Unidirectional Notch signaling depends on continuous cleavage of Delta

Development

Volumn 132, Issue 1, 2005, Pages 123-132

  Sapir, Amir ^a   Assa Kunik, Efrat ^a   Tsruya, Rachel ^a   Schejter, Eyal ^a   Shilo, Ben Zion ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

ADAM metalloproteases; Delta; Drosophila; Kuzbanian like; Notch; Serrate; Wing development

Indexed keywords

DROSOPHILA PROTEIN; KUZBANIAN ADAM METALLOPROTEINASE; METALLOPROTEINASE; NOTCH RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL STRUCTURE; CONTROLLED STUDY; DROSOPHILA; FLY; FORELIMB; LIMB DEVELOPMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; SIGNAL PROCESSING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELLS, CULTURED; DISINTEGRINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IN SITU HYBRIDIZATION; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; METALLOPROTEASES; PHENOTYPE; PHYLOGENY; PROTEIN BINDING; RECEPTORS, NOTCH; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; WING;

EID: 13444283768     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01546     Document Type: Article

References (43)

1. Artavanis-Tsakonas, S., Rand, M. D. and Lake, R. J. (1999). Notch signaling: cell fate control and signal integration in development. Science 284, 770-776.
2. Axelrod, J. D. (2001). Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. Genes Dev. 15, 1182-1187.
3. Baron, M. (2003). An overview of the Notch signalling pathway. Semin. Cell Dev. Biol. 14, 113-119.
4. Berdnik, D., Torok, T., Gonzalez-Gaitan, M. and Knoblich, J. A. (2002). The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev. Cell 3, 221-231.
5. Bruckner, K., Perez, L., Clausen, H. and Cohen, S. (2000). Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature 406, 411-415.
6. Cao, Y., Kang, Q., Zhao, Z. and Zolkiewska, A. (2002). Intracellular processing of metalloprotease disintegrin ADAM12. J. Biol. Chem. 277, 26403-26411.
7. Chase, B. A., Holliday, J., Reese, J. H., Chun, L. L. and Hawrot, E. (1987). Monoclonal antibodies with defined specificities for Torpedo nicotinic acetylcholine receptor cross-react with Drosophila neural tissue. Neuroscience 21, 959-976.
8. Chen, N. and Greenwald, I. (2004). The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. Dev. Cell 6, 183-192.
9. de Celis, J. F. (2003). Pattern formation in the Drosophila wing: the development of the veins. BioEssays 25, 443-451.
10. de Celis, J. F. and Bray, S. (1997). Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing. Development 124, 3241-3251.
11. de Celis, J. F., Bray, S. and Garcia-Bellido, A. (1997). Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing. Development 124, 1919-1928.
12. De Joussineau, C., Soule, J., Martin, M., Anguille, C., Montcourrier, P. and Alexandre, D. (2003). Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila. Nature 426 555-559.
13. Fleming, R. J., Gu, Y. and Hukriede, N. A. (1997). Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development 124, 2973-2981.
14. Frise, E., Knoblich, J. A., Younger-Shepherd, S., Jan, L. Y. and Jan, Y. N. (1996). The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc. Natl. Acad. Sci. USA 93, 11925-11932.
15. Furriols, M. and Bray, S. (2001). A model Notch response element detects Suppressor of Hairless-dependent molecular switch. Curr. Biol. 11, 60-64.
16. Hartmann, D., de Strooper, B., Serneels, L., Craessaerts, K., Herreman, A., Annaert, W., Umans, L., Lubke, T., Lena Illert, A., von Figura, K. et al. (2002). The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum. Mol. Genet. 11, 2615-2624.
17. Hattori, M., Osterfield, M. and Flanagan, J. G. (2000). Regulated cleavage of a contact-mediated axon repellent. Science 289, 1360-1365.
