The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

Progress in Neurobiology

Volumn 135, Issue , 2015, Pages 1-20

  Saftig, Paul ^a   Lichtenthaler, Stefan F ^b,c  

^a UNIVERSITY OF KIEL   (Germany)

^b Germany 3 Munich Cluster for Systems Neurology   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

ADAM; Alzheimer disease; APP; Axon; Cell adhesion; Ectodomain shedding; Neurite outgrowth; Neuronal differentiation; Notch 1; Post synapse; Prion; Protease; Signaling; Synaptogenesis; Therapy

Indexed keywords

ADAM10 ENDOPEPTIDASE; ALPHA SECRETASE; AMYLOID PRECURSOR LIKE PROTEIN 2; AMYLOID PRECURSOR PROTEIN; BRI2 PROTEIN; GAMMA PROTOCADHERIN C3; KLOTHO PROTEIN; L1 PROTEIN; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MEMBRANE PROTEIN; MEPRIN; MEPRIN BETA; MESSENGER RNA; NECTIN 1; NEURON GLIA ANTIGEN 2; UNCLASSIFIED DRUG; SECRETASE;

ALZHEIMER DISEASE; BRAIN DEVELOPMENT; BRAIN DISEASE; BRAIN FUNCTION; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASE; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE EXPRESSION; GENE LOCUS; HUMAN; MEMBRANE TRANSPORT; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; REVIEW; TRANSCRIPTION REGULATION; ANIMAL; BRAIN; ENZYMOLOGY; METABOLISM;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; HUMANS;

EID: 84947484060     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2015.10.003     Document Type: Review

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