The functional maturation of a disintegrin and metalloproteinase (ADAM) 9, 10, and 17 requires processing at a newly identified proprotein convertase (PC) cleavage site

Journal of Biological Chemistry

Volumn 290, Issue 19, 2015, Pages 12135-12146

  Wong, Eitan ^a   Maretzky, Thorsten ^b   Peleg, Yoav ^a   Blobel, Carl P ^b,c   Sagi, Irit ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; ENZYME ACTIVITY;

CATALYTIC DOMAINS; CLEAVAGE SITES; DOMAIN PROCESSING; METALLO-PROTEASE; METALLOPROTEASES; METALLOPROTEINASES; PROPROTEIN CONVERTASE FURIN; PROTEOLYTIC PROCESSING;

CATALYST ACTIVITY;

ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; ADAM17 PROTEIN; ADAM9 PROTEIN; FURIN; MUTANT PROTEIN; PROPROTEIN CONVERTASE; SERINE PROTEINASE; UNCLASSIFIED DRUG; ADAM10 PROTEIN, MOUSE; ADAM9 PROTEIN, MOUSE; MEMBRANE PROTEIN; RECOMBINANT PROTEIN; SECRETASE; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REGULATORY SEQUENCE; SEQUENCE ALIGNMENT; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; CELL MEMBRANE; CHEMISTRY; CIRCULAR DICHROISM; ESCHERICHIA COLI; FIBROBLAST; GENETICS; HEK293 CELL LINE; HUMAN; KNOCKOUT MOUSE; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MUTATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

ADAM PROTEINS; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL MEMBRANE; CIRCULAR DICHROISM; CLONING, MOLECULAR; ESCHERICHIA COLI; FIBROBLASTS; FURIN; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84929093820     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.624072     Document Type: Article

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