18. Heitzler, P., Bourouis, M., Ruel, L., Carteret, C. and Simpson, P. (1996). Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development 122, 161-171.
19. Hinz, U., Giebel, B. and Campos-Ortega, J. A. (1994). The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 76, 77-87.
20. Huppert, S. S., Jacobsen, T. L. and Muskavitch, M. A. (1997). Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis. Development 124, 3283-3291.
21. Kooh, P. J., Fehon, R. G. and Muskavitch, M. A. (1993). Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development. Development 117, 493-507.
22. Kunisch, M., Haenlin, M. and Campos-Ortega, J. A. (1994). Lateral inhibition mediated by the Drosophila neurogenic gene delta is enhanced by proneural proteins. Proc. Natl. Acad. Sci. USA 91, 10139-10143.
23. Lai, E. C. (2004). Notch signaling: control of cell communication and cell fate. Development 131, 965-973.
24. Le Borgne, R. and Schweisguth, F. (2003). Unequal segregation of Neuralized biases Notch activation during asymmetric cell division. Dev. Cell 5, 139-148.
25. Lieber, T., Kidd, S. and Young, M. W. (2002). kuzbanian-mediated cleavage of Drosophila Notch. Genes Dev. 16 209-221.
26. Micchelli, C. A., Rulifson, E. J. and Blair, S. S. (1997). The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 124, 1485-1495.
27. Mishra-Gorur, K., Rand, M. D., Perez-Villamil, B. and Artavanis-Tsakonas, S. (2002). Down-regulation of Delta by proteolytic processing. J. Cell Biol. 159, 313-324.
28. Mumm, J. S. and Kopan, R. (2000). Notch signaling: from the outside in. Dev. Biol. 228, 151-165.
29. Mumm, J. S., Schroeter, E. H., Saxena, M. T., Griesemer, A., Tian, X., Pan, D. J., Ray, W. J. and Kopan, R. (2000). A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol. Cell 5, 197-206.
30. Neumann, C. J. and Cohen, S. M. (1996). A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing. Development 122 3477-3485.
31. Okajima, T. and Irvine, K. D. (2002). Regulation of notch signaling by o-linked fucose. Cell 111, 893-904.
32. Pan, D. and Rubin, G. M. (1997). Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 90, 271-280.
33. Panin, V. M., Papayannopoulos, V., Wilson, R. and Irvine, K. D. (1997). Fringe modulates Notch-ligand interactions. Nature 387, 908-912.
34. Parks, A. L., Klueg, K. M., Stout, J. R. and Muskavitch, M. A. (2000). Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development 127, 1373-1385.
35. Primakoff, P. and Myles, D. G. (2000). The ADAM gene family: surface proteins with adhesion and protease activity. Trends Genet. 16, 83-87.
36. Qi, H., Rand, M. D., Wu, X., Sestan, N., Wang, W., Rakic, P., Xu, T. and Artavanis-Tsakonas, S. (1999). Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science 283, 91-94.
37. Schweisguth, F. (2004). Notch signaling activity. Curr. Biol. 14, R129-R138.
38. Shaye, D. D. and Greenwald, I. (2002). Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans. Nature 420, 686-690.
39. Six, E., Ndiaye, D., Laabi, Y., Brou, C., Gupta-Rossi, N., Israel, A. and Logeat, F. (2003). The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase. Proc. Natl. Acad. Sci. USA 100, 7638-7643.
40. Sotillos, S., Roch, F. and Campuzano, S. (1997). The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Development 124, 4769-4779.
41. Struhl, G. and Adachi, A. (1998). Nuclear access and action of notch in vivo. Cell 93, 649-660.
42. Tomlinson, A. and Ready, D. F. (1987). Neuronal differentiation in the Drosophila Ommatidium. Dev. Biol. 120, 366-376.
43. Tsruya, R., Schlesinger, A., Reich, A., Gabay, L., Sapir, A. and Shilo, B. Z. (2002). Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz. Genes Dev. 16, 222-234.