5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10

ACS Chemical Neuroscience

Volumn 4, Issue 1, 2013, Pages 130-140

  Cochet, Maud ^a,b   Donneger, Romain ^a,b   Cassier, Elisabeth ^a,b   Gaven, Florence ^a,b   Lichtenthaler, Stefan F ^c   Marin, Philippe ^a,b   Bockaert, Joël ^a,b   Dumuis, Aline ^a,b   Claeysen, Sylvie ^a,b  

^a INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^b UNIV MONTPELLIER   (France)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

Alpha secretase; Alzheimer's disease; sAPP alpha; serotonin

Indexed keywords

ADAM10 ENDOPEPTIDASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; SEROTONIN 4 RECEPTOR; SOLUBLE AND NEUROPROTECTIVE AMYLOID PRECURSOR PROTEIN ALPHA; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; BENZOFURAN DERIVATIVE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; MEMBRANE PROTEIN; NEUROPROTECTIVE AGENT; PRUCALOPRIDE; SECRETASE; SEROTONIN 4 AGONIST;

ARTICLE; BRAIN NERVE CELL; CELL STRAIN HEK293; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SECRETION; ALZHEIMER DISEASE; BRAIN CORTEX; CYTOLOGY; METABOLISM; PHYSIOLOGY;

ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; BENZOFURANS; CEREBRAL CORTEX; CYCLIC AMP; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; NEUROPROTECTIVE AGENTS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN 5-HT4 RECEPTOR AGONISTS;

MLCS; MLOWN;

EID: 84872536346     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn300095t     Document Type: Article

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