Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome

Neuron

Volumn 87, Issue 2, 2015, Pages 382-398

  Pasciuto, Emanuela ^a,b   Ahmed, Tariq ^a   Wahle, Tina ^a,b   Gardoni, Fabrizio ^c   D'Andrea, Laura ^d   Pacini, Laura ^d   Jacquemont, Sébastien ^e,f,g   Tassone, Flora ^h,i   Balschun, Detlef ^a   Dotti, Carlos G ^a,b,j   Callaerts Vegh, Zsuzsanna ^a   D'Hooge, Rudi ^a   Müller, Ulrike C ^k   Di Luca, Monica ^c   De Strooper, Bart ^a,b,l   Bagni, Claudia ^a,b,d  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^f UNIVERSITÉ DE MONTRÉAL   (Canada)

^g UNIVERSITY OF MONTREAL   (Canada)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^k UNIVERSITY OF HEIDELBERG   (Germany)

^l UNIVERSITY COLLEGE LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADAM10 ENDOPEPTIDASE; AMYLOID PRECURSOR PROTEIN; FRAGILE X MENTAL RETARDATION PROTEIN; MESSENGER RNA; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 5; MITOGEN ACTIVATED PROTEIN KINASE; ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; MEMBRANE PROTEIN; SECRETASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FRAGILE X SYNDROME; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LONG TERM DEPRESSION; MALE; MEMORY; MOLECULAR PATHOLOGY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SYNAPTOGENESIS; TRANSLATION REGULATION; ADOLESCENT; ADULT; AGE; ANIMAL; BRAIN CORTEX; C57BL MOUSE; CELL CULTURE; CHILD; CYTOLOGY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; NEWBORN; PATHOLOGY; SYNAPSE; TIME; TRANSGENIC MOUSE; ULTRASTRUCTURE; YOUNG ADULT;

ADAM PROTEINS; ADOLESCENT; ADULT; AGE FACTORS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; CEREBRAL CORTEX; CHILD; FEMALE; FRAGILE X SYNDROME; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; SYNAPSES; TIME FACTORS; YOUNG ADULT;

EID: 84937432830     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2015.06.032     Document Type: Article

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