klaus ^a   Hopfner, Karl Peter ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b Munich Center for Integrated Protein Science   (Germany)

^c Business Consulting Bayer Business Services GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID; HELICASE; MELANOMA DIFFERENTIATION ASSOCIATED PROTEIN 5; PARAMYXOVIRUS V PROTEIN; RETINOIC ACID INDUCIBLE PROTEIN I; RNA; STAT PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID; BIOCHEMISTRY; CHEMICAL BINDING; CRYSTAL STRUCTURE; CYTOPLASM; GENE EXPRESSION; HYDROLYSIS; IMMUNE RESPONSE; IMMUNITY; INHIBITOR; MUTATION; PROTEIN; RNA; SIGNALING; VIRUS;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; PROTEIN STRUCTURE; PROTEIN UNFOLDING; SIGNAL TRANSDUCTION;

PARAMYXOVIRIDAE;

EID: 84873523444     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1230949     Document Type: Article

References (33)

1. Y. M. Loo, M. Gale Jr., Immunity 34, 680 (2011).
2. M. Yoneyama et al., Nat. Immunol. 5, 730 (2004).
3. H. Kato, K. Takahasi, T. Fujita, Immunol. Rev. 243, 91 (2011).
4. H. Kato et al., Nature 441, 101 (2006).
5. S. Rothenfusser et al., J. Immunol. 175, 5260 (2005).
6. T. Satoh et al., Proc. Natl. Acad. Sci. U.S.A. 107, 1512 (2010).
7. V. Hornung et al., Science 314, 994 (2006).
8. A. Pichlmair et al., Science 314, 997 (2006).
9. A. Pichlmair et al., J. Virol. 83, 10761 (2009).
10. K. Malathi, B. Dong, M. Gale Jr., R. H. Silverman, Nature 448, 816 (2007).
11. C. Lu et al., Structure 18, 1032 (2010).
12. Y. Wang et al., Nat. Struct. Mol. Biol. 17, 781 (2010).
13. E. Kowalinski et al., Cell 147, 423 (2011).
14. D. Luo et al., Cell 147, 409 (2011).
15. F. Jiang et al., Nature 479, 423 (2011).
16. M. U. Gack et al., Nature 446, 916 (2007).
17. F. Hou et al., Cell 146, 448 (2011).
18. X. Jiang et al., Immunity 36, 959 (2012).
19. A. G. Bowie, L. Unterholzner, Nat. Rev. Immunol. 8, 911 (2008).
20. J. Andrejeva et al., Proc. Natl. Acad. Sci. U.S.A. 101, 17264 (2004).
21. J. P. Parisien et al., J. Virol. 83, 7252 (2009).
22. K. Childs et al., Virology 359, 190 (2007).
23. K. S. Childs, J. Andrejeva, R. E. Randall, S. Goodbourn, J. Virol. 83, 1465 (2009).
24. A. Ramachandran, C. M. Horvath, J. Virol. 84, 11152 (2010).
25. F. Civril et al., EMBO Rep. 12, 1127 (2011).
26. K. Childs, R. Randall, S. Goodbourn, J. Virol. 86, 3411 (2012).
27. A. Schaap-Nutt et al., J. Virol. 85, 4007 (2011).
28. J. Andrejeva, E. Poole, D. F. Young, S. Goodbourn, R. E. Randall, J. Virol. 76, 11379 (2002).
29. T. Li, X. Chen, K. C. Garbutt, P. Zhou, N. Zheng, Cell 124, 105 (2006).
30. D. Karlin, S. Longhi, V. Receveur, B. Canard, Virology 296, 251 (2002).
31. A. Peisley et al., Proc. Natl. Acad. Sci. U.S.A. 108, 21010 (2011).
32. I. C. Berke, Y. Modis, EMBO J. 31, 1714 (2012).
33. I. C. Berke, X. Yu, Y. Modis, E. H. Egelman, Proc. Natl. Acad. Sci. U.S.A. 109, 18437 (2012).