σ-Secretase processing of APP inhibits neuronal activity in the hippocampus

Nature

Volumn 526, Issue 7573, 2015, Pages 443-447

  Willem, Michael ^a   Tahirovic, Sabina ^b   Busche, Marc Aurel ^c,d   Ovsepian, Saak V ^b   Chafai, Magda ^e   Kootar, Scherazad ^e   Hornburg, Daniel ^f   Evans, Lewis D B ^g   Moore, Steven ^g   Daria, Anna ^a   Hampel, Heike ^a   Müller, Veronika ^a   Giudici, Camilla ^a   Nuscher, Brigitte ^a   Wenninger Weinzierl, Andrea ^b   Kremmer, Elisabeth ^b,d,h   Heneka, Michael T ^b,i   Thal, Dietmar R ^j   Giedraitis, Vilmantas ^k   Lannfelt, Lars ^k   Müller, Ulrike ^l   Livesey, Frederick J ^g   Meissner, Felix ^f   Herms, Jochen ^b   Konnerth, Arthur ^c,d   Marie, Hélène ^e   Haass, Christian ^a,b,d   more..

^a UNIVERSITY OF MUNICH   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d Germany 3 Munich Cluster for Systems Neurology   (Germany)

^e INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^f MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^h INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁱ UNIVERSITY OF BONN   (Germany)

^j UNIVERSITY OF ULM   (Germany)

^k UPPSALA UNIVERSITY   (Sweden)

^l UNIVERSITY OF HEIDELBERG   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADAM10 ENDOPEPTIDASE; ALPHA SECRETASE; AMINO ACID; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SECRETASE 1; ETA SECRETASE; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; APP PROTEIN, HUMAN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; MATRIX METALLOPROTEINASE; MEMBRANE PROTEIN; MMP24 PROTEIN, MOUSE; PEPTIDE FRAGMENT; SECRETASE;

AMINO ACID; BRAIN; DISABILITY; ENZYME ACTIVITY; GENETIC ANALYSIS; METABOLISM; NEUROLOGY; PHYSIOLOGICAL RESPONSE; PROTEIN; RODENT; STOICHIOMETRY;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN ELECTROPHYSIOLOGY; CARBOXY TERMINAL SEQUENCE; CEREBROSPINAL FLUID; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVITY; EX VIVO STUDY; FEMALE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL SLICE; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LONG TERM POTENTIATION; MALE; MOLECULAR WEIGHT; MOUSE; NERVE CELL; NERVE CELL PLASTICITY; NEURITE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN PROCESSING; RAT; STIMULUS RESPONSE; STRATUM RADIATUM; AMYLOID PLAQUE; ANIMAL; ANTAGONISTS AND INHIBITORS; CALCIUM SIGNALING; CHEMISTRY; CYTOLOGY; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; SINGLE CELL ANALYSIS;

MUS;

ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CALCIUM SIGNALING; DISEASE MODELS, ANIMAL; FEMALE; HIPPOCAMPUS; HUMANS; IN VITRO TECHNIQUES; LONG-TERM POTENTIATION; MALE; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; MEMBRANE PROTEINS; MICE; MOLECULAR WEIGHT; NEURITES; NEURONS; PEPTIDE FRAGMENTS; PLAQUE, AMYLOID; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; SINGLE-CELL ANALYSIS;

EID: 84944324335     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14864     Document Type: Article

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