Metalloprotease ADAM10 is required for Notch1 site 2 cleavage

Journal of Biological Chemistry

Volumn 284, Issue 45, 2009, Pages 31018-31027

  van Tetering, Geert ^a   van Diest, Paul ^a   Verlaan, Ingrid ^a   van der Wall, Elsken ^a   Kopan, Raphael ^b   Vooijs, Marc ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELLS; CONVERTING ENZYME; EXTRACELLULAR; EXTRACELLULAR DOMAINS; GAIN-OF FUNCTION; HUMAN CANCER; IN-CELL; INTRACELLULAR DOMAIN; LIGAND BINDING; METALLO-PROTEASE; METALLOPROTEASES; MODEL ORGANISMS; NECROSIS FACTORS; NEGATIVE CONTROL; NOTCH SIGNALING; PHARMACOLOGICAL INHIBITION; PLASMA MEMBRANES; PROTEOLYTIC CLEAVAGE; RATE LIMITING; SECRETASES; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; BIOCHEMISTRY; CELL MEMBRANES; LIGANDS;

ENZYME ACTIVITY;

ADAM10 ENDOPEPTIDASE; METALLOPROTEINASE; NOTCH1 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

ARTICLE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

ADAM PROTEINS; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE, TUMOR; CELL MEMBRANE; HUMANS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NOTCH1;

EID: 71449113533     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.006775     Document Type: Article

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