ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein

Journal of Biological Chemistry

Volumn 286, Issue 47, 2011, Pages 40443-40451

  Moss, Marcia L ^a   Powell, Gary ^b   Miller, Miles A ^c   Edwards, Lori ^b   Qi, Bin ^d   Sang, Qing Xiang Amy ^d   De Strooper, Bart ^e   Tesseur, Ina ^e   Lichtenthaler, Stefan F ^f   Taverna, Mara ^f   Zhong, Julia Li ^g   Dingwall, Colin ^h   Ferdous, Taheera ^h   Schlomann, Uwe ^h   Zhou, Pei ⁱ   Griffith, Linda G ^c   Lauffenburger, Douglas A ^c   Petrovich, Robert ^b   Bartsch, Jörg W ^h,j  

^a BioZyme Inc   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d FLORIDA STATE UNIVERSITY   (United States)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^g CHONGQING UNIVERSITY   (China)

^h KING'S COLLEGE LONDON   (United Kingdom)

ⁱ DUKE UNIVERSITY MEDICAL CENTER   (United States)

^j UNIVERSITY HOSPITAL MARBURG   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY ASSAYS; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; BREAST TUMOR CELLS; EPIDERMAL GROWTH FACTORS; FLUORESCENT PEPTIDES; HIGH SPECIFICITY; INHIBITION CONSTANTS; MATRIX ANALYSIS; MEMBRANE ACTIVITY; MEMBRANE-BOUND; METALLOPEPTIDASES; METALLOPROTEINASES; NEUROBLASTOMA CELLS; PROTEOLYTIC ACTIVITIES; PROTEOMIC APPROACHES; SECRETASES;

AMINO ACIDS; CELL MEMBRANES; CYTOLOGY; ENZYME ACTIVITY; ESCHERICHIA COLI; GLYCOPROTEINS; PEPTIDES; SUBSTRATES;

CATALYST ACTIVITY;

A DISINTEGRIN AND METALLOPROTEINASE PROTEIN 9; ADAM10 ENDOPEPTIDASE; ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN ALPHA; AMYLOID PRECURSOR PROTEIN BETA; CD40 LIGAND; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLYCOPROTEIN; METALLOPROTEINASE; OSTEOACTIVIN; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

ARTICLE; BREAST TUMOR; CELL MEMBRANE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SUBSTRATE; NERVE CELL CULTURE; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; TUMOR CELL LINE;

ADAM PROTEINS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; BIOCATALYSIS; CELL LINE, TUMOR; CELL MEMBRANE; HUMANS; MEMBRANE PROTEINS; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; PROTEIN ARRAY ANALYSIS; PROTEIN STRUCTURE, TERTIARY;

ESCHERICHIA COLI;

EID: 81755171473     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.280495     Document Type: Article

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