Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 50, 2007, Pages 19796-19801

  Chen, Ci Di ^a   Podvin, Sonia ^a   Gillespie, Earl ^a   Leeman, Susan E ^a   Abraham, Carmela R ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloid precursor protein; Antiaging protein; Insulin signaling; Metalloproteinase; Sheddase

Indexed keywords

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; ADAM PROTEIN; ADAM10 PROTEIN; AMYLOID PRECURSOR PROTEIN; APROTININ; BOVINE SERUM ALBUMIN; EDETIC ACID; EGTAZIC ACID; INSULIN; KLOTHO PROTEIN; LEUPEPTIN; MEMBRANE PROTEIN; MESSENGER RNA; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; PEPSTATIN; PROTEINASE INHIBITOR; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TUBULIN; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HORMONE ACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEINASE INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADAM PROTEINS; ANIMALS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; GLUCURONIDASE; INSULIN; RATS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASES;

RATTUS;

EID: 38049144010     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0709805104     Document Type: Article

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