메뉴 건너뛰기




Volumn 110, Issue 45, 2013, Pages 18303-18308

Neuroprotective Sirtuin ratio reversed by ApoE4

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN ALPHA; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; PROTEIN PRECURSOR; RECOMBINANT PROTEIN; RECOMBINANT SIRTUIN; SIRTUIN 1; SIRTUIN 2; TAU PROTEIN; UNCLASSIFIED DRUG;

EID: 84887314994     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1314145110     Document Type: Article
Times cited : (86)

References (29)
  • 1
    • 84878699428 scopus 로고    scopus 로고
    • Next generation therapeutics for Alzheimer's disease
    • Bredesen DE, John V (2013) Next generation therapeutics for Alzheimer's disease. EMBO Mol Med 5(6):795-798.
    • (2013) EMBO Mol Med , vol.5 , Issue.6 , pp. 795-798
    • Bredesen, D.E.1    John, V.2
  • 2
    • 33645808672 scopus 로고    scopus 로고
    • Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease
    • Mahley RW, Weisgraber KH, Huang Y (2006) Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Natl Acad Sci USA 103(15):5644-5651.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.15 , pp. 5644-5651
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 3
    • 0141814636 scopus 로고    scopus 로고
    • Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice
    • Harris FM, et al. (2003) Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc Natl Acad Sci USA 100(19):10966-10971.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.19 , pp. 10966-10971
    • Harris, F.M.1
  • 4
    • 29444460533 scopus 로고    scopus 로고
    • Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target
    • Ye S, et al. (2005) Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target. Proc Natl Acad Sci USA 102(51):18700-18705.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.51 , pp. 18700-18705
    • Ye, S.1
  • 5
    • 84877326649 scopus 로고    scopus 로고
    • ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions
    • Verghese PB, et al. (2013) ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions. Proc Natl Acad Sci USA 110(19):E1807-E1816.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.19
    • Verghese, P.B.1
  • 6
    • 67749139805 scopus 로고    scopus 로고
    • Neurodegeneration in Alzheimer's disease: Caspases and synaptic element interdependence
    • Bredesen DE (2009) Neurodegeneration in Alzheimer's disease: Caspases and synaptic element interdependence. Mol Neurodegener 4:27.
    • (2009) Mol Neurodegener , vol.4 , pp. 27
    • Bredesen, D.E.1
  • 7
    • 0041886881 scopus 로고    scopus 로고
    • Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients
    • Olsson A, et al. (2003) Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients. Exp Neurol 183(1):74-80.
    • (2003) Exp Neurol , vol.183 , Issue.1 , pp. 74-80
    • Olsson, A.1
  • 8
    • 84878617717 scopus 로고    scopus 로고
    • Sirtuins as possible targets in neurodegenerative diseases
    • Donmez G (2013) Sirtuins as possible targets in neurodegenerative diseases. Curr Drug Targets 14(6):644-647.
    • (2013) Curr Drug Targets , vol.14 , Issue.6 , pp. 644-647
    • Donmez, G.1
  • 9
    • 66349085616 scopus 로고    scopus 로고
    • Apolipoprotein E: Structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
    • Mahley RW, Weisgraber KH, Huang Y (2009) Apolipoprotein E: Structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res 50(Suppl):S183-S188.
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 10
    • 84863111022 scopus 로고    scopus 로고
    • Altering APP proteolysis: Increasing sAPPalpha production by targeting dimerization of the APP ectodomain
    • Libeu CA, Descamps O, Zhang Q, John V, Bredesen DE (2012) Altering APP proteolysis: Increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS ONE 7(6):e40027.
    • (2012) PLoS ONE , vol.7 , Issue.6
    • Libeu, C.A.1    Descamps, O.2    Zhang, Q.3    John, V.4    Bredesen, D.E.5
  • 11
    • 0030797917 scopus 로고    scopus 로고
    • Apolipoprotein E forms stable complexes with recombinant Alzheimer's disease beta-amyloid precursor protein
    • Haas C, Cazorla P, Miguel CD, Valdivieso F, Vázquez J (1997) Apolipoprotein E forms stable complexes with recombinant Alzheimer's disease beta-amyloid precursor protein. Biochem J 325(Pt 1):169-175.
    • (1997) Biochem J , vol.325 , Issue.PART 1 , pp. 169-175
    • Haas, C.1    Cazorla, P.2    Miguel, C.D.3    Valdivieso, F.4    Vázquez, J.5
  • 12
    • 33746824192 scopus 로고    scopus 로고
    • Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    • Qin W, et al. (2006) Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem 281(31):21745-21754.
    • (2006) J Biol Chem , vol.281 , Issue.31 , pp. 21745-21754
    • Qin, W.1
  • 13
    • 64049092736 scopus 로고    scopus 로고
    • Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease
    • Julien C, et al. (2009) Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J Neuropathol Exp Neurol 68(1):48-58.
    • (2009) J Neuropathol Exp Neurol , vol.68 , Issue.1 , pp. 48-58
    • Julien, C.1
  • 14
    • 0142123260 scopus 로고    scopus 로고
    • APP processing is regulated by cytoplasmic phosphorylation
    • Lee MS, et al. (2003) APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol 163(1):83-95.
    • (2003) J Cell Biol , vol.163 , Issue.1 , pp. 83-95
