In Vivo RNAi Screening Identifies MDA5 as a Significant Contributor to the Cellular Defense against Influenza A Virus

Cell Reports

Volumn 11, Issue 11, 2015, Pages 1714-1726

  Benitez, Asiel A ^a   Panis, Maryline ^a   Xue, Jia ^b   Varble, Andrew ^a   Shim, Jaehee V ^a   Frick, Amy L ^a   López, Carolina B ^b   Sachs, David ^a   tenOever, Benjamin R ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; PATTERN RECOGNITION RECEPTOR; DEAD BOX PROTEIN; IFIH1 PROTEIN, HUMAN; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; RARRES3 PROTEIN, HUMAN; RETINOIC ACID RECEPTOR; VIRAL PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; GENE; GENE FUNCTION; GENE LIBRARY; HOST RESISTANCE; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLUENZA A; INFLUENZA VIRUS A; MDA5 GENE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA INTERFERENCE; VIRION; VIRUS ACTIVATION; VIRUS DETECTION; VIRUS REPLICATION; VIRUS STRAIN; WILD TYPE; ANIMAL; GENETICS; HOST PATHOGEN INTERACTION; INFLUENZA A VIRUS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

INFLUENZA A VIRUS; MUS;

ANIMALS; CELL LINE, TUMOR; DEAD-BOX RNA HELICASES; HOST-PATHOGEN INTERACTIONS; HUMANS; INFLUENZA A VIRUS; INTERFERON-INDUCED HELICASE, IFIH1; MICE; RECEPTORS, RETINOIC ACID; RNA INTERFERENCE; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84937639038     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.05.032     Document Type: Article

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