Alpha-secretase cleavage of the amyloid precursor protein: Proteolysis regulated by signaling pathways and protein trafficking

Current Alzheimer Research

Volumn 9, Issue 2, 2012, Pages 165-177

  Lichtenthaler, Stefan F ^a,b  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Alzheimer's disease; Ectodomain shedding; Metalloprotease; Neurodegeneration; Protein trafficking; Regulated intramembrane proteolysis; Secretases; Signaling pathways

Indexed keywords

ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; ADAM17 PROTEIN; ADAM9 PROTEIN; ADENYLATE CYCLASE; AF 267B; ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CEVIMELINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIACYLGLYCEROL; EHT 0202; ETAZOLATE; G PROTEIN COUPLED RECEPTOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PROTEIN KINASE C; SIRTUIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; CELL MIGRATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; LEARNING; MEMORY; NONHUMAN; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN TRAFFICKING; PROTEIN TRANSPORT; REVIEW; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; HUMANS; MEMBRANE PROTEINS; PROTEIN TRANSPORT; PROTEOLYSIS; SIGNAL TRANSDUCTION;

EID: 84857775196     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/156720512799361655     Document Type: Review

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