Metalloprotease meprin β generates nontoxic N-terminal amyloid precursor protein fragments in vivo

Journal of Biological Chemistry

Volumn 286, Issue 31, 2011, Pages 27741-27750

  Jefferson, Tamara ^a   Čaušević, Mirsada ^a   Auf Dem Keller, Ulrich ^b   Schilling, Oliver ^c   Isbert, Simone ^a   Geyer, Rebecca ^a   Maier, Wladislaw ^a   Tschickardt, Sabrina ^a   Jumpertz, Thorsten ^d   Weggen, Sascha ^d   Bond, Judith S ^e   Overall, Christopher M ^f   Pietrzik, Claus U ^a   Becker Pauly, Christoph ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF FREIBURG   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e PENN STATE COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; CELL SURFACE PROTEINS; IN-VITRO; IN-VIVO; ISOTOPIC LABELING; LYSATES; METALLO-PROTEASE; MOUSE BRAIN; N-TERMINALS; NEURODEGENERATION; PROTEOMICS;

CELL MEMBRANES; ENZYMES; GLYCOPROTEINS; MAMMALS; MOLECULAR BIOLOGY; PHYSIOLOGY; SUBSTRATES; TISSUE;

PROTEINS;

AMYLOID PRECURSOR PROTEIN; MEPRIN; MEPRIN BETA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN TISSUE; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; KERATINOCYTE; MOLECULAR WEIGHT; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEOMICS; RAT;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BASE SEQUENCE; BRAIN; CELL LINE; DNA PRIMERS; HUMANS; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TIOPRONIN;

EID: 79961012890     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.252718     Document Type: Article

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