    • Lee, M.S.1
  • 15
    • 0037966577 scopus 로고    scopus 로고
    • Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5
    • Liu F, et al. (2003) Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5. FEBS Lett 547(1-3):193-196.
    • (2003) FEBS Lett , vol.547 , Issue.1-3 , pp. 193-196
    • Liu, F.1
  • 16
    • 34047181415 scopus 로고    scopus 로고
    • Abeta, tau and ApoE4 in Alzheimer's disease: The axonal connection
    • Adalbert R, Gilley J, Coleman MP (2007) Abeta, tau and ApoE4 in Alzheimer's disease: The axonal connection. Trends Mol Med 13(4):135-142.
    • (2007) Trends Mol Med , vol.13 , Issue.4 , pp. 135-142
    • Adalbert, R.1    Gilley, J.2    Coleman, M.P.3
  • 17
    • 77957256216 scopus 로고    scopus 로고
    • Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration
    • Alonso AD, et al. (2010) Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. J Biol Chem 285(40):30851-30860.
    • (2010) J Biol Chem , vol.285 , Issue.40 , pp. 30851-30860
    • Alonso, A.D.1
  • 18
    • 78650662312 scopus 로고    scopus 로고
    • Importance of the caspase cleavage site in amyloid-β protein precursor
    • Bredesen DE, John V, Galvan V (2010) Importance of the caspase cleavage site in amyloid-β protein precursor. J Alzheimers Dis 22(1):57-63.
    • (2010) J Alzheimers Dis , vol.22 , Issue.1 , pp. 57-63
    • Bredesen, D.E.1    John, V.2    Galvan, V.3
  • 19
    • 77949595824 scopus 로고    scopus 로고
    • Upregulation of the alpha-secretase ADAM10-risk or reason for hope?
    • Endres K, Fahrenholz F (2010) Upregulation of the alpha-secretase ADAM10-risk or reason for hope? FEBS J 277(7):1585-1596.
    • (2010) FEBS J , vol.277 , Issue.7 , pp. 1585-1596
    • Endres, K.1    Fahrenholz, F.2
  • 20
    • 0035372336 scopus 로고    scopus 로고
    • Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
    • Cedazo-Mínguez A, Wiehager B, Winblad B, Hüttinger M, Cowburn RF (2001) Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts. Neurochem Int 38(7):615-625.
    • (2001) Neurochem Int , vol.38 , Issue.7 , pp. 615-625
    • Cedazo-Mínguez, A.1    Wiehager, B.2    Winblad, B.3    Hüttinger, M.4    Cowburn, R.F.5
  • 21
    • 0034889517 scopus 로고    scopus 로고
    • Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoformspecific manner
    • Vincent B, Smith JD (2001) Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoformspecific manner. Eur J Neurosci 14(2):256-266.
    • (2001) Eur J Neurosci , vol.14 , Issue.2 , pp. 256-266
    • Vincent, B.1    Smith, J.D.2
  • 22
    • 84873096554 scopus 로고    scopus 로고
    • Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: Neuroprotective or neurotoxic properties of sirtuins in ALS?
    • Korner S, et al. (2013) Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: Neuroprotective or neurotoxic properties of sirtuins in ALS? Neurodegener Dis 11(3):141-152.
    • (2013) Neurodegener Dis , vol.11 , Issue.3 , pp. 141-152
    • Korner, S.1
  • 23
    • 34547599329 scopus 로고    scopus 로고
    • Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
    • Outeiro TF, et al. (2007) Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 317(5837):516-519.
    • (2007) Science , vol.317 , Issue.5837 , pp. 516-519
    • Outeiro, T.F.1
  • 24
    • 84866314843 scopus 로고    scopus 로고
    • MicroRNA regulation of SIRT1
    • Yamakuchi M (2012) MicroRNA Regulation of SIRT1. Front Physiol 3:68.
    • (2012) Front Physiol , vol.3 , pp. 68
    • Yamakuchi, M.1
  • 25
    • 76549115951 scopus 로고    scopus 로고
    • Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition
    • Finch CE (2010) Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition. Proc Natl Acad Sci USA 107(Suppl 1):1718-1724.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.SUPPL. 1 , pp. 1718-1724
    • Finch, C.E.1
  • 26
    • 77957001697 scopus 로고    scopus 로고
    • Acetylation of tau inhibits its degradation and contributes to tauopathy
    • Min SW, et al. (2010) Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67(6):953-966.
    • (2010) Neuron , vol.67 , Issue.6 , pp. 953-966
    • Min, S.W.1
  • 27
    • 33646862834 scopus 로고    scopus 로고
    • Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration
    • Chang KA, et al. (2006) Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration. Mol Cell Biol 26(11):4327-4338.
    • (2006) Mol Cell Biol , vol.26 , Issue.11 , pp. 4327-4338
    • Chang, K.A.1
  • 28
    • 48149090212 scopus 로고    scopus 로고
    • The value of proteasome inhibition in cancer. Can the old drug, disulfiram, have a bright new future as a novel proteasome inhibitor?
    • Cvek B, Dvorak Z (2008) The value of proteasome inhibition in cancer. Can the old drug, disulfiram, have a bright new future as a novel proteasome inhibitor? Drug Discov Today 13(15-16):716-722.
    • (2008) Drug Discov Today , vol.13 , Issue.15-16 , pp. 716-722
    • Cvek, B.1    Dvorak, Z.2
  • 29
    • 40449087334 scopus 로고    scopus 로고
    • Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
    • Wen Y, et al. (2008) Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci 28(10):2624-2632.
    • (2008) J Neurosci , vol.28 , Issue.10 , pp. 2624-2632
    • Wen, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.