-
1
-
-
84878699428
-
Next generation therapeutics for Alzheimer's disease
-
Bredesen DE, John V (2013) Next generation therapeutics for Alzheimer's disease. EMBO Mol Med 5(6):795-798.
-
(2013)
EMBO Mol Med
, vol.5
, Issue.6
, pp. 795-798
-
-
Bredesen, D.E.1
John, V.2
-
2
-
-
33645808672
-
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease
-
Mahley RW, Weisgraber KH, Huang Y (2006) Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc Natl Acad Sci USA 103(15):5644-5651.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.15
, pp. 5644-5651
-
-
Mahley, R.W.1
Weisgraber, K.H.2
Huang, Y.3
-
3
-
-
0141814636
-
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice
-
Harris FM, et al. (2003) Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc Natl Acad Sci USA 100(19):10966-10971.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.19
, pp. 10966-10971
-
-
Harris, F.M.1
-
4
-
-
29444460533
-
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target
-
Ye S, et al. (2005) Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target. Proc Natl Acad Sci USA 102(51):18700-18705.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.51
, pp. 18700-18705
-
-
Ye, S.1
-
5
-
-
84877326649
-
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions
-
Verghese PB, et al. (2013) ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions. Proc Natl Acad Sci USA 110(19):E1807-E1816.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.19
-
-
Verghese, P.B.1
-
6
-
-
67749139805
-
Neurodegeneration in Alzheimer's disease: Caspases and synaptic element interdependence
-
Bredesen DE (2009) Neurodegeneration in Alzheimer's disease: Caspases and synaptic element interdependence. Mol Neurodegener 4:27.
-
(2009)
Mol Neurodegener
, vol.4
, pp. 27
-
-
Bredesen, D.E.1
-
7
-
-
0041886881
-
Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients
-
Olsson A, et al. (2003) Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients. Exp Neurol 183(1):74-80.
-
(2003)
Exp Neurol
, vol.183
, Issue.1
, pp. 74-80
-
-
Olsson, A.1
-
8
-
-
84878617717
-
Sirtuins as possible targets in neurodegenerative diseases
-
Donmez G (2013) Sirtuins as possible targets in neurodegenerative diseases. Curr Drug Targets 14(6):644-647.
-
(2013)
Curr Drug Targets
, vol.14
, Issue.6
, pp. 644-647
-
-
Donmez, G.1
-
9
-
-
66349085616
-
Apolipoprotein E: Structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
-
Mahley RW, Weisgraber KH, Huang Y (2009) Apolipoprotein E: Structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res 50(Suppl):S183-S188.
-
(2009)
J Lipid Res
, vol.50
, Issue.SUPPL.
-
-
Mahley, R.W.1
Weisgraber, K.H.2
Huang, Y.3
-
10
-
-
84863111022
-
Altering APP proteolysis: Increasing sAPPalpha production by targeting dimerization of the APP ectodomain
-
Libeu CA, Descamps O, Zhang Q, John V, Bredesen DE (2012) Altering APP proteolysis: Increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS ONE 7(6):e40027.
-
(2012)
PLoS ONE
, vol.7
, Issue.6
-
-
Libeu, C.A.1
Descamps, O.2
Zhang, Q.3
John, V.4
Bredesen, D.E.5
-
11
-
-
0030797917
-
Apolipoprotein E forms stable complexes with recombinant Alzheimer's disease beta-amyloid precursor protein
-
Haas C, Cazorla P, Miguel CD, Valdivieso F, Vázquez J (1997) Apolipoprotein E forms stable complexes with recombinant Alzheimer's disease beta-amyloid precursor protein. Biochem J 325(Pt 1):169-175.
-
(1997)
Biochem J
, vol.325
, Issue.PART 1
, pp. 169-175
-
-
Haas, C.1
Cazorla, P.2
Miguel, C.D.3
Valdivieso, F.4
Vázquez, J.5
-
12
-
-
33746824192
-
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
-
Qin W, et al. (2006) Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem 281(31):21745-21754.
-
(2006)
J Biol Chem
, vol.281
, Issue.31
, pp. 21745-21754
-
-
Qin, W.1
-
13
-
-
64049092736
-
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease
-
Julien C, et al. (2009) Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J Neuropathol Exp Neurol 68(1):48-58.
-
(2009)
J Neuropathol Exp Neurol
, vol.68
, Issue.1
, pp. 48-58
-
-
Julien, C.1
-
14
-
-
0142123260
-
APP processing is regulated by cytoplasmic phosphorylation
-
Lee MS, et al. (2003) APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol 163(1):83-95.
-
(2003)
J Cell Biol
, vol.163
, Issue.1
, pp. 83-95
-
-
Lee, M.S.1
-
15
-
-
0037966577
-
Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5
-
Liu F, et al. (2003) Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5. FEBS Lett 547(1-3):193-196.
-
(2003)
FEBS Lett
, vol.547
, Issue.1-3
, pp. 193-196
-
-
Liu, F.1
-
16
-
-
34047181415
-
Abeta, tau and ApoE4 in Alzheimer's disease: The axonal connection
-
Adalbert R, Gilley J, Coleman MP (2007) Abeta, tau and ApoE4 in Alzheimer's disease: The axonal connection. Trends Mol Med 13(4):135-142.
-
(2007)
Trends Mol Med
, vol.13
, Issue.4
, pp. 135-142
-
-
Adalbert, R.1
Gilley, J.2
Coleman, M.P.3
-
17
-
-
77957256216
-
Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration
-
Alonso AD, et al. (2010) Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. J Biol Chem 285(40):30851-30860.
-
(2010)
J Biol Chem
, vol.285
, Issue.40
, pp. 30851-30860
-
-
Alonso, A.D.1
-
18
-
-
78650662312
-
Importance of the caspase cleavage site in amyloid-β protein precursor
-
Bredesen DE, John V, Galvan V (2010) Importance of the caspase cleavage site in amyloid-β protein precursor. J Alzheimers Dis 22(1):57-63.
-
(2010)
J Alzheimers Dis
, vol.22
, Issue.1
, pp. 57-63
-
-
Bredesen, D.E.1
John, V.2
Galvan, V.3
-
19
-
-
77949595824
-
Upregulation of the alpha-secretase ADAM10-risk or reason for hope?
-
Endres K, Fahrenholz F (2010) Upregulation of the alpha-secretase ADAM10-risk or reason for hope? FEBS J 277(7):1585-1596.
-
(2010)
FEBS J
, vol.277
, Issue.7
, pp. 1585-1596
-
-
Endres, K.1
Fahrenholz, F.2
-
20
-
-
0035372336
-
Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
-
Cedazo-Mínguez A, Wiehager B, Winblad B, Hüttinger M, Cowburn RF (2001) Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts. Neurochem Int 38(7):615-625.
-
(2001)
Neurochem Int
, vol.38
, Issue.7
, pp. 615-625
-
-
Cedazo-Mínguez, A.1
Wiehager, B.2
Winblad, B.3
Hüttinger, M.4
Cowburn, R.F.5
-
21
-
-
0034889517
-
Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoformspecific manner
-
Vincent B, Smith JD (2001) Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoformspecific manner. Eur J Neurosci 14(2):256-266.
-
(2001)
Eur J Neurosci
, vol.14
, Issue.2
, pp. 256-266
-
-
Vincent, B.1
Smith, J.D.2
-
22
-
-
84873096554
-
Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: Neuroprotective or neurotoxic properties of sirtuins in ALS?
-
Korner S, et al. (2013) Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: Neuroprotective or neurotoxic properties of sirtuins in ALS? Neurodegener Dis 11(3):141-152.
-
(2013)
Neurodegener Dis
, vol.11
, Issue.3
, pp. 141-152
-
-
Korner, S.1
-
23
-
-
34547599329
-
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
-
Outeiro TF, et al. (2007) Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 317(5837):516-519.
-
(2007)
Science
, vol.317
, Issue.5837
, pp. 516-519
-
-
Outeiro, T.F.1
-
24
-
-
84866314843
-
MicroRNA regulation of SIRT1
-
Yamakuchi M (2012) MicroRNA Regulation of SIRT1. Front Physiol 3:68.
-
(2012)
Front Physiol
, vol.3
, pp. 68
-
-
Yamakuchi, M.1
-
25
-
-
76549115951
-
Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition
-
Finch CE (2010) Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: Roles of infection, inflammation, and nutrition. Proc Natl Acad Sci USA 107(Suppl 1):1718-1724.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.SUPPL. 1
, pp. 1718-1724
-
-
Finch, C.E.1
-
26
-
-
77957001697
-
Acetylation of tau inhibits its degradation and contributes to tauopathy
-
Min SW, et al. (2010) Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67(6):953-966.
-
(2010)
Neuron
, vol.67
, Issue.6
, pp. 953-966
-
-
Min, S.W.1
-
27
-
-
33646862834
-
Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration
-
Chang KA, et al. (2006) Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration. Mol Cell Biol 26(11):4327-4338.
-
(2006)
Mol Cell Biol
, vol.26
, Issue.11
, pp. 4327-4338
-
-
Chang, K.A.1
-
28
-
-
48149090212
-
The value of proteasome inhibition in cancer. Can the old drug, disulfiram, have a bright new future as a novel proteasome inhibitor?
-
Cvek B, Dvorak Z (2008) The value of proteasome inhibition in cancer. Can the old drug, disulfiram, have a bright new future as a novel proteasome inhibitor? Drug Discov Today 13(15-16):716-722.
-
(2008)
Drug Discov Today
, vol.13
, Issue.15-16
, pp. 716-722
-
-
Cvek, B.1
Dvorak, Z.2
-
29
-
-
40449087334
-
Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
-
Wen Y, et al. (2008) Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci 28(10):2624-2632.
-
(2008)
J Neurosci
, vol.28
, Issue.10
, pp. 2624-2632
-
-
Wen, Y.1
|