Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration

FEBS Journal

Volumn 280, Issue 18, 2013, Pages 4338-4347

  Altmeppen, Hermann C ^a   Prox, Johannes ^b   Puig, Berta ^a   Dohler, Frank ^a   Falker, Clemens ^a   Krasemann, Susanne ^a   Glatzel, Markus ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

cleavage; amyloid; ADAM10; Alzheimer's disease; neurodegeneration; neurotoxic oligomers; prion disease; prion protein; shedding

Indexed keywords

ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; ADAM17 PROTEIN; ADAM8 PROTEIN; AMYLOID PRECURSOR PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTOXIN; NOTCH RECEPTOR; PRION PROTEIN; SIRTUIN 1; TETRASPANIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; CREUTZFELDT JAKOB DISEASE; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; HOMODIMERIZATION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

Α-CLEAVAGE; Β-AMYLOID; ADAM10; ALZHEIMER'S DISEASE; NEURODEGENERATION; NEUROTOXIC OLIGOMERS; PRION DISEASE; PRION PROTEIN; SHEDDING;

ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; CELL LINE; HUMANS; MEMBRANE PROTEINS; PRION DISEASES; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; PRPC PROTEINS; PRPSC PROTEINS; SIGNAL TRANSDUCTION;

EID: 84883460724     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12196     Document Type: Review

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