MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease

Cellular and Molecular Life Sciences

Volumn 73, Issue 1, 2016, Pages 217-236

  Baranger, Kévin ^a   Marchalant, Yannick ^a,h   Bonnet, Amandine E ^a   Crouzin, Nadine ^a   Carrete, Alex ^a   Paumier, Jean Michel ^a   Py, Nathalie A ^a   Bernard, Anne ^a   Bauer, Charlotte ^b   Charrat, Eliane ^a   Moschke, Katrin ^c,d   Seiki, Mothoharu ^e   Vignes, Michel ^f   Lichtenthaler, Stefan F ^c,d,g   Checler, Frédéric ^b   Khrestchatisky, Michel ^a   Rivera, Santiago ^a  

^a Mediterranée University   (France)

^b INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITY OF TOKYO   (Japan)

^f UNIV MONTPELLIER   (France)

^g Germany 3 Munich Cluster for Systems Neurology   (Germany)

^h CENTRAL MICHIGAN UNIVERSITY   (United States)

Author keywords

Knockout mouse; MMP 24; Neurodegenerative disease; Neuroprotection; Synaptotoxicity

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN C TERMINAL FRAGMENT 99; BETA SECRETASE; GAMMA SECRETASE; GELATINASE A; GELATINASE B; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 1BETA; MATRIX METALLOPROTEINASE; MEMBRANE TYPE 5 MATRIX METALLOPROTEINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; MMP24 PROTEIN, MOUSE; SECRETASE;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; AMYLOIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APP GENE; ARTICLE; ASTROCYTE; CELLULAR DISTRIBUTION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME ACTIVITY; ENZYME DEFICIENCY; GENETIC ENGINEERING; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LONG TERM POTENTIATION; MALE; MICROGLIA; MOLECULAR DYNAMICS; MOUSE; NEOCORTEX; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; SOMATOSENSORY MOTOR CORTEX; SPATIAL LEARNING; TRANSGENIC MOUSE; VISUAL CORTEX; ANIMAL; C57BL MOUSE; COGNITION; ENZYMOLOGY; FEMALE; GENE DELETION; GENETICS; HEK293 CELL LINE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; COGNITION; FEMALE; GENE DELETION; HEK293 CELLS; HIPPOCAMPUS; HUMANS; LONG-TERM POTENTIATION; MALE; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; MICE, INBRED C57BL; MICE, TRANSGENIC; SPATIAL LEARNING;

EID: 84952985156     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-1992-1     Document Type: Article

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