Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions

Journal of Neuroscience

Volumn 33, Issue 32, 2013, Pages 12915-12928

  Prox, Johannes ^a   Bernreuther, Christian ^b   Altmeppen, Hermann ^b   Grende, Jasper ^b   Glatze, Markus ^b   D'Hooge, Rudi ^c   Stroobants, Stijn ^c   Ahmed, Tariq ^c   Balschun, Detlef ^c   Willem, Michael ^d   Lammich, Sven ^d   Isbrandt, Dirk ^b   Schweizer, Michaela ^b   Horré, Katrien ^e,f   De Strooper, Bart ^e,f   Saftig, Paul ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY OF MUNICH   (Germany)

^e DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^f UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM10 ENDOPEPTIDASE; ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; KI 67 ANTIGEN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NECTIN 1; NERVE CELL ADHESION MOLECULE; NEUROLIGIN 1; NOTCH1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CELL ADHESION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPLORATORY BEHAVIOR; FEMALE; HIPPOCAMPAL CA1 REGION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LEARNING DISORDER; LONG TERM POTENTIATION; MALE; MEMORY; MICROGLIA; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEIZURE; SPINE DISEASE; SYNAPTIC POTENTIAL; SYNAPTIC TRANSMISSION; ULTRASTRUCTURE; WEANING; WEIGHT REDUCTION; WESTERN BLOTTING;

ADAM PROTEINS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANIMALS, NEWBORN; BRAIN; CADHERINS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL ADHESION MOLECULES; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; EPILEPSY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLIOSIS; LEARNING DISORDERS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES;

EID: 84881156553     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5910-12.2013     Document Type: Article

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