Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/γ-secretase activity

Biochemical Journal

Volumn 420, Issue 3, 2009, Pages 391-402

  Riedle, Svenja ^a   Kiefel, Helena ^a   Gast, Daniela ^a   Bondong, Sandra ^a   Wolterink, Silke ^a   Gutwein, Paul ^b   Altevogt, Peter ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

A disintegrin and metalloprotease 10 (ADAM10); L1 cell adhesion molecule (L1 CAM); Nuclear translocation; Presenilin (PS) secretase activity; Raft; Signalling

Indexed keywords

A DISINTEGRIN AND METALLOPROTEASE 10 (ADAM10); L1 CELL-ADHESION MOLECULE (L1-CAM); NUCLEAR TRANSLOCATION; RAFT; SIGNALLING;

ADHESION; ASSOCIATIVE STORAGE; CAMS; CELL CULTURE; CELL MEMBRANES; ENZYME ACTIVITY; MOLECULES;

TUMORS;

ADAM PROTEIN; ADAM10 PROTEIN; GAMMA SECRETASE; NERVE CELL ADHESION MOLECULE L1; PRESENILIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL NUCLEUS; CELL STRAIN HEK293; CONTROLLED STUDY; FEMALE; FLUORESCENCE ANALYSIS; GENETIC REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIPID RAFT; OVARY CARCINOMA; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BINDING SITES; CELL LINE; CELL LINE, TUMOR; CELL NUCLEUS; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; FLOW CYTOMETRY; HUMANS; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; NEURAL CELL ADHESION MOLECULE L1; OVARIAN NEOPLASMS; PRESENILINS; RECEPTORS, RETINOIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFECTION;

MUS MUSCULUS;

EID: 66949155975     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081625     Document Type: Article

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