Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity

Human Molecular Genetics

Volumn 18, Issue 20, 2009, Pages 3987-3996

  Kim, Minji ^a   Suh, Jaehong ^a   Romano, Donna ^a   Truong, Mimy H ^a   Mullin, Kristina ^a   Hooli, Basavaraj ^a   Norton, David ^a   Tesco, Giuseppina ^a   Elliott, Kathy ^b   Wagner, Steven L ^b   Moir, Robert D ^a   Becker, K David ^b   Tanzi, Rudolph E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b TorreyPines Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; ADAM10 PROTEIN; ALPHA SECRETASE; AMYLOID BETA PROTEIN; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; NONHUMAN; ONSET AGE; PENETRANCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; WILD TYPE;

ADAM PROTEINS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MUTATION; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 70349569016     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddp323     Document Type: Article

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