Membrane-anchored metalloprotease MDC9 has an α-secretase activity responsible for processing the amyloid precursor protein

Biochemical Journal

Volumn 343, Issue 2, 1999, Pages 371-375

  Koike, Hisashi ^a   Tomioka, Shigeo ^a   Sorimachi, Hiroyuki ^a   Saido, Takaomi C ^b   Maruyama, Kei ^c   Okuyama, Akira ^d   Fujisawa Sehara, Atsuko ^c   Ohno, Shigeo ^e   Suzuki, Koichi ^a   Ishiura, Shoichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^d TAIHO PHARMACEUTICAL CO LTD   (Japan)

^e YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; Hydroxamate

Indexed keywords

ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; MEMBRANE ENZYME; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; MUTANT PROTEIN; PHORBOL ESTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ADAM PROTEINS; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; COS CELLS; CULTURE MEDIA, CONDITIONED; DISINTEGRINS; ENDOPEPTIDASES; ENZYME ACTIVATION; GENE EXPRESSION; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MICE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUSCLE PROTEINS; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE DELETION; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION;

ANIMALIA; SERPENTES;

EID: 0033569653     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3430371     Document Type: Article

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