The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding

Journal of Biological Chemistry

Volumn 290, Issue 12, 2015, Pages 7416-7425

  Maretzky, Thorsten ^a   Evers, Astrid ^a,c   Gall, Sylvain Le ^a,e   Alabi, Rolake O ^a,d   Speck, Nancy ^c   Reiss, Karina ^c   Blobel, Carl P ^a,b  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOLOGICAL MEMBRANES; CHEMICAL ACTIVATION; ENZYME ACTIVITY; SUBSTRATES;

AMYLOID PRECURSOR PROTEINS; CONSTITUTIVELY ACTIVES; CYTOPLASMIC DOMAINS; ECTODOMAIN SHEDDING; EXTRACELLULAR DOMAINS; MEMBRANE PROTEINS; METALLOPROTEINASES; TRANS-MEMBRANE DOMAINS;

PROTEINS;

A DISINTEGRIN AND METALLOPROTEINASE 17 PROTEIN; ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; CALCIUM; L SELECTIN; SERINE PROTEINASE; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG; ADAM10 PROTEIN, MOUSE; MEMBRANE PROTEIN; PRIMER DNA; SECRETASE;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOPLASMIC DOMAIN; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; EXTRACELLULAR DOMAIN; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRANSMEMBRANE DOMAIN; AMINO ACID SEQUENCE; ANIMAL; CELL CULTURE; CHEMISTRY; CYTOPLASM; ENDOPLASMIC RETICULUM; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN DEGRADATION; REAL TIME POLYMERASE CHAIN REACTION;

ADAM PROTEINS; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BASE SEQUENCE; CELLS, CULTURED; CYTOPLASM; DNA PRIMERS; ENDOPLASMIC RETICULUM; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PROTEOLYSIS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84925325088     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.603753     Document Type: Article

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