Human NOTCH2 is resistant to ligand-independent activation by metalloprotease adam17

Journal of Biological Chemistry

Volumn 290, Issue 23, 2015, Pages 14705-14716

  Habets, Roger A J ^a   Groot, Arjan J ^a   Yahyanejad, Sanaz ^a   Tiyanont, Kittichoat ^b   Blacklow, Stephen C ^b,c   Vooijs, Marc ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CHEMICAL ACTIVATION; LIGANDS; PROTEOLYSIS; T-CELLS;

CELL SURFACE RECEPTORS; FUNCTIONAL ASSAYS; INTRAMEMBRANE PROTEOLYSIS; LIGAND-INDEPENDENT ACTIVATION; LIGAND-INDEPENDENT SIGNALING; METALLO-PROTEASE; MOLECULAR MECHANISM; REGULATORY REGIONS;

BIOACTIVITY;

GAMMA SECRETASE; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; ADAM PROTEIN; CALCIUM; NOTCH2 PROTEIN, HUMAN; NOTCH2 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIGAND BINDING; LIGAND INDEPENDANT ACTIVATION; MISSENSE MUTATION; MOLECULAR MECHANICS; MOUSE; NEGATIVE REGULATORY REGION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; LEUKEMIA; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN UNFOLDING;

MAMMALIA; MURINAE;

ADAM PROTEINS; AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CELL LINE; HUMANS; LEUKEMIA; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN UNFOLDING; RECEPTOR, NOTCH1; RECEPTOR, NOTCH2;

EID: 84930638722     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.643676     Document Type: Article